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ABCE1 plays an essential role in lung cancer progression and metastasis

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Tumor Biology

Abstract

ATP-binding cassette E1 (ABCE1) is a member of the ATP-binding cassette transporters and regulates a broad range of biological functions including viral infection, cell proliferation, and anti-apoptosis. We have previously shown that ABCE1 is a prognostic indicator for lung cancer, although the underlying mechanisms remain unclear. To investigate whether the ABCE1 gene contributes to the malignancy of lung tumors, we introduced ABCE1 into LTEP-a-2 lung adenocarcinoma cells. Ectopic ABCE1 expression promoted clonogenicity and anchorage-independent growth of LTEP-a-2 cells, while in a mouse xenograft tumor model, it had an augmentative effect on tumor growth and metastasis and reduced the expression of the tumor-suppressor gene growth arrest and DNA damage-inducible 45α (GADD45α). Moreover, apoptosis was not significantly influenced by ABCE1 in vitro. In summary, we have provided evidence that ABCE1 plays an essential role in the progression and metastasis of lung cancers and may represent a valuable therapeutic target for the management of lung tumor.

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Acknowledgments

This study was supported by the Young Innovation and Development Foundation from the Fourth Affiliated Hospital of China Medical University and the National Nature Science Foundation of China (#30973502).

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Authors and Affiliations

  1. Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, 4 Chongshan East Road, Shenyang, 110032, China

    Ye Tian, Xu Han, Yong Chen, Cheng-Yang Song, Wen-Jun Jiang & Da-Li Tian

  2. Molecular Oncology Department of Cancer Research Institute, the First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Shenyang, 110001, China

    Xin Tian

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  1. Ye Tian
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Correspondence to Da-Li Tian.

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BALB/C nude mice were obtained from the animal facility of China Medical University and were treated according to the ethical guidelines of the institution.

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Tian, Y., Tian, X., Han, X. et al. ABCE1 plays an essential role in lung cancer progression and metastasis. Tumor Biol. 37, 8375–8382 (2016). https://doi.org/10.1007/s13277-015-4713-3

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  • DOI: https://doi.org/10.1007/s13277-015-4713-3

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