Abstract
Hepatoxicity is a common complication of acetaminophen. This study was to evaluate the effects of Nectaroscordum tripedale extract (NTE) and its bioactive component tetramethylpyrazine (TMP) on acetaminophen-induced liver failure. The presence of TMP in NTE was determined by HPLC. The hepatoprotective effect of NTE and TMP (50, 100 and 200 mg/kg, respectively) was evaluated by the assay of liver function parameters; total bilirubin, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase activities (ALP) and superoxide dismutase (SOD). Results revealed that TMP was 1.24 mg/g in NTE. LD50 of the NTE and TMP was 3800 mg/kg and 2700 mg/kg, respectively. NTE and TMP (100 and 200 mg/kg) decreased the ALT, AST, ALP, and bilirubin but the SOD increased in a dose-dependent manner in acetaminophen-induced liver failure rats. In conclusion, NTE and its fraction TMP may be a protecting liver candidate against acetaminophen-induced hepatotoxicity.
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The authors are grateful for the financial and technical support of the Ilam University of Medical Science.
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The study was approved by the Ilam University of medical sciences (Animal's ethics committee, IR.MEDILAM.REC.1397.85).
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Ali Aidy has no conflict of interest. Elahe Karimi has no conflict of interest. Hori Ghaneialvar has no conflict of interest. Shahram Mohammadpour has no conflict of interest. Naser Abbasi has no conflict of interest.
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Aidy, A., Karimi, E., Ghaneialvar, H. et al. Protective effect of Nectaroscordum tripedale extract and its bioactive component tetramethylpyrazine against acetaminophen-induced hepatotoxicity in rats. ADV TRADIT MED (ADTM) 20, 471–477 (2020). https://doi.org/10.1007/s13596-020-00431-z
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DOI: https://doi.org/10.1007/s13596-020-00431-z