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Beneficial effect of MPFF administration on the healing process of venous ulcer

  • Original Article
  • Published:
Hellenic Journal of Surgery

Abstract

Introduction

Venous hypertension underlies all clinical manifestations of chronic venous insufficiency (CVI). It is transmitted to the microcirculation and results in capillary changes which lead to edema, skin damage and eventually venous ulceration. The venoactive drugs are believed to have a therapeutic effect in venous disorders. This study evaluated the effect on the healing process of venous leg ulcers of systemic treatment with a semi-synthetic micronized purified flaνοnoid fraction (MPFF).

Material and Method

The study population comprised 60 patients with CVI and venous ulcer of the lower extremities, who were randomised into three groups, each of 20 patients. The patients in group Α, considered as the control group, used only elastic compression stockings. Group Β patients used elastic compression stockings and took MPFF 500mg orally, twice daily, until the complete healing of the ulcer. Group C used elastic compression stockings, and took MPFF 500mg twice daily until the complete healing of the ulcer, plus antibiotics. The ulcer healing rate was measured based on the healing index Η = (D0-Dx/D0) × 100, where D is the day from starting treatment. Venous blood samples were collected from each patient, before, and 20 and 40 days after the beginning of treatment, from the ulceration site and from an upper extremity vein (systemic circulation), for measurement of the white blood cells (WBCs).

Results

Healing time was statistically significantly shorter in groups Β and C than in the control group Α (p = 0.01 and p = 0.001, respectively). The difference between groups Β and C was not significant. Comparison between the initial blood sample and that after 20 days of treatment showed that the WBC trapping rate in the capillaries around the ulcer was reduced by half with the administration of MPFF.

Conclusion

Administration of MPFF has a beneficial effect on capillary permeability and improves the microcirculation, with particular effect on the WBCs trapped in the capillaries around the venous leg ulcer. As a consequence MPFF administration improves the healing rate of the venous ulcers.

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Authors and Affiliations

  1. Vascular Unit, 2nd Department of Surgery, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece

    Konstantina K. Katseni & Konstantinos Katsenis

  2. 1st Department of Surgery, Laikon Hospital, National and Kapodistrian University of Athens, Athens, Greece

    K. Bramis

  3. 215 Mesogeion Ave., 11525, Athens, Greece

    Konstantina K. Katseni

Authors
  1. Konstantina K. Katseni
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  2. K. Bramis
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  3. Konstantinos Katsenis
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Correspondence to Konstantina K. Katseni.

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Katseni, K.K., Bramis, K. & Katsenis, K. Beneficial effect of MPFF administration on the healing process of venous ulcer. Hellenic J Surg 89, 196–202 (2017). https://doi.org/10.1007/s13126-017-0415-1

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  • DOI: https://doi.org/10.1007/s13126-017-0415-1

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