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The Skin Microbiome in Atopic Dermatitis—a Potential Treatment Target?

  • Atopic Dermatitis (C Vestergaard, Section Editor)
  • Published:
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Abstract

Purpose of Review

Staphylococcus aureus (S. aureus) frequently colonize the skin of patients with atopic dermatitis (AD). The abundance of S. aureus increases during flares, accompanied by a reduction in bacterial diversity. This flare-associated imbalance in the cutaneous microflora (dysbiosis) correlates with disease severity. However, the causality of this association has not yet been fully established, and this review aims to further explore the relation between the skin microbiome and AD along with the clinical implications hereof.

Recent Findings

Recently, it has been shown that the skin microbiome in clinically unaffected skin of AD patients differs from that of healthy individuals. In addition, mutations in the gene encoding the structural protein filaggrin (FLG) have been shown to influence the skin microbiome.

Summary

Skin barrier impairments, which characterize the AD phenotype, influence the skin microbiome and increase the susceptibility to colonization with S. aureus. In turn, S. aureus can promote skin inflammation by a broad spectrum of virulence factors. Modulation of the skin microbiome by transferring beneficial skin commensals to the skin of AD patients may represent a promising strategy for the future management of AD.

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Authors and Affiliations

  1. Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark

    Caroline Meyer Olesen, Maja-Lisa Clausen & Tove Agner

  2. Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark

    Paal Skytt Andersen

  3. Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark

    Paal Skytt Andersen

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  1. Caroline Meyer Olesen
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  4. Tove Agner
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Correspondence to Caroline Meyer Olesen.

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Dr. Agner reports other personal fees outside of the submitted work. Caroline Meyer Olesen, Maja-Lisa Clausen, and Paal Skytt Andersen declare that they have no conflict of interest.

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This article is part of the Topical Collection on Atopic Dermatitis

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Olesen, C.M., Clausen, ML., Andersen, P.S. et al. The Skin Microbiome in Atopic Dermatitis—a Potential Treatment Target?. Curr Derm Rep 7, 199–208 (2018). https://doi.org/10.1007/s13671-018-0245-6

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