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Nanomaterial-modified Hybrid Platforms for Precise Electrochemical Detection of Dopamine

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Abstract

Dopamine belongs to the class of catecholamine neurotransmitters which have vital roles in the human central nervous system. Due to its importance in signal transmission in the nervous system, the abnormal release of dopamine is critical for the development of a number of neurological diseases/disorders, including Parkinson’s diseases, attention deficit hyperactivity disorder, and even drug addiction. Hence, there is an utmost need to develop platforms for the quantitative detection of dopamine in the human body in a rapid, sensitive, and label-free manner. A variety of nanomaterials have been explored and integrated into dopamine sensing platforms; in particular, electrochemical sensors can enhance both the sensitivity and selectivity toward dopamine, with promising results. The aim of this review is to summarize recent research on nanomaterial-modified dopamine electrochemical sensor platforms, particularly those that use nanoparticle-, graphene composite-, and transition metal dichalcogenide-modified electrodes. The information presented in this review might motivate the discovery or extension of nanomaterials with beneficial properties for the development of biosensors to detect various neurotransmitters including dopamine.

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Acknowledgments

This study was funded by the National Research Foundation of Korea (NRF) [Grant No. 2016R1C1B1016088], by the Mid-career Researcher Program [Grant No. 2016R1A2B4014541], and by the Nano Material Technology Development Program (funded by the Korean Government (MSIP) [NRF-2014 M3A7B4051907].

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Authors and Affiliations

  1. School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Korea

    Intan Rosalina Suhito, Novi Angeline & Tae-Hyung Kim

  2. Integrative Research Centre for Two-Dimensional Functional Materials, Institute of Interdisciplinary Convergence Research, Chung-Ang University, Seoul, 06974, Korea

    Tae-Hyung Kim

Authors
  1. Intan Rosalina Suhito
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  2. Novi Angeline
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  3. Tae-Hyung Kim
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Correspondence to Tae-Hyung Kim.

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These authors contributed equally to this work.

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The authors declare no competing financial interests.

Author’s contributions

I.R.S, N.A and T,-H.K. searched references & collected information. I.R.S. and N.A. produce table, figures, and figure captions. T,- H.K. established the structure of manuscript. All authors wrote and reviewed the manuscript.

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Suhito, I.R., Angeline, N. & Kim, TH. Nanomaterial-modified Hybrid Platforms for Precise Electrochemical Detection of Dopamine. BioChip J 13, 20–29 (2019). https://doi.org/10.1007/s13206-019-3106-x

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  • DOI: https://doi.org/10.1007/s13206-019-3106-x

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