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Objective Uniaxial Identification of Transition Points in Non-Linear Materials: Sample Application to Porcine Coronary Arteries and the Dependency of Their Pre- and Post-Transitional Moduli with Position

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Abstract

Purpose

This study aimed to develop an objective method for the elastic characterisation of pre- and post-transitional moduli of left anterior descending (LAD) porcine coronary arteries.

Methods

Eight coronary arteries were divided into proximal, middle and distal test specimens. Specimens underwent uniaxial extension up to 3 mm. Force–displacement measurements were used to determine the induced true stress and stretch for each specimen. A local maximum of the stretch-true stress data was used to identify a transition point. Pre- and post-transitional moduli were calculated up to and from this point, respectively.

Results

The mean pre-transitional moduli for all specimens was 0.76 MPa, as compared to 4.86 MPa for the post-transitional moduli. However, proximal post-transitional moduli were significantly greater than that of middle and distal test specimens (p < 0.05).

Conclusion

Post-transitional uniaxial properties of the LAD are dependent on location along the artery. Further, it is feasible to objectively identify a transition point between pre- and post-transitional moduli.

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Acknowledgments

The authors would like to thank the Engineering and Physical Sciences Research Council for the studentship for HEB [EP/M114612B]. The equipment used in this study was funded by Arthritis Research UK [H0671].

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Authors and Affiliations

  1. Department of Mechanical Engineering, University of Birmingham, Birmingham, B15 2TT, UK

    Jenny M. Freij, Hanna E. Burton & Daniel M. Espino

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  1. Jenny M. Freij
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Contributions

JMF participated in the study’s design, performed mechanical testing and drafted the initial manuscript. HEB conceived the study, participated in its design, and edited the manuscript. DME conceived the study, participated in its design, and edited the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Daniel M. Espino.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

No animals were sacrificed specifically for this study. Porcine hearts were supplied by Fresh Tissue Supplies (Horsham, UK). Ethical approval was granted for this study by the University of Birmingham Research Support Group [ERN_15-0032].

Additional information

Associate Editors Dr. Ajit P. Yoganathan and Dr. Peter E. McHugh oversaw the review of this article.

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Freij, J.M., Burton, H.E. & Espino, D.M. Objective Uniaxial Identification of Transition Points in Non-Linear Materials: Sample Application to Porcine Coronary Arteries and the Dependency of Their Pre- and Post-Transitional Moduli with Position. Cardiovasc Eng Tech 10, 61–68 (2019). https://doi.org/10.1007/s13239-018-00395-x

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