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Tumors of the Posterior Elements of the Spine in Children—an Overview

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Abstract

In this narrative review, we aim to describe the clinical features, diagnosis, and management of common primary osseous tumors affecting the posterior elements of the spine in children. We searched PubMed, Mendeley, and Google Scholar using the terms primary osseous tumors of the spine in children, tumors of the posterior elements of the spine, and names of individual tumors. The clinical features, investigations, and treatment modalities were analyzed, and a narrative review of the topic was prepared. We have included 54 studies published in the last 20 years. The majority are isolated reports or case series. Tumors of the posterior elements of the spine are rare. They are common in children and the majority of them are benign. Pain and deformity are common presentations. It is better to perform thorough investigations of children complaining of back pain to rule out primary tumors of the posterior elements of the spine.

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References

  1. Ciftdemir M, Kaya M, Selcuk E, Yalniz E (2016) Tumors of the spine. WJO 7(2):109

    PubMed  PubMed Central  Google Scholar 

  2. Clarke MJ, Mendel E, Vrionis FD (2014) Primary spine tumors: diagnosis and treatment. Cancer Control 21(2):114–123

    PubMed  Google Scholar 

  3. Ravindra VM, Eli IM, Schmidt MH, Brockmeyer DL (2016) Primary osseous tumors of the pediatric spinal column: review of pathology and surgical decision making. FOC 41(2):E3

    Google Scholar 

  4. Kim HJ, McLawhorn AS, Goldstein MJ, Boland PJ (2012) Malignant osseous tumors of the pediatric spine. J Am Acad Orthop Surg 20(10):646–656

    PubMed  Google Scholar 

  5. Kouwenhoven JWM, Wuisman PIJM, Ploegmakers JF (2004) Headache due to an osteochondroma of the axis. Eur Spine J 13(8):746–749

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Rahman A, Bhandari PB, Hoque SU, Ansari A, Hossain AM (2012) Solitary osteochondroma of the atlas causing spinal cord compression: a case report and literature review. BMJ Case Rep 2012:bcr1220115435

    PubMed  PubMed Central  Google Scholar 

  7. Schmale GA, Hawkins DS, Rutledge J, Conrad EU (2010) Malignant progression in two children with multiple osteochondromas. Sarcoma 2010:1–7

    Google Scholar 

  8. Patnaik S, Jyotsnarani Y, Uppin S, Susarla R (2016) Imaging features of primary tumors of the spine: a pictorial essay. Indian J Radiol Imaging 26(2):279

    PubMed  PubMed Central  Google Scholar 

  9. Malghem J, Berg B, Nol H, Maldague B (1992) Benign osteochondromas and exostotic chondrosarcomas: evaluation of cartilage cap thickness by ultrasound. Skeletal Radiol. 21(1):33–7

    CAS  PubMed  Google Scholar 

  10. Beuckeleer LHLD, Schepper AMAD, Ramon F (1996) Magnetic resonance imaging of cartilaginous tumors: is it useful or necessary? Skeletal Radiol 25(2):137–141

    PubMed  Google Scholar 

  11. García-Ramos CL, Buganza-Tepole M, Obil-Chavarría CA, Reyes-Sánchez AA (2015) Spinal osteochondroma: diagnostic imaging and treatment. Case reports. Cir Cir (English Edition) 83(6):496–500

    Google Scholar 

  12. Rodallec MH, Feydy A, Larousserie F, Anract P, Campagna R, Babinet A, Zins M, Drapé J-L (2008) Diagnostic imaging of solitary tumors of the spine: what to do and say. Radiographics 28(4):1019–1041

    PubMed  Google Scholar 

  13. Gasbarrini A, Cappuccio M, Bandiera S, Amendola L, van Urk P, Boriani S (2011) Osteoid osteoma of the mobile spine. Spine 36(24):2089–2093

    PubMed  Google Scholar 

  14. Garg S, Khurjekar K, Bhatt H, Singla R, Goyal R (2015) Osteoid osteoma of the dorsal spine in 13-year-old boy: a case report with review of the literature. Clin Cancer Investig J.

  15. Zhang H, Niu X, Wang B, He S, Hao D (2016) Scoliosis secondary to lumbar osteoid osteoma. Medicine 95(47):e5362

    PubMed  PubMed Central  Google Scholar 

  16. Biswas D, Mal RK (2007) Dysphagia secondary to osteoid osteoma of the transverse process of the second cervical vertebra. Dysphagia 22(1):73–75

    CAS  PubMed  Google Scholar 

  17. Saifuddin A, White J, Sherazi Z, Shaikh MI, Natali C, Ransford AO (1998) Osteoid osteoma and osteoblastoma of the spine. Spine 23(1):47–53

    CAS  PubMed  Google Scholar 

  18. Harish S, Saifuddin A (2005) Imaging features of spinal osteoid osteoma with emphasis on MRI findings. Eur Radiol 15(12):2396–2403

    PubMed  Google Scholar 

  19. Kamao S, Fukushima T (1976) Angiographic demonstration of vertebral osteoid osteoma. Surg Neurol. 3:167–8

    Google Scholar 

  20. Hadjipavlou AG, Tzermiadianos MN, Kakavelakis KN, Lander P (2009) Percutaneous core excision and radiofrequency thermocoagulation for the ablation of osteoid osteoma of the spine. Eur Spine J 18(3):345–351

    PubMed  Google Scholar 

  21. Li Z, Zhao Y, Hou S, Mao N, Yu S, Hou T (2013) Clinical features and surgical management of spinal osteoblastoma: a retrospective study in 18 cases. PLoS ONE 8(9):e74635

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Wang L, Hu B, Wang L, Yang X, Liu L, Song Y (2017) A rare case of osteoblastoma combined with severe scoliosis deformity, coronal and sagittal imbalance. BMC Musculoskelet Disord 18(1):538

    PubMed  PubMed Central  Google Scholar 

  23. Stavridis SI, Pingel A, Schnake KJ, Kandziora F (2013) Diagnosis and treatment of a C2-osteoblastoma encompassing the vertebral artery. Eur Spine J 22(11):2504–2512

    PubMed  PubMed Central  Google Scholar 

  24. Kobayashi H, Shinoda Y, Ohki T, Kawano H (2015) Intercostal neuralgia as a symptom of an osteoblastoma in thoracic spine. BMJ Case Rep 2015:720

    Google Scholar 

  25. Yin H, Zhou W, Hongyu Yu, Li B, Zhang D, Zhipeng Wu, Liu T, Xiao J (2014) Clinical characteristics and treatment options for two types of osteoblastoma in the mobile spine: a retrospective study of 32 cases and outcomes. Eur Spine J 23(2):411–416

    PubMed  Google Scholar 

  26. Harrop JS, Schmidt MH, Boriani S, Shaffrey CI (2009) Aggressive “benign” primary spine neoplasms. Spine 34(Supplement):S39-47

    PubMed  Google Scholar 

  27. Boriani S, Amendola L, Bandiera S, Simoes CE, Alberghini M, Di Fiore M, Gasbarrini A (2012) Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases. Eur Spine J. 21(10):2003–10

    PubMed  PubMed Central  Google Scholar 

  28. Zileli M, Isik HS, Ogut FE, Is M, Cagli S, Calli C (2013) Aneurysmal bone cysts of the spine. Eur Spine J 22(3):593–601

    PubMed  Google Scholar 

  29. Cugati G, Pande A, Jain Pradeep K, Symss N, Ramamurthi R, VasudevanChakravarthy M (2015) Aneurysmal bone cyst of the lumbar spine. Asian J Neurosurg 10(3):216

    PubMed  PubMed Central  Google Scholar 

  30. Ibebuike K, Roussot M, Watt J, Skead G, Dunn R (2019) Diagnostic challenges and surgical management of coexistent osteoblastoma and aneurysmal bone cyst of the lumbar spine in a child: case report. Afr H Sci 19(2):2294

    Google Scholar 

  31. Chan MS, Wong Y-C, Yuen M-K, Lam D (2002) Spinal aneurysmal bone cyst causing acute cord compression without vertebral collapse: CT and MRI findings. Ped Radiol 32(8):601–604

    Google Scholar 

  32. Caro PA, Mandell GA, Stanton RP (1991) Aneurysmal bone cyst of the spine in children. MRI imaging at 0.5 tesla. Pediatr Radiol 21(2):114–6

    CAS  PubMed  Google Scholar 

  33. Gasbarrini A, Cappuccio M, Bandiera S, Amendola L, van Urk P, Boriani S (2011) Osteoid osteoma of the mobile spine. Spine 36(24):2089–2093

    PubMed  Google Scholar 

  34. Okuda A, Shigematsu H, Iwata E, Tanaka M, Morimoto Y, Masuda K, Ohbayashi C, Tanaka Y (2019) An aneurysmal bone cyst at T1 treated with bone grafts containing calcitonin and methylprednisolone. J Orthop Surg (Hong Kong) 27(2):230949901983962

    Google Scholar 

  35. Frassanito P, D’Onofrio GF, Pennisi G, Massimi L, Tamburrini G, Muto M et al (2019) Multimodal management of aggressive recurrent aneurysmal bone cyst of spine: case report and review of literature. World Neurosurgery 126:423–427

    PubMed  Google Scholar 

  36. Xiao L, Han SB, Si G, Yang SM, Wang CM, Jiang L, Wei F, Wu FL, Liu XG, Liu ZJ (2019) Percutaneous albumin/doxycycline injection versus open surgery for aneurysmal bone cysts in the mobile spine. Eur Spine J 28(6):1529–36

    Google Scholar 

  37. Parker J, Soltani S, Boissiere L, Obeid I, Gille O, Kieser DC (2019) ‹p›Spinal aneurysmal bone cysts (ABCs): optimal management‹/p›. ORR 11:159–166

    Google Scholar 

  38. Gutiérrez-González R, De Reina L, Saab A, Jiménez-Heffernan J, García-Uría J (2012) Chondromyxoid fibroma of the lumbar spine: case report and literature review. Eur Spine J 21(S4):458–462

    Google Scholar 

  39. Lopez-Ben R, Siegal GP, Hadley MN (2002) Chondromyxoid fibroma of the cervical spine: case report. Neurosurgery 50(2):409–411

    PubMed  Google Scholar 

  40. TaghipourZahir S, SefidrokhSharahjin N, SadluParizi F, Rahmani K (2015) Chondromyxoid fibroma of two cervical vertebrae with involvement of surrounding soft tissue: radiologic diagnostic dilemma. Iran J Radiol 12(4):e19273

    Google Scholar 

  41. Gutiérrez-González R, De Reina L, Saab A, Jiménez-Heffernan J, García-Uría J (2012) Chondromyxoid fibroma of the lumbar spine: case report and literature review. Eur Spine J 21(S4):458–462

    Google Scholar 

  42. Katonis P, Datsis G, Karantanas A, Kampouroglou A, Lianoudakis S, Licoudis S et al (2013) Spinal osteosarcoma. Clin Med Insights Oncol 7:99

    Google Scholar 

  43. Chen D, Lai Qi, Zhu J, Wan Z, Liu H, Dai M, Guo R, Zhang B (2018) Lumbar spinal canal osteosarcoma. Medicine 97(25):e11210

    PubMed  PubMed Central  Google Scholar 

  44. Murphey MD (2003) wan Jaovisidha S, Temple HT, Gannon FH, Jelinek JS, Malawer MM Telangiectatic osteosarcoma: radiologic-pathologic comparison. Radiology 229(2):545–553

    PubMed  Google Scholar 

  45. Feng D, Yang X, Liu T, Xiao J, Zhipeng Wu, Huang Q, Ma J, Huang W, Zheng W, Cui Z (2013) Osteosarcoma of the spine: surgical treatment and outcomes. World J Surg Onc 11(1):89

    Google Scholar 

  46. Gao L, Zhu Y, Shi X, Gao Z, Chen X (2019) Peripheral primitive neuroectodermal tumors: a retrospective analysis of 89 cases and literature review (Review). Oncol Lett. 2019:6885–6890

    Google Scholar 

  47. Gopalakrishnan C, Shrivastava A, Easwer H, Nair S (2012) Primary Ewing’s sarcoma of the spine presenting as acute paraplegia. J Pediatr Neurosci 7(1):64

    CAS  PubMed  PubMed Central  Google Scholar 

  48. Ilaslan H, Sundaram M, Unni KK, Dekutoski MB (2004) Primary Ewing’s sarcoma of the vertebral column. Skeletal Radiol. 33(9):506–13

    PubMed  Google Scholar 

  49. Widhe B, Widhe T (2000) Initial symptoms and clinical features in osteosarcoma and Ewing sarcoma*. J Bone Joint Surg-Am Vol 82(5):667–674

    CAS  Google Scholar 

  50. Jambhekar N, Desai S (2010) Pathology of Ewing’s sarcoma/PNET: current opinion and emerging concepts. Indian J Orthop 44(4):363

    PubMed  PubMed Central  Google Scholar 

  51. Hesla AC, Bruland ØS, Jebsen N, Styring E, Eriksson S, Tsagozis P (2019) Ewing sarcoma of the mobile spine; predictive factors for survival, neurological function and local control. A Scandinavian sarcoma group study with a mean follow-up of 12 years. J Bone Oncol 14:100

    Google Scholar 

  52. Dini LI, Mendonça R, Gallo P (2006) Primary Ewing’s sarcoma of the spine: case report. Arq Neuro-Psiquiatr 64(3a):654–659

    Google Scholar 

  53. Sharafuddin MJA, Haddad FS, Hitchon PW, Haddad SF, El-Khoury GY (1992) Treatment options in primary Ewingʼs sarcoma of the spine. Neurosurgery 30(4):610–618

    CAS  PubMed  Google Scholar 

  54. Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA (2009) Ewing’s sarcoma: standard and experimental treatment options. Curr Treat Options in Oncol 10(1–2):126–140

    Google Scholar 

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Authors and Affiliations

  1. Dept. Of Orthopedics, Govt. Medical College, Kozhikode, Kerala, PIN 673008, India

    Balaji Zacharia

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  1. Balaji Zacharia
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Appendix

Appendix

Fig. 7
figure 7

The preference of location of tumors affecting the posterior elements of the spine in children

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Zacharia, B. Tumors of the Posterior Elements of the Spine in Children—an Overview. Indian J Surg Oncol 15 (Suppl 1), 137–147 (2024). https://doi.org/10.1007/s13193-023-01729-5

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