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Paraoxonase-2 expression in oral squamous cell carcinoma

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References

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7–30.

    Article  PubMed  Google Scholar 

  2. Liu JC. Head and neck cancer multimodality management, 2nd ed, Editor: Jacques Bernier Jeffrey C. Liu Springer, Switzerland, 2016, 878 pages. Head Neck. 2016. https://doi.org/10.1002/hed.24920.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Parween F, Gupta RD. Insights into the role of paraoxonase 2 in human pathophysiology. J Biosci. 2022;47(1):4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Krüger M, Pabst AM, Al-Nawas B, Horke S, Moergel M. Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis. J Cancer Res Clin Oncol. 2015;141(10):1757–66.

    Article  PubMed  Google Scholar 

  5. Krüger M, Amort J, Wilgenbus P, et al. The anti-apoptotic PON2 protein is Wnt/β-catenin-regulated and correlates with radiotherapy resistance in OSCC patients. Oncotarget. 2016;7(32):51082–95.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Campagna R, Bacchetti T, Salvolini E, et al. Paraoxonase-2 silencing enhances sensitivity of A375 melanoma cells to treatment with cisplatin. Antioxidants (Basel). 2020;9(12):1238.

    Article  CAS  PubMed  Google Scholar 

  7. Sartini D, Campagna R, Lucarini G, et al. Differential immunohistochemical expression of paraoxonase-2 in actinic keratosis and squamous cell carcinoma. Hum Cell. 2021;34(6):1929–31.

    Article  CAS  PubMed  Google Scholar 

  8. Nagarajan A, Dogra SK, Sun L, et al. Paraoxonase 2 facilitates pancreatic cancer growth and metastasis by stimulating GLUT1-mediated glucose transport. Mol Cell. 2017;67(4):685–701.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Author notes

  1. Roberto Campagna and Valentina Pozzi have contributed equally to this work.

Authors and Affiliations

  1. Department of Clinical Sciences, Polytechnic University of Marche, 60020, Ancona, Italy

    Roberto Campagna, Valentina Pozzi, Alessia Salvucci, Lucrezia Togni, Marco Mascitti, Davide Sartini, Eleonora Salvolini, Andrea Santarelli & Monica Emanuelli

  2. Dentistry Clinic, National Institute of Health and Science of Aging, IRCCS INRCA, 60124, Ancona, Italy

    Andrea Santarelli

  3. Department of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy

    Lorenzo Lo Muzio

  4. New York-Marche Structural Biology Center (NY-MaSBiC), Polytechnic University of Marche, 60131, Ancona, Italy

    Monica Emanuelli

Authors
  1. Roberto Campagna
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  2. Valentina Pozzi
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  3. Alessia Salvucci
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  4. Lucrezia Togni
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  5. Marco Mascitti
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  6. Davide Sartini
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  7. Eleonora Salvolini
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  8. Andrea Santarelli
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  9. Lorenzo Lo Muzio
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  10. Monica Emanuelli
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Corresponding author

Correspondence to Davide Sartini.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This retrospective study was performed on formalin-fixed and paraffin-embedded tissue specimens, previously collected for diagnostic purposes. According to the Ethics Committee of the Marche region ethical approval for retrospective studies is not required.

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All participants gave their informed consent.

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Campagna, R., Pozzi, V., Salvucci, A. et al. Paraoxonase-2 expression in oral squamous cell carcinoma. Human Cell 36, 1211–1213 (2023). https://doi.org/10.1007/s13577-023-00875-w

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  • DOI: https://doi.org/10.1007/s13577-023-00875-w

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