Abstract
Bauhinia variegata Linn. (Caesalpiniaceae), also known as ‘Kanchnar’, is an important medicinal plant mentioned in Ayurveda. In present study, we evaluated the effect of alcoholic extract of leaves of B. variegata in streptozotocin (STZ) induced type 1 diabetes. Diabetes was induced in male Sprague Dawley rats by using STZ (55 mg/kg, i.p). Diabetic animals were orally administered with alcoholic extract (AlcE) of B. variegata at dose of 250, 500 and 1000 mg/kg body weight for 4 weeks. Glipizide (5 mg/kg) was used as standard drug. Biochemical parameters analysis, Oral glucose tolerance test (OGTT) and histopathological studies were carried out at the end. The percent decrease in plasma glucose level was 22.67 %, 29.32 % and 41.78 % respectively for groups treated with AlcE 500 and 1000 mg/kg and glipizide. Body weight was increased after treatment with AlcE at dose of 500 and 1000 mg/kg. In OGTT, AlcE showed improvement in glucose tolerance. AlcE had also significantly lowered the cholesterol, triglyceride, creatinine, BUN and increased the total protein and albumin level at dose of 500 and 1000 mg/kg. Histological analysis showed that AlcE have protective effect on pancreatic cells. Alcoholic extract of Bauhinia variegata showed significant antidiabetic effect in STZ induced type 1 diabetes.
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Acknowledgment
Authors are thankful to Department of Science and Technology, Government of India (IFA 12-LSPA-14), for providing funding to the present research.
Ethical Statement
Experimental protocol was in compliance with the NIH guidelines on handling of experimental animals and was approved by Institutional Animal Ethics Committee.
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Authors declare no conflict of interest.
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Kulkarni, Y.A., Garud, M.S. Effect of Bauhinia variegata Linn. (Caesalpiniaceae) extract in streptozotocin induced type I diabetic rats. Orient Pharm Exp Med 15, 191–198 (2015). https://doi.org/10.1007/s13596-015-0186-6
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DOI: https://doi.org/10.1007/s13596-015-0186-6