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RETRACTED ARTICLE: Long non-coding RNA MIAT promotes the growth of melanoma via targeting miR-150

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This article was retracted on 28 June 2022

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Abstract

Melanoma is a common skin cancer and it can lead to high mortality probably by early invasion and metastasis. LncRNA MIAT is involved in tumor proliferation, invasion and epithelial-to-mesenchymal transition (EMT). However, the roles of MIAT in melanoma still require further investigation. Thus, the aim of the study is to investigate the roles of MIAT in melanoma, especially the effects of MIAT on EMT of melanoma cancer cells. The results showed that the expression of MIAT was significantly upregulated in melanoma tissue and cells compared with the normal skin and normal melanocytes; moreover, miR-150 was confirmed as a target of MIAT. Furthermore, knockdown of MIAT inhibited cell proliferation and invasion in melanoma cancer cells and transfection of miR-150 inhibitors partial abrogated the anti-tumor effects of MIAT siRNA. In addition, MIAT siRNA also inhibited the EMT of melanoma cells, while miR-150 inhibitors can reverse the effects of MIAT siRNA. Finally, knockdown of MIAT also inhibited the carcinogenic effects of melanoma in vivo by targeting miR-150. In conclusion, we reported that MIAT promotes the proliferation, invasion and EMT of melanoma cells via targeting miR-150, which suggested that MIAT might be a therapeutic target for the treatment of melanoma.

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Author notes

  1. Lifei Zhu and Yexiao Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Dermatology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China

    Lifei Zhu, Chaoying Yang, Yanchang Li, Zhixin Zheng & Liangcai Wu

  2. Department of Dermatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Yexiao Wang & Hui Zhou

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  1. Lifei Zhu
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  2. Yexiao Wang
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  3. Chaoying Yang
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  4. Yanchang Li
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  5. Zhixin Zheng
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Correspondence to Liangcai Wu or Hui Zhou.

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All the authors declare that they have no competing financial interests.

Ethical approval

The study was performed in accordance with the Declaration of Helsinki and ethical committee of the Sixth Affiliated Hospital of Sun Yat-sen University (approval number no: 20170209). All animal experiments were approved by ethical committee of the Sixth Affiliated Hospital of Sun Yat-sen University.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s13577-022-00742-0

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Zhu, L., Wang, Y., Yang, C. et al. RETRACTED ARTICLE: Long non-coding RNA MIAT promotes the growth of melanoma via targeting miR-150. Human Cell 33, 819–829 (2020). https://doi.org/10.1007/s13577-020-00340-y

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  • DOI: https://doi.org/10.1007/s13577-020-00340-y

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