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Total cholesterol and postprandial triglyceride levels as early markers of GDM in Asian Indian women

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Background/objective

Early detection and prompt treatment of GDM will go a long way in reducing the burden of T2DM. This study was undertaken to evaluate whether abnormal lipid profile including fasting as well as postprandial triglycerides, fasting total cholesterol, LDL cholesterol, and HDL cholesterol at 12 weeks of gestation (first trimester) may be used as simple predictive risk markers for developing GDM at a later stage.

Methods

It was a prospective case-control study carried out in 45 subjects with GDM and selected equal number of age and BMI matched non-GDM subjects. A mixed meal consisting of two plain parathas and 20-g butter was given to all the subjects to evaluate 4-h triglyceride levels. Lipid levels were measured in all subjects at 11–13 weeks of gestation. At 24–28 weeks, all subjects were screened for GDM using a standardized oral glucose tolerance test.

Results

The study found significantly higher levels of fasting cholesterol, LDLc, and PPTg levels in subjects in their first trimester in those with GDM compared to those without GDM. Logistic regression analysis revealed higher odds of GDM with increasing 4-h PPTg levels {OR=1.01(1.001-1.02), p=0.02} and fasting cholesterol [OR=1.02 (1.001-1.03), p=0.001]. The ROC curve generated for the combined model of total cholesterol and PPTg has a higher area under the curve as compared to other parameters.

Conclusion

A combination of elevated fasting cholesterol and PPTg levels at an early stage of gestation can significantly predict future GDM.

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Funding

This work was supported by University College of Medical Sciences IMRG grant-2019.

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Authors and Affiliations

  1. Department of Endocrinology, University College of Medical Sciences & GTB Hospital, University of Delhi, Dilshad Garden, Delhi, New Delhi, 110095, India

    S. V. Madhu, B. K. Mishra & M. Aslam

  2. Department of Medicine, University College of Medical Sciences & GTB Hospital, University of Delhi, Dilshad Garden, Delhi, New Delhi, 110095, India

    S. Bhardwaj

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  1. S. V. Madhu
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  2. S. Bhardwaj
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  4. M. Aslam
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Correspondence to B. K. Mishra.

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Ethical clearance was obtained from postgraduate review committee of University College of Medical Sciences and written consent was obtained from all the study participants.

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Madhu, S.V., Bhardwaj, S., Mishra, B.K. et al. Total cholesterol and postprandial triglyceride levels as early markers of GDM in Asian Indian women. Int J Diabetes Dev Ctries 42, 630–635 (2022). https://doi.org/10.1007/s13410-022-01046-7

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  • DOI: https://doi.org/10.1007/s13410-022-01046-7

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