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Management of Ovarian Endometrioma in Asymptomatic Reproductive Age Women

  • Reproductive Endocrinology and Infertility (REI) (R Anchan, Section Editor)
  • Published:
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Abstract

Purpose of Review

In asymptomatic women of reproductive age, the presence of an ovarian endometrioma raises a significant management dilemma.

Recent Findings

Surgical management may afford more definitive treatment as well as an opportunity to treat concurrent extra-ovarian endometriotic disease. However, the associated impact on ovarian reserve with ovarian surgery may be an example of the cure being worse than the disease. Several conservative treatments have been studied, all with varying clinical benefits. Expectant management, while a conservative option, may complicate access to growing ovarian follicles and raise risk of surgical site infection during assisted reproductive treatment. Furthermore, a growing body of data suggests that prolonged exposure to the inflammatory endometrioma contributes to ovarian follicular burnout and cortical scarring.

Summary

For patients with a diagnosis of endometrioma who are actively trying to conceive, careful patient counseling and shared decision making represent the best way to decide on a management strategy in order to maximize patient-centered outcomes and reproductive potential.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med. 2020;382(13):1244–56.

    Article  CAS  PubMed  Google Scholar 

  2. Kitajima M, Dolmans M-M, Donnez O, Masuzaki H, Soares M, Donnez J. Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas. Fertil Steril. 2014;101(4):1031–7.

    Article  PubMed  Google Scholar 

  3. Exacoustos C, De Felice G, Pizzo A, Morosetti G, Lazzeri L, Centini G, et al. Isolated ovarian endometrioma: a history between myth and reality. J Minim Invasive Gynecol. 2018;25(5):884–91.

    Article  PubMed  Google Scholar 

  4. Redwine DB. Ovarian endometriosis: a marker for more extensive pelvic and intestinal disease. Fertil Steril. 1999;72(2):310–5.

    Article  CAS  PubMed  Google Scholar 

  5. Chapron C, Pietin-Vialle C, Borghese B, Davy C, Foulot H, Chopin N. Associated ovarian endometrioma is a marker for greater severity of deeply infiltrating endometriosis. Fertil Steril. 2009;92(2):453–7.

    Article  PubMed  Google Scholar 

  6. Somigliana E, Infantino M, Candiani M, Vignali M, Chiodini A, Busacca M, et al. Association rate between deep peritoneal endometriosis and other forms of the disease: pathogenetic implications. Hum Reprod Oxf Engl. 2004;19(1):168–71.

    Article  Google Scholar 

  7. • Lee N, Min S, Won S, Cho YJ, Kim M, Kim MK, et al. The recurrence rate of ovarian endometrioma in women aged 40–49years and impact of hormonal treatment after conservative surgery. Sci Rep. 2020;10(1):16461. This study found that ovarian endometrioma recurred in 34 (8.3%) of women and the median time to recurrence was 22.4 ± 18.2 months. The cumulative recurrences rate at 12, 24, 36, and 60 months were 3.7%, 6.7%, 11.1%, and 16.7%.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Gordts S, Puttemans P, Gordts S, Brosens I. Ovarian endometrioma in the adolescent: a plea for early-stage diagnosis and full surgical treatment. Gynecol Surg. 2015;12(1):21–30.

    Article  PubMed  PubMed Central  Google Scholar 

  9. ASRM. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997;67(5):817–21.

    Article  Google Scholar 

  10. Bulun SE. Endometriosis. N Engl J Med. 2009;360(3):268–79.

    Article  CAS  PubMed  Google Scholar 

  11. Pateman K, Moro F, Mavrelos D, Foo X, Hoo W-L, Jurkovic D. Natural history of ovarian endometrioma in pregnancy. BMC Womens Health. 2014;14:128.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Fernando S, Breheny S, Jaques AM, Halliday JL, Baker G, Healy D. Preterm birth, ovarian endometriomata, and assisted reproduction technologies. Fertil Steril. 2009;91(2):325–30.

    Article  PubMed  Google Scholar 

  13. Seyhan A, Urman B, Turkgeldi E, Ata B. Do endometriomas grow during ovarian stimulation for assisted reproduction? A three-dimensional volume analysis before and after ovarian stimulation. Reprod Biomed Online. 2018;36(2):239–44.

    Article  PubMed  Google Scholar 

  14. Collins BG, Ankola A, Gola S, McGillen KL. Transvaginal US of endometriosis looking beyond the endometrioma with a dedicated protocol. Radiogr Rev Publ Radiol Soc N Am Inc. 2019;39(5):1549–68.

    Google Scholar 

  15. Cranney R, Condous G, Reid S. An update on the diagnosis, surgical management, and fertility outcomes for women with endometrioma. Acta Obstet Gynecol Scand. 2017;96(6):633–43.

    Article  PubMed  Google Scholar 

  16. Nisenblat V, Bossuyt PMM, Farquhar C, Johnson N, Hull ML. Imaging modalities for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016;2:CD009591.

  17. Vercellini P, Bocciolone L, Vendola N, Colombo A, Rognoni MT, Fedele L. Peritoneal endometriosis. Morphologic appearance in women with chronic pelvic pain. J Reprod Med. 1991;36(7):533–6.

    CAS  PubMed  Google Scholar 

  18. Nnoaham KE, Hummelshoj L, Kennedy SH, Jenkinson C, Zondervan KT, World Endometriosis Research Foundation Women’s Health Symptom Survey Consortium. Developing symptom-based predictive models of endometriosis as a clinical screening tool: results from a multicenter study. Fertil Steril. 2012;98(3):692–701.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Hudelist G, Ballard K, English J, Wright J, Banerjee S, Mastoroudes H, et al. Transvaginal sonography vs clinical examination in the preoperative diagnosis of deep infiltrating endometriosis. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 2011;37(4):480–7.

    Article  CAS  Google Scholar 

  20. Lee D, Kim SK, Lee JR, Jee BC. Management of endometriosis-related infertility: considerations and treatment options. Clin Exp Reprod Med. 2020;47(1):1–11.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Daraï E, Detchev R, Hugol D, Quang NT. Serum and cyst fluid levels of interleukin (IL) -6 IL-8 and tumour necrosis factor-alpha in women with endometriomas and benign and malignant cystic ovarian tumours. Hum Reprod Oxf Engl. 2003;18(8):1681–5.

    Article  Google Scholar 

  22. Tseng JF, Ryan IP, Milam TD, Murai JT, Schriock ED, Landers DV, et al. Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosis. J Clin Endocrinol Metab. 1996;81(3):1118–22.

    CAS  PubMed  Google Scholar 

  23. Jayaprakasan K, Becker C, Mittal M. The effect of surgery for endometriomas on fertility: Scientific Impact Paper no 55. BJOG Int J Obstet Gynaecol. 2018;125(6):e19-28.

    Article  Google Scholar 

  24. Matsuzaki S, Schubert B. Oxidative stress status in normal ovarian cortex surrounding ovarian endometriosis. Fertil Steril. 2010;93(7):2431–2.

    Article  PubMed  Google Scholar 

  25. Miravet-Valenciano J, Ruiz-Alonso M, Gómez E, Garcia-Velasco JA. Endometrial receptivity in eutopic endometrium in patients with endometriosis: it is not affected and let me show you why. Fertil Steril. 2017;108(1):28–31.

    Article  PubMed  Google Scholar 

  26. Kasapoglu I, Ata B, Uyaniklar O, Seyhan A, Orhan A, Yildiz Oguz S, et al. Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study. Fertil Steril. 2018;110(1):122–7.

    Article  PubMed  Google Scholar 

  27. •• Ferrero H, Corachán A, Aguilar A, Quiñonero A, Carbajo-García MC, Alamá P, et al. Single-cell RNA sequencing of oocytes from ovarian endometriosis patients reveals a differential transcriptomic profile associated with lower quality. Hum Reprod Oxf Engl. 2019;34(7):1302–12. This study found that oocytes from endometriosis patients, independently of whether they came from the affected ovary, exhibited a differential transcriptomic profile compared to oocytes from healthy egg donors.

    Article  CAS  Google Scholar 

  28. Kobayashi H, Sumimoto K, Kitanaka T, Yamada Y, Sado T, Sakata M, et al. Ovarian endometrioma—Risks factors of ovarian cancer development. Eur J Obstet Gynecol Reprod Biol. 2008;138(2):187–93.

    Article  PubMed  Google Scholar 

  29. Nargund G, Parsons J. Infected endometriotic cysts secondary to oocyte aspiration for in-vitro fertilization. Hum Reprod Oxf Engl. 1995;10(6):1555.

    Article  CAS  Google Scholar 

  30. Padilla SL. Case Report: Ovarian abscess following puncture of an endometrioma during ultrasound-guided oocyte retrieval. Hum Reprod. 1993;8(8):1282–3.

    Article  CAS  PubMed  Google Scholar 

  31. Evangelinakis N, Grammatikakis I, Salamalekis G, Tziortzioti V, Samaras C, Chrelias C, et al. Prevalence of acute hemoperitoneum in patients with endometriotic ovarian cysts: a 7-year retrospective study. Clin Exp Obstet Gynecol. 2009;36(4):254–5.

    CAS  PubMed  Google Scholar 

  32. Busacca M, Riparini J, Somigliana E, Oggioni G, Izzo S, Vignali M, et al. Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas. Am J Obstet Gynecol. 2006;195(2):421–5.

    Article  PubMed  Google Scholar 

  33. Vignali M, Belloni GM, Pietropaolo G, Prun ABD, Barbera V, Angioni S, et al. Effect of Dienogest therapy on the size of the endometrioma. Gynecol Endocrinol. 2020;36(8):723–7.

    Article  CAS  PubMed  Google Scholar 

  34. Harada T, Momoeda M, Taketani Y, Hoshiai H, Terakawa N. Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled double-blind randomized trial. Fertil Steril. 2008;90(5):1583–8.

    Article  PubMed  Google Scholar 

  35. Kavoussi SK, Odenwald KC, As-Sanie S, Lebovic DI. Incidence of ovarian endometrioma among women with peritoneal endometriosis with and without a history of hormonal contraceptive use. Eur J Obstet Gynecol Reprod Biol. 2017;215:220–3.

    Article  CAS  PubMed  Google Scholar 

  36. Donnez J, Nisolle M, Gillerot S, Anaf V, Clerckx-Braun F, Casanas-Roux F. Ovarian endometrial cysts: the role of gonadotropin-releasing hormone agonist and/or drainage. Fertil Steril. 1994;62(1):63–6.

    Article  CAS  PubMed  Google Scholar 

  37. Cohen A, Almog B, Tulandi T. Sclerotherapy in the management of ovarian endometrioma: systematic review and meta-analysis. Fertil Steril. 2017;108(1):117–24.

    Article  PubMed  Google Scholar 

  38. Raffi F, Metwally M, Amer S. The impact of excision of ovarian endometrioma on ovarian reserve: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2012;97(9):3146–54.

    Article  CAS  PubMed  Google Scholar 

  39. Zhang N-N, Sun T-S, Yang Q. An effective “water injection”-assisted method for excision of ovarian endometrioma by laparoscopy. Fertil Steril. 2019;112(3):608–9.

    Article  PubMed  Google Scholar 

  40. Mircea O, Puscasiu L, Resch B, Lucas J, Collinet P, von Theobald P, et al. Fertility outcomes after ablation using plasma energy versus cystectomy in infertile women with ovarian endometrioma: a multicentric comparative study. J Minim Invasive Gynecol. 2016;23(7):1138–45.

    Article  PubMed  Google Scholar 

  41. Donnez J, Nisolle M, Gillet N, Smets M, Bassil S, Casanas-Roux F. Large ovarian endometriomas. Hum Reprod Oxf Engl. 1996;11(3):641–6.

    Article  CAS  Google Scholar 

  42. Pados G, Tsolakidis D, Assimakopoulos E, Athanatos D, Tarlatzis B. Sonographic changes after laparoscopic cystectomy compared with three-stage management in patients with ovarian endometriomas: a prospective randomized study. Hum Reprod. 2010;25(3):672–7.

    Article  PubMed  Google Scholar 

  43. Tsolakidis D, Pados G, Vavilis D, Athanatos D, Tsalikis T, Giannakou A, et al. The impact on ovarian reserve after laparoscopic ovarian cystectomy versus three-stage management in patients with endometriomas: a prospective randomized study. Fertil Steril. 2010;94(1):71–7.

    Article  CAS  PubMed  Google Scholar 

  44. Vercellini P, De Matteis S, Somigliana E, Buggio L, Frattaruolo MP, Fedele L. Long-term adjuvant therapy for the prevention of postoperative endometrioma recurrence: a systematic review and meta-analysis. Acta Obstet Gynecol Scand. 2013;92(1):8–16.

    Article  PubMed  Google Scholar 

  45. Fedele L, Bianchi S, Zanconato G, Berlanda N, Raffaelli R, Fontana E. Laparoscopic excision of recurrent endometriomas: long-term outcome and comparison with primary surgery. Fertil Steril. 2006;85(3):694–9.

    Article  CAS  PubMed  Google Scholar 

  46. Muneyyirci-Delale O, Anopa J, Charles C, Mathur D, Parris R, Cutler JB, et al. Medical management of recurrent endometrioma with long-term norethindrone acetate. Int J Womens Health. 2012;4:149–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Lall Seal S, Kamilya G, Mukherji J, De A, Ghosh D, Majhi AK. Aromatase inhibitors in recurrent ovarian endometriomas: report of five cases with literature review. Fertil Steril. 2011;95(1):291.e15-18.

    Article  Google Scholar 

  48. Velasco I, Rueda J, Acién P. Aromatase expression in endometriotic tissues and cell cultures of patients with endometriosis. Mol Hum Reprod. 2006;12(6):377–81.

    Article  CAS  PubMed  Google Scholar 

  49. Loverro G, Carriero C, Rossi AC, Putignano G, Nicolardi V, Selvaggi L. A randomized study comparing triptorelin or expectant management following conservative laparoscopic surgery for symptomatic stage III–IV endometriosis. Eur J Obstet Gynecol Reprod Biol. 2008;136(2):194–8.

    Article  CAS  PubMed  Google Scholar 

  50. Jee BC, Lee JY, Suh CS, Kim SH, Choi YM, Moon SY. Impact of GnRH agonist treatment on recurrence of ovarian endometriomas after conservative laparoscopic surgery. Fertil Steril. 2009;91(1):40–5.

    Article  CAS  PubMed  Google Scholar 

  51. Muzii L, Marana R, Caruana P, Catalano GF, Margutti F, Panici PB. Postoperative administration of monophasic combined oral contraceptives after laparoscopic treatment of ovarian endometriomas: a prospective randomized trial. Am J Obstet Gynecol. 2000;183(3):588–92.

    Article  CAS  PubMed  Google Scholar 

  52. Vercellini P, Somigliana E, Daguati R, Vigano P, Meroni F, Crosignani PG. Postoperative oral contraceptive exposure and risk of endometrioma recurrence. Am J Obstet Gynecol. 2008;198(5):504.e1-5.

    Article  Google Scholar 

  53. Seracchioli R, Mabrouk M, Frascà C, Manuzzi L, Montanari G, Keramyda A, et al. Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial. Fertil Steril. 2010;93(1):52–6.

    Article  PubMed  Google Scholar 

  54. Sesti F, Capozzolo T, Pietropolli A, Marziali M, Bollea MR, Piccione E. Recurrence rate of endometrioma after laparoscopic cystectomy: a comparative randomized trial between post-operative hormonal suppression treatment or dietary therapy vs. placebo. Eur J Obstet Gynecol Reprod Biol. 2009;147(1):72–7.

    Article  CAS  PubMed  Google Scholar 

  55. Koga K, Osuga Y, Takemura Y, Takamura M, Taketani Y. Recurrence of endometrioma after laparoscopic excision and its prevention by medical management. Front Biosci Elite Ed. 2013;5:676–83.

    Article  PubMed  Google Scholar 

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Correspondence to Pietro Bortoletto.

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Bortoletto, P., Pollie, M. Management of Ovarian Endometrioma in Asymptomatic Reproductive Age Women. Curr Obstet Gynecol Rep 10, 53–60 (2021). https://doi.org/10.1007/s13669-021-00311-6

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