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Correlation analysis of triglycerides to high-density lipoprotein-cholesterol ratio associated with gestational diabetes mellitus

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Background

Gestational diabetes mellitus (GDM) initiates when a woman’s pancreas could not act appropriately to bypass the diabetogenic condition during pregnancy. It is increasing across the world, including Bangladesh. Triglycerides (TG) and high-density lipoprotein-cholesterol (HDLC) are strongly connected with insulin resistance in pregnant women.

Objectives

Observation of the role of lipid profiles and TG/HDL cholesterol ratio associated with fasting glucose in GDM subjects.

Methods

In this experiment, a total of 232 individual subjects consisting of 132 GDM-positive and 100 GDM-negative pregnant women were examined and observed from 24 to 28 weeks of their pregnancy period. For this study, we had collected blood samples from selected women before and after breakfast and analyzed blood glucose level, triglyceride cholesterol level, HDL, low-density lipoprotein (LDL), and TG/HDL ratio.

Results

TG and LDL-cholesterol were significantly higher (p < 0.001) in GDM individuals (220.95 ± 67.4 and 149.54 ± 32.4, respectively) than those of the non-GDM (160.98 ± 59.67 and 129.18 ± 34.18, respectively). On the contrary, HDL-cholesterol level was comparatively lower in GDM-positive women than non-GDM subjects. In this case, the optimum cut-off point was 3.8 for the TG/HDL-C ratio with 62% sensitivity and 78% specificity by oral glucose tolerance test (OGTT).

Conclusion

Significantly (p < 0.001) higher TG/HDL ratio was found in GDM women compared with those in non‐GDM. TG/HDL ratios are independently associated with the risks of GDM, which might be a good marker in predicting GDM risk.

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The dataset will be available upon request unless there are legal or ethical reasons for not doing so.

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Acknowledgements

The authors wish to thank the Department of Biochemistry and Cell Biology, BUHS and the Department of Genetic Engineering and Biotechnology, University of Rajshahi, Bangladesh, for providing financial support and other facilities during the whole research work. We would like to thank Md. Mominul Islam, Department of Physiology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh, for his critical review of this article.

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Authors and Affiliations

  1. Department of Biochemistry and Cell Biology, Bangladesh University of Health Sciences (BUHS), Mirpur, Dhaka, 1216, Bangladesh

    Md. Mim Obaidullah & Israt Ara Hossain

  2. Molecular Genetics Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6205, Bangladesh

    Shirmin Islam, Md. Rayhan Chowdhury & Mohammad Nurul Matin

  3. Department of Biochemistry, Primeasia University, Banani, Dhaka, 1213, Bangladesh

    Lubatul Arbia

Authors
  1. Md. Mim Obaidullah
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  4. Lubatul Arbia
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  6. Mohammad Nurul Matin
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Contributions

MMO, IAH, MNM; Conceptualization. MMO, IAH, MNM; Methodology. IAH, MNM; Investigation. MMO, SI, MRC; Writing-original draft preparation. MMO, MRC, SI, LA, MNM; Writing-review and editing. MMO, MRC, SI; Manuscript revision. IAH, MNM; Supervision.

Corresponding author

Correspondence to Mohammad Nurul Matin.

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Ethics approval

Ethical issue of this study was approved by the ethical review board of the Institute of Biological Sciences (IBSc) of the University of Rajshahi, Rajshahi-6205, Bangladesh, under the certificate number 255(14)/320/IAMEBBC/IBSc. Informed written consent was taken from all patients enrolled in this study.

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The written consent from the participants was taken, describing that the survey report will be published in the journal.

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The authors declare no competing interests.

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Obaidullah, M.M., Islam, S., Chowdhury, M.R. et al. Correlation analysis of triglycerides to high-density lipoprotein-cholesterol ratio associated with gestational diabetes mellitus. Int J Diabetes Dev Ctries 42, 636–641 (2022). https://doi.org/10.1007/s13410-021-01016-5

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  • DOI: https://doi.org/10.1007/s13410-021-01016-5

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