Skip to main content

Advertisement

SpringerLink
Log in

Effects of Acanthopanax divaricatus var. albeofructus in mice submitted to protein restriction

  • Research Article
  • Published:
Oriental Pharmacy & Experimental Medicine Aims and scope Submit manuscript

Abstract

The present study was to investigate the effects of water extracts of Acanthopanax divaricatus var. albeofructus stem extract (ADE) on an exacerbated immune function through utilization of a protein-energy malnutrition (PEM) diet. ADE has been used in Korea as a tonic and sedative agents as well as a drug with ginseng like activities. However, there is no pronouncing about the immune system on the PEM feeding mice. The immobility time were significantly decreased in the ADE-administrated group as compared to the control group on the forced swimming test (P < 0.05). The level of aspartate aminotransferase and lactate dehydrogenase in blood was significantly reduced in the ADE-administrated group (P < 0.05). ADE also significantly decreased production of interferon-γ and interleukin (IL)-4 but not IL-2 in splenocytes (P < 0.05). We used a manually antibody microarray to carry out the signaling protein microarray analysis. Unfortunately, we did not find change of protein expression. These results suggest that ADE have the anti-fatigue effect and the immune regulation effect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • Bae EA, Yook CS, Oh OJ, Chang SY, Toshihiro N, Kim DH (2001) Metabolism of Chiisanoside from Acanthopanax divaricatus var. albeofructus by human intestinal bacteria and its relation to some biological activities. Biol Pharm Bull 24:582–585

    Article  PubMed  CAS  Google Scholar 

  • Bessman SP, Carpenter CL (1985) The creatine-creatine phosphate energy shuttle. Annu Rev Biochem 54:831–862

    Article  PubMed  CAS  Google Scholar 

  • Borsini F, Cesana R, Vidi A, Mennini T (1991) Evidence that imipramine activates 5-HT1C receptor function. Eur J Pharmacol 203:359–363

    Article  PubMed  CAS  Google Scholar 

  • Burr JR, Reinhart GA, Swenson RA, Swaim SE, Vaughn DM, Bradley DM (1997) Serum biochemical values in sled dogs before and after competing in long-distance races. J Am Vet Med Assoc 211:175–179

    PubMed  CAS  Google Scholar 

  • Chandra RK (2002) Nutrition and the immune system from birth to old age. Eur J Clin Nutr 56:73–76

    Article  Google Scholar 

  • Connor TJ, Kelly JP, Leonard BE (1997) Forced swim test-induced neurochemical endocrine, and immune changes in the rat. Pharmacol Biochem Behav 58:961–967

    Article  PubMed  CAS  Google Scholar 

  • Connor TJ, Kelly JP, Leonard BE (1998) Forced swim testinduced endocrine and immune changes in the rat: effect of subacute desipramine treatment. Pharmacol Biochem Behav 59:171–177

    Article  PubMed  CAS  Google Scholar 

  • Coombes JS, McNaughton LR (2000) Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise. J Sports Med Phys Fitness 40:240–246

    PubMed  CAS  Google Scholar 

  • Cunningham-Rundles S, McNeely D, Ananworanich JM (2004) Immune response in malnutrition. In: Stiehm ER, Ochs HD, Winkelstein JA (eds) Immunologic disorders in infants and children. Saunders, Philadelphia

    Google Scholar 

  • Cunningham-Rundles S, McNeely DF, Moon A (2005) Mechanisms of nutrient modulation of the immune response. J Allergy Clin Immunol 115:1119–1128

    Article  PubMed  CAS  Google Scholar 

  • Davydov M, Krikorian AD (2000) Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. J Ethnopharmacol 72:345–393

    Article  PubMed  CAS  Google Scholar 

  • Delbende C, Tranchand Bunel D, Tarozzo G, Grino M, Oliver C, Mocaer E, Vaudry H (1994) Effect of chronic treatment with the antidepressant tianeptine on the hypothalamo-pituitary-adrenal axis. Eur J Pharmacol 251:245–251

    Article  PubMed  CAS  Google Scholar 

  • De-Mello MA (1992) Effect of exercise during pregnancy and dam age on maternal blood chemistry and fetal growth. Braz J Med Biol Res 25:537–542

    PubMed  CAS  Google Scholar 

  • Dorchy H (2002) Sports and type I diabetes: personal experience. Rev Méd Brux 23:211–217

    Google Scholar 

  • Fock RA, Vinolo MA, Crisma AR, Nakajima K, Rogero MM, Borelli P (2008) Protein-energy malnutrition modifies the production of interleukin-10 in response to lipopolysaccharide (LPS) in a murine model. J Nutr Sci Vitaminol (Tokyo) 54:371–377

    Article  CAS  Google Scholar 

  • Fujikawa T, Yamaguchi A, Morita I, Takeda H, Nishibe S (1996) Protective effects of Acanthopanax senticosus Harms from Hokkaido and its components on gastric ulcer in restrained cold water stressed rats. Biol Pharm Bull 19:1227–1230

    PubMed  CAS  Google Scholar 

  • Gaffney BT, Hugel HM, Rich PA (2001) Panax ginseng and Eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors. Med Hypotheses 56:567–572

    Article  PubMed  CAS  Google Scholar 

  • Irwin M, Smith TL, Gillin JC (1987) Low natural killer cytotoxicity in major depression. Life Sci 41:2127–2233

    Article  PubMed  CAS  Google Scholar 

  • Keusch GT (2003) The history of nutrition: malnutrition, infection and immunity. J Nutr 133:336–340

    Google Scholar 

  • Kim NH, Kim KY, Kim JA, Kim YH, Kang IC, Kim HM, Jeong HJ (2010) Immune-enhancing effect of Acanthopanax Koreanum and its component, Eleutheroside E on the protein-energy malnourished C57bl/6 mice. Orient Pharm Exp Med 10:191–199

    Article  Google Scholar 

  • Koo HN, Lee JK, Hong SH, Kim HM (2004) Herbkines increases physical stamina in mice. Biol Pharm Bull 27:117–119

    Article  PubMed  CAS  Google Scholar 

  • Kronfol Z, House JD (1989) Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls. Acta Psychiatr Scand 80:142–147

    Article  PubMed  CAS  Google Scholar 

  • McMurray DN (1981) Cellular immune changes in undernourished children. Prog Clin Biol Res 67:305–318

    PubMed  CAS  Google Scholar 

  • Perry LM, Metzger J (1981) Medicinal plants of east and southeast of Asia. MIT, Cambridge, pp 41–42

    Google Scholar 

  • Porsolt RD, Anton G, Blavet N, Jalfre M (1978) Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379–391

    Article  PubMed  CAS  Google Scholar 

  • Prentice AM (1999) The thymus: a barometer of malnutrition. Br J Nutr 81:345–347

    PubMed  CAS  Google Scholar 

  • Renner EL, Dällenbach A (1992) Increased liver enzymes: what should be done? Ther Umsch 49:281–286

    PubMed  CAS  Google Scholar 

  • Rose RJ, Sampson D (1982) Changes in certain metabolic parameters in horses associated with food deprivation and endurance exercise. Res Vet Sci 32:198–202

    PubMed  CAS  Google Scholar 

  • Shu J, Stevenson JR, Zhou X (1993) Modulation of cellular immune responses by cold water swim stress in the rat. Dev Comp Immunol 17:357–371

    Article  PubMed  CAS  Google Scholar 

  • Vasquez-Garibay E, Campollo-Rivas O, Romero-Velarde E (2002) Effect of renutrition on natural and cell-mediated immune response in infants with severe malnutrition. J Pediatr Gastroenterol Nutr 34:296–301

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgement

We thank Kwang Su Soung, a president at SKSOGAPY CO. Ltd., for Acanthopanax divaricatus var. albeofructus stem extract support.

Author information

Authors and Affiliations

  1. Department of Pharmacology, Oriental Medical Science Center, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

    Kyu-Yeob Kim & Hyung-Min Kim

  2. Department of Biological Science, College of Natural Science, Biochip Research Center, Hoseo University, Asan, Chungnam, Republic of Korea

    Chan-Won Park, In-Cheol Kang & Hyun-Ja Jeong

Authors
  1. Kyu-Yeob Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chan-Won Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hyung-Min Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. In-Cheol Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hyun-Ja Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to In-Cheol Kang or Hyun-Ja Jeong.

Additional information

In-Cheol Kang and Hyun-Ja Jeong contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, KY., Park, CW., Kim, HM. et al. Effects of Acanthopanax divaricatus var. albeofructus in mice submitted to protein restriction. Orient Pharm Exp Med 11, 15–23 (2011). https://doi.org/10.1007/s13596-011-0005-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13596-011-0005-7

Keywords

Search

Navigation