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Algerian Sonchus oleraceus L.: a comparison of different extraction solvent on phytochemical composition, antioxidant properties and anti-cholinesterase activity

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Abstract

Aerial parts of Sonchus oleraceus L. were studied for the antioxidant and anti-cholinesterase activities in different solvent and fractions. Extracts/fractions were analysed for total phenolic, flavonoid and flavonol contents. The chemical constituents of the most active extracts/fractions were analysed using LC–MS/QTOF in the positive ion mode. Ethyl acetate and butanolic fractions exhibited the highest antioxidant activity in DPPH, galvinoxyl and phenanthroline assays due to high contents of phenolics, flavonoids and flavonols. Whereby total alkaloid extract had the highest scavenging activity in ABTS•+ assay. Besides, methanolic extract was noted for the highest inhibitory effect against acetylcholinesterase. Total 24 compounds were identified by LC–MS/QTOF which were phenolic acids, sesquiterpene lactones and phenylpropanoid derivatives. As conclusion, the study revealed that the aerial parts of S. oleraceus are potential sources of natural antioxidant and anti-cholinesterase compounds.

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Acknowledgements

The authors would like to thank Integrative Pharmacogenomics Institute (iPROMISE), UiTM for providing facilities to carry out related research work.

Funding

This study did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Laboratoire Biologie, Eau et Environnement (LBEE), Université 8 Mai 1945, Guelma, P.B. 401, 24000, Guelma, Algeria

    Fatine Aissani

  2. Faculté des Sciences de la Nature et de la Vie et Sciences de la Terre et de l’Univers, Université 8 Mai 1945 Guelma, P.B. 401, 24000, Guelma, Algeria

    Nedjoud Grara, Aissam Bousbia & Hayette Ayed

  3. Biotechnology Research Center (CRBT), Ali Mendjli New Town UV 03, P.B. E73, Constantine, Algeria

    Chawki Bensouici

  4. Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM) Selangor, Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia

    Muhd Hanis Md Idris & Lay Kek Teh

  5. Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Selangor, Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia

    Muhd Hanis Md Idris & Lay Kek Teh

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  1. Fatine Aissani
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Contributions

FA conducted the experimental work, collected the data, and wrote the draft of manuscript. NG, CB, AB and TLK conceived and designed the experiment, and furnished the designated work. HA and MHMI checked the experimental results, analysed the data, and critically reviewed the manuscript. All authors had read and approved the final manuscript.

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Correspondence to Muhd Hanis Md Idris.

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The current work did not involve animals and human. The authors also would like to declare that the present manuscript and data have not been published and are not currently under review for publication elsewhere.

Conflict of interest

Fatine Aissani has no conflict of interest. Nedjoud Grara has no conflict of interest. Chawki Bensouici has no conflict of interest. Aissam Bousbia has no conflict of interest. Hayette Ayed has no conflict of interest. Muhd Hanis Md Idris has no conflict of interest. Lay Kek Teh has no conflict of interest.

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Aissani, F., Grara, N., Bensouici, C. et al. Algerian Sonchus oleraceus L.: a comparison of different extraction solvent on phytochemical composition, antioxidant properties and anti-cholinesterase activity. ADV TRADIT MED (ADTM) 22, 383–394 (2022). https://doi.org/10.1007/s13596-021-00553-y

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