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Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin

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Abstract

Objective

Studies are limited on the association between serum transthyretin (TTR), a negative acute phase reactant, and triglyceride (TG).

Research design and methods

TG, TTR, and insulin resistance-related cardiometabolic variables were measured in 159 fasting and 185 nonfasting community-dwelling elderly women aged 50–96 years. Pearson correlation analysis and then stepwise multiple regression analyses were performed to further identify the most significant variables contributing to the variation of fasting and nonfasting TG.

Results

Multiple regression analysis for fasting TG as a dependent variable revealed that TTR (standardized β: 0.299) and HDL cholesterol (standardized β: -0.545) emerged as determinants of TG independently of percentage of body fat, homeostasis model assessment insulin resistance, serum leptin and adiponectin, and plasminogen activator inhibitor-1 (PAI-1) (R2 = 0.36). For nonfasting TG, HDL cholesterol (standardized β: − 0.461), TTR (standardized β: 0.231), nonfasting insulin, a marker of insulin resistance, (standardized β: 0.202), and PAI-1 (standardized β: 0.187) emerged as determinants independently of percentage of body fat, nonfasting glucose, serum leptin and adiponectin, and high-sensitivity C-reactive protein (R2 = 0.45).

Conclusions

Fasting and nonfasting TG showed positive association with TTR in community-dwelling elderly non-obese women independently of insulin resistance, HDL cholesterol, and adiponectin. These findings may provide a clue as to a physiological function of circulating TTR in human: an influence factor of TG-rich lipoproteins in the circulation.

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Acknowledgements

We are indebted to all the participants for their dedicated and conscientious collaboration.

Author information

Authors and Affiliations

  1. Research Institute for Nutrition Sciences, Mukogawa Women’s University, 6-46, Ikebiraki-cho, Nishinomiya, Hyogo, 663-8558, Japan

    Satomi Minato-Inokawa, Ayaka Tsuboi, Mika Takeuchi, Kaori Kitaoka, Megumu Yano, Miki Kurata, Tsutomu Kazumi & Keisuke Fukuo

  2. Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Ehime, Japan

    Satomi Minato-Inokawa

  3. Department of Nutrition, Osaka City Juso Hospital, Osaka, Japan

    Ayaka Tsuboi

  4. Department of Food Sciences and Nutrition, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan

    Miki Kurata & Keisuke Fukuo

  5. Department of Medicine, Kohnan Kakogawa Hospital, Kakogawa, Hyogo, Japan

    Tsutomu Kazumi

Authors
  1. Satomi Minato-Inokawa
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  2. Ayaka Tsuboi
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  3. Mika Takeuchi
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  4. Kaori Kitaoka
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  5. Megumu Yano
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  6. Miki Kurata
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  7. Tsutomu Kazumi
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  8. Keisuke Fukuo
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Corresponding author

Correspondence to Tsutomu Kazumi.

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None of the authors have any potential conflicts of interest to declare associated with this research.

Ethical approval

This study was approved by the Ethics Committees of Mukogawa Women’s University (No. 11–7, approval date: not applicable). All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and/or with the Helsinki Declaration of 1964 and later versions.

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Minato-Inokawa, S., Tsuboi, A., Takeuchi, M. et al. Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin. Diabetol Int 12, 405–411 (2021). https://doi.org/10.1007/s13340-021-00496-4

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  • DOI: https://doi.org/10.1007/s13340-021-00496-4

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