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Multi-electrochemical signal generation using metalloprotein based on selective surface modification

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Abstract

In this research, we demonstrate a simple method to generate a multi-peak in a single electrochemical signal for the application to bioelectronics devices. Myoglobin is used as a source of electrochemical signal, and its property of redox peak is controlled by the introduction of various chemical-linking materials. Based on controlled signals of myoglobin, multisignal having dual peak is achieved by the signal combination of six electrodes, which have different electrochemical signals by the modification of each electrode with different kinds of chemical linkers individually. For the device formation, selective immobilization process was performed by using reductive cleavage of pre-immobilized thiol group. As a result, the proposed concept shows simple and effective formation of a multi-signal in a single electrochemical signal as compared with other methods based on heterolayer and hybrid materials, and it can be directly applied to materialize practical bioelectronic devices such as a bio-logic gate or bio-computing system

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Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul, 04107, Republic of Korea

    Si-Youl Yoo, Jinho Yoon & Jeong-Woo Choi

  2. Department of Chemical Engineering, Hoseo University, Baebang, Asan, Chungnam, 31499, Republic of Korea

    Yong-Ho Chung

  3. School of Integrative Engineering, Chung-Ang University, Heukseokdong, Dongjak-gu, Seoul, 06974, Republic of Korea

    Junhong Min

Authors
  1. Yong-Ho Chung
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  2. Si-Youl Yoo
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  3. Jinho Yoon
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  4. Junhong Min
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  5. Jeong-Woo Choi
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Correspondence to Jeong-Woo Choi.

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Chung, YH., Yoo, SY., Yoon, J. et al. Multi-electrochemical signal generation using metalloprotein based on selective surface modification. BioChip J 11, 322–328 (2017). https://doi.org/10.1007/s13206-017-1409-3

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  • DOI: https://doi.org/10.1007/s13206-017-1409-3

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