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Wnt, notch signaling and exercise: what are their functions?

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Abstract

In the last decade, the study of Wnt and Notch signaling in cell biology has led to significant progress in understanding embryogenesis, bone development, muscle healing, neurogenesis, and tumorigenesis. It has been found that regular physical activity can counteract the decline of skeletal muscle caused by aging, which is linked to osteoporosis, regenerative neurogenesis, hippocampal function, cognitive ability, and the creation of neuromuscular junctions. Despite these discoveries, there is still uncertainty about how cell biology and exercise can impact the Wnt and Notch signaling pathways in the locomotor system. This review aims to summarize the potential influence of exercise on Wnt and Notch signaling.

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Acknowledgements

Research Fund Project of Hebei Provincial Health Commission. Project title: A Study on the Promotion of Health for University Teachers through Exercise Prescription Management in the Context of Body-Medicine Integration. Approval number: 20231552.

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Authors and Affiliations

  1. Ministry of Public Sports, Hebei North University, Zhangjiakou, 075000, Hebei, China

    Yijie Zhao & Guangjun Wang

  2. The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, Hebei, China

    Zhifeng Wei & Duo Li

  3. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

    Mohammadamin Morshedi

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Zhao, Y., Wang, G., Wei, Z. et al. Wnt, notch signaling and exercise: what are their functions?. Human Cell (2024). https://doi.org/10.1007/s13577-024-01036-3

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