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Transcriptomic characterization of differential gene expression in oral squamous cell carcinoma: a meta-analysis of publicly available microarray data sets

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Tumor Biology

Abstract

Oral squamous cell carcinoma (OSCC) is a highly prevalent cancer worldwide, and OSCC often goes undiagnosed until advanced disease is present, which contributes to a low survival rate for OSCC patients. The identification of biomarkers for the early detection OSCC and novel therapeutic targets for OSCC treatment is an important research objective. We performed bioinformatics analyses of the gene expression profile of OSCC using microarray data to identify genes that contribute to the development of OSCC. We also predicted the transcription factors involved in the regulation of differential gene expression in OSCC. Our results showed that PI3K, EGFR, STAT1, and CPBP are important contributors to the changes in cellular physiology that occur during the development of OSCC. Therefore, these genes represent potential diagnostic biomarkers and therapeutic targets for OSCC.

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Acknowledgments

Funding for this study was provided by Zhongshan Hospital, Fudan University.

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Authors and Affiliations

  1. Department of Stomatology, Zhongshan Hospital, Fudan University, 111 Yixueyuan Road, Shanghai, 200032, China

    Yang Sun, Zhijian Sang, Qian Jiang, Xiaojun Ding & Youcheng Yu

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  1. Yang Sun
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  2. Zhijian Sang
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Correspondence to Xiaojun Ding.

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Our study was approved by the Hospital Ethics Committee of Zhongshan Hospital and Fudan University (Shanghai, China), which determined that patient consent was not required for our analysis of publicly available data sets.

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None.

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Yang Sun and Zhijian Sang contributed equally to this work.

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Sun, Y., Sang, Z., Jiang, Q. et al. Transcriptomic characterization of differential gene expression in oral squamous cell carcinoma: a meta-analysis of publicly available microarray data sets. Tumor Biol. 37, 15913–15924 (2016). https://doi.org/10.1007/s13277-016-5439-6

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