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Re-irradiation of central nervous system tumors

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Journal of Radiation Oncology

Abstract

Recurrence or progression of disease is a common occurrence for some CNS tumors and is an important therapeutic dilemma. Disease progression can lead to worsening of neurological symptoms, including potential neurologic death. Therefore, local control of brain tumors in previously irradiated patients is of critical importance clinically. This poses a therapeutic challenge for clinicians when considering re-irradiation in terms of efficacy and potential toxicity. Multiple re-irradiation strategies for the management of recurrent or progressive disease have been evaluated. This report reviews data for efficacy and safety of re-irradiation in managing recurrent or progressive CNS (brain and spine) tumors.

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Conflict of interest

Muhammad B. Tariq has no relevant conflicts of interest to declare.

Ehsan H. Balagamwala has no relevant conflicts of interest to declare.

Samuel T. Chao has no relevant conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Radiation Oncology, Brain Tumor and Neuro-oncology Center, Cleveland Clinic, Taussig Cancer Institute, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Muhammad B. Tariq, Ehsan H. Balagamwala & Samuel T. Chao

Authors
  1. Muhammad B. Tariq
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  2. Ehsan H. Balagamwala
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  3. Samuel T. Chao
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Correspondence to Samuel T. Chao.

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Tariq, M.B., Balagamwala, E.H. & Chao, S.T. Re-irradiation of central nervous system tumors. J Radiat Oncol 4, 105–115 (2015). https://doi.org/10.1007/s13566-015-0189-4

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  • DOI: https://doi.org/10.1007/s13566-015-0189-4

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