Abstract
Cancer has proven to be a menace for researchers from the past few decades. Breast cancer is a form of cancer with the second-highest mortality rate in the world. It is the leading form of cancer among women worldwide. Lack of early detection mechanism and detection at terminal stages result in this high mortality rate. Present detection mechanisms, including mammography, x-rays, positron emission tomography, or biopsy, prove to be ineffective in detecting breast cancer at early stages. Sensor technology has given new hope for solving this problem. With the advent of nanotechnology, sensors have become more sensitive, specific, and cost-effective. The sensor innovation has offered to ascend to an excess of sensors that can be utilized for early discovery of breast cancer with high explicitness with backsliding cases in individual breast cancer patients. This review puts light on different sensors developed to detect breast cancer over the past few years.
Graphical abstract
Similar content being viewed by others
References
Mittal, S., Kaur, H., Gautam, N., & Mantha, A. K. (2017). Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies. Biosensors & Bioelectronics, 88, 217–231. https://doi.org/10.1016/j.bios.2016.08.028
RG Blanks MG Wallis RJ Alison RM Given-Wilson 2020 An analysis of screen-detected invasive cancers by grade in the English breast cancer screening programme: Are we failing to detect sufficient small grade 3 cancers? European Radiology https://doi.org/10.1007/s00330-020-07276-9
Mohammadi, S., Salimi, A., Hamd-Ghadareh, S., Fathi, F., & Soleimani, F. (2018). A FRET immunosensor for sensitive detection of CA 15–3 tumor marker in human serum sample and breast cancer cells using antibody functionalized luminescent carbon-dots and AuNPs-dendrimer aptamer as donor-acceptor pair. Analytical Biochemistry, 557, 18–26. https://doi.org/10.1016/j.ab.2018.06.008
Yedjou CG, Sims JN, Miele L, Noubissi F, Lowe L, Fonseca DD, Alo RA, Payton M, Tchounwou PB (2019) Health and Racial Disparity in Breast Cancer. In: Ahmad A (ed) Breast cancer metastasis and drug resistance: Challenges and progress. Springer International Publishing, Cham, pp 31–49. https://doi.org/10.1007/978-3-030-20301-6_3
Ghosh, A., & Das, D. (2015). X-ray structurally characterized sensors for ratiometric detection of Zn(2+) and Al(3+) in human breast cancer cells (MCF7): Development of a binary logic gate as a molecular switch. Dalton Transactions, 44(26), 11797–11804. https://doi.org/10.1039/c5dt01303h
Guo, A., Zhu, R., Ren, Y., Dong, J., & Feng, L. (2016). A “turn-on” fluorescent chemosensor for aluminum ion and cell imaging application. Spectrochimica Acta A Molecular and Biomolecular Spectroscopy, 153, 530–534. https://doi.org/10.1016/j.saa.2015.09.009
Peng, G., Hakim, M., Broza, Y. Y., Billan, S., Abdah-Bortnyak, R., Kuten, A., Tisch, U., & Haick, H. (2010). Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors. British Journal of Cancer, 103(4), 542–551. https://doi.org/10.1038/sj.bjc.6605810
Ayyildiz, M., Guclu, B., Yildiz, M. Z., & Basdogan, C. (2013). An optoelectromechanical tactile sensor for detection of breast lumps. IEEE Transactions on Haptics, 6(2), 145–155. https://doi.org/10.1109/TOH.2012.54
JS Crabtree L Miele 2018 Breast Cancer Stem Cells. Biomedicines 6 3 77 https://doi.org/10.3390/biomedicines6030077
Katwal, G., Paulose, M., Rusakova, I. A., Martinez, J. E., & Varghese, O. K. (2016). Rapid growth of zinc oxide nanotube-nanowire hybrid architectures and their use in breast cancer-related volatile organics detection. Nano Letters, 16(5), 3014–3021. https://doi.org/10.1021/acs.nanolett.5b05280
Majd, S. M., Salimi, A., & Ghasemi, F. (2018). An ultrasensitive detection of miRNA-155 in breast cancer via direct hybridization assay using two-dimensional molybdenum disulfide field-effect transistor biosensor. Biosensors & Bioelectronics, 105, 6–13. https://doi.org/10.1016/j.bios.2018.01.009
Bakshi, S. F., Guz, N., Zakharchenko, A., Deng, H., Tumanov, A. V., Woodworth, C. D., Minko, S., Kolpashchikov, D. M., & Katz, E. (2018). Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field. Nanoscale, 10(3), 1356–1365. https://doi.org/10.1039/c7nr08581h
Yoo, B., Kavishwar, A., Ross, A., Pantazopoulos, P., Moore, A., & Medarova, Z. (2016). In vivo detection of miRNA expression in tumors using an activatable nanosensor. Molecular Imaging and Biology, 18(1), 70–78. https://doi.org/10.1007/s11307-015-0863-3
Ivanov, Y. D., Pleshakova, T. O., Malsagova, K. A., Kozlov, A. F., Kaysheva, A. L., Shumov, I. D., Galiullin, R. A., Kurbatov, L. K., Popov, V. P., Naumova, O. V., Fomin, B. I., Nasimov, D. A., Aseev, A. L., Alferov, A. A., Kushlinsky, N. E., Lisitsa, A. V., & Archakov, A. I. (2018). Detection of marker miRNAs in plasma using SOI-NW biosensor. Sensors and Actuators B-Chemical, 261, 566–571. https://doi.org/10.1016/j.snb.2018.01.153
Wang, L. (2018). Microwave Sensors for Breast Cancer Detection. Sensors (Basel), 18(2), 1–17. https://doi.org/10.3390/s18020655
Khosravi F, Trainor P, Rai SN, Kloecker G, Wickstrom E, Panchapakesan B (2016) Label-free capture of breast cancer cells spiked in buffy coats using carbon nanotube antibody micro-arrays. Nanotechnology 27 (13):13LT02. https://doi.org/10.1088/0957-4484/27/13/13LT02
Fernandez-Baldo, M. A., Ortega, F. G., Pereira, S. V., Bertolino, F. A., Serrano, M. J., Lorente, J. A., Raba, J., & Messina, G. A. (2016). Nanostructured platform integrated into a microfluidic immunosensor coupled to laser-induced fluorescence for the epithelial cancer biomarker determination. Microchemical Journal, 128, 18–25. https://doi.org/10.1016/j.microc.2016.03.012
Jana S, Samanta S, Roy S, Qiu JT, Maikap S (2018) Novel IrO x / SiO 2 / W cross-point memory for lysyl-oxidase-like-2 ( LOXL2 ) breast cancer biomarker detection. 2018 International Symposium on VLSI Technology, Systems and Application (VLSI-TSA) 10:1–2
Ha, Y., Ko, S., Kim, I., Huang, Y., Mohanty, K., Huh, C., & Maynard, J. A. (2018). Recent advances incorporating superparamagnetic nanoparticles into immunoassays. ACS Appl Nano Mater, 1(2), 512–521. https://doi.org/10.1021/acsanm.7b00025
Thiagarajan, V., Madhurantakam, S., Sethuraman, S., Balaguru Rayappan, J. B., & Maheswari Krishnan, U. (2016). Nano interfaced biosensor for detection of choline in triple negative breast cancer cells. Journal of Colloid and Interface Science, 462, 334–340. https://doi.org/10.1016/j.jcis.2015.10.014
Yang, D., Liu, M., Xu, J., Yang, C., Wang, X., Lou, Y., He, N., & Wang, Z. (2018). Carbon nanosphere-based fluorescence aptasensor for targeted detection of breast cancer cell MCF-7. Talanta, 185, 113–117. https://doi.org/10.1016/j.talanta.2018.03.045
Ren, X., Yan, T., Zhang, S., Zhang, X., Gao, P., Wu, D., Du, B., & Wei, Q. (2014). Ultrasensitive dual amplification sandwich immunosensor for breast cancer susceptibility gene based on sheet materials. The Analyst, 139(12), 3061–3068. https://doi.org/10.1039/c4an00099d
Ribovski, L., Zucolotto, V., & Janegitz, B. C. (2017). A label-free electrochemical DNA sensor to identify breast cancer susceptibility. Microchemical Journal, 133, 37–42. https://doi.org/10.1016/j.microc.2017.03.011
Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003). Radical causes of cancer. Nature Reviews Cancer, 3(4), 276–285. https://doi.org/10.1038/nrc1046
Hilakivi-Clarke, L. (2000). Estrogens, BRCA1, and breast cancer. Cancer Research, 60(18), 4993–5001.
Hankinson, S. E., Willett, W. C., Manson, J. E., Colditz, G. A., Hunter, D. J., Spiegelman, D., Barbieri, R. L., & Speizer, F. E. (1998). Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. Journal of the National Cancer Institute, 90(17), 1292–1299. https://doi.org/10.1093/jnci/90.17.1292
Mousavisani, S. Z., Raoof, J. B., Turner, A. P. F., Ojani, R., & Mak, W. C. (2018). Label-free DNA sensor based on diazonium immobilisation for detection of DNA damage in breast cancer 1 gene. Sensors and Actuators B-Chemical, 264, 59–66. https://doi.org/10.1016/j.snb.2018.02.152
Pandya, H. J., Park, K., & Desai, J. P. (2015). Design and fabrication of a flexible MEMS-based electromechanical sensor array for breast cancer diagnosis. Journal of Micromechanics and Microengineering, 25(7), 75025. https://doi.org/10.1088/0960-1317/25/7/075025
Wang, W., Fan, X., Xu, S., Davis, J. J., & Luo, X. (2015). Low fouling label-free DNA sensor based on polyethylene glycols decorated with gold nanoparticles for the detection of breast cancer biomarkers. Biosensors & Bioelectronics, 71, 51–56. https://doi.org/10.1016/j.bios.2015.04.018
Perez, W. I., Soto, Y., Ramirez-Vick, J. E., & Melendez, E. (2015). Nanostructured gold dsDNA sensor for early detection of breast cancer by beta protein 1 (BP1). J Electroanal Chem (Lausanne), 751, 49–56. https://doi.org/10.1016/j.jelechem.2015.05.038
Salvo, P., Henry, O. Y., Dhaenens, K., Acero Sanchez, J. L., Gielen, A., Werne Solnestam, B., Lundeberg, J., O’Sullivan, C. K., & Vanfleteren, J. (2014). Fabrication and functionalization of PCB gold electrodes suitable for DNA-based electrochemical sensing. BioMedical Materials and Engineering, 24(4), 1705–1714. https://doi.org/10.3233/BME-140982
Benvidi A, Abbasi Z, Dehghan Tezerjani M, Banaei M, Zare HR, Molahosseini H, Jahanbani S (2018) A highly selective DNA sensor based on graphene oxide-silk fibroin composite and AuNPs as a probe oligonucleotide immobilization Platform3667. Acta Chimica Slovenica 65 (2):278–288. https://doi.org/10.17344/acsi.2017.3667
Campuzano, S., Torrente-Rodriguez, R. M., Lopez-Hernandez, E., Conzuelo, F., Granados, R., Sanchez-Puelles, J. M., & Pingarron, J. M. (2014). Magnetobiosensors based on viral protein p19 for microRNA determination in cancer cells and tissues. Angewandte Chemie (International ed. in English), 53(24), 6168–6171. https://doi.org/10.1002/anie.201403270
Vargas E, Povedano E, Montiel VR, Torrente-Rodriguez RM, Zouari M, Montoya JJ, Raouafi N, Campuzano S, Pingarron JM (2018) Single-step incubation determination of miRNAs in cancer cells using an amperometric biosensor based on competitive hybridization onto magnetic beads. Sensors (Basel) 18 (3). https://doi.org/10.3390/s18030863
Zhang, J., Wang, L. L., Hou, M. F., Xia, Y. K., He, W. H., Yan, A., Weng, Y. P., Zeng, L. P., & Chen, J. H. (2018). A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal DNA walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction. Biosensors & Bioelectronics, 102, 33–40. https://doi.org/10.1016/j.bios.2017.10.050
Perfezou, M., Turner, A., & Merkoci, A. (2012). Cancer detection using nanoparticle-based sensors. Chemical Society Reviews, 41(7), 2606–2622. https://doi.org/10.1039/c1cs15134g
Salahandish, R., Ghaffarinejad, A., Naghib, S. M., Majidzadeh, A. K., Zargartalebi, H., & Sanati-Nezhad, A. (2018). Nano-biosensor for highly sensitive detection of HER2 positive breast cancer. Biosensors & Bioelectronics, 117, 104–111. https://doi.org/10.1016/j.bios.2018.05.043
Hasanzadeh, M., Tagi, S., Solhi, E., Mokhtarzadeh, A., Shadjou, N., Eftekhari, A., & Mahboob, S. (2018). An innovative immunosensor for ultrasensitive detection of breast cancer specific carbohydrate (CA 15–3) in unprocessed human plasma and MCF-7 breast cancer cell lysates using gold nanospear electrochemically assembled onto thiolated graphene quantum dots. International Journal of Biological Macromolecules, 114, 1008–1017. https://doi.org/10.1016/j.ijbiomac.2018.03.183
Damiati, S., Peacock, M., Mhanna, R., Sopstad, S., Sleytr, U. B., & Schuster, B. (2018). Bioinspired detection sensor based on functional nanostructures of S-proteins to target the folate receptors in breast cancer cells. Sensors and Actuators B-Chemical, 267, 224–230. https://doi.org/10.1016/j.snb.2018.04.037
Pacheco, J. G., Rebelo, P., Freitas, M., Nouws, H. P. A., & Delerue-Matos, C. (2018). Breast cancer biomarker (HER2-ECD) detection using a molecularly imprinted electrochemical sensor. Sensors and Actuators B-Chemical, 273, 1008–1014. https://doi.org/10.1016/j.snb.2018.06.113
Arya, S. K., Zhurauski, P., Jolly, P., Batistuti, M. R., Mulato, M., & Estrela, P. (2018). Capacitive aptasensor based on interdigitated electrode for breast cancer detection in undiluted human serum. Biosensors & Bioelectronics, 102, 106–112. https://doi.org/10.1016/j.bios.2017.11.013
Li, X., Shen, C., Yang, M., & Rasooly, A. (2018). Polycytosine DNA electric-current-generated immunosensor for electrochemical detection of human epidermal growth factor receptor 2 (HER2). Analytical Chemistry, 90(7), 4764–4769. https://doi.org/10.1021/acs.analchem.8b00023
Xu, S., Nie, Y., Jiang, L., Wang, J., Xu, G., Wang, W., & Luo, X. (2018). Polydopamine nanosphere/gold nanocluster (Au NC)-based nanoplatform for dual color simultaneous detection of multiple tumor-related MicroRNAs with DNase-I-assisted target recycling amplification. Analytical Chemistry, 90(6), 4039–4045. https://doi.org/10.1021/acs.analchem.7b05253
Zhu, L., Zhang, Y., Xu, P., Wen, W., Li, X., & Xu, J. (2016). PtW/MoS2 hybrid nanocomposite for electrochemical sensing of H2O2 released from living cells. Biosensors & Bioelectronics, 80, 601–606. https://doi.org/10.1016/j.bios.2016.02.019
Veselinovic, J., Li, Z., Daggumati, P., & Seker, E. (2018). Electrically guided DNA immobilization and multiplexed DNA detection with nanoporous gold electrodes. Nanomaterials (Basel), 8(5), 351. https://doi.org/10.3390/nano8050351
Ali, M. A., Mondal, K., Jiao, Y., Oren, S., Xu, Z., Sharma, A., & Dong, L. (2016). Microfluidic immuno-biochip for detection of breast cancer biomarkers using hierarchical Composite of porous graphene and titanium dioxide nanofibers. ACS Applied Materials & Interfaces, 8(32), 20570–20582. https://doi.org/10.1021/acsami.6b05648
Carvajal, S., Fera, S. N., Jones, A. L., Baldo, T. A., Mosa, I. M., Rusling, J. F., & Krause, C. E. (2018). Disposable inkjet-printed electrochemical platform for detection of clinically relevant HER-2 breast cancer biomarker. Biosensors & Bioelectronics, 104, 158–162. https://doi.org/10.1016/j.bios.2018.01.003
Khan NI, Maddaus AG, Song E (2018) A low-cost inkjet-printed aptamer-based electrochemical biosensor for the selective detection of lysozyme. Biosensors (Basel) 8 (1). https://doi.org/10.3390/bios8010007
Hassanpour, S., Hasanzadeh, M., Saadati, A., Shadjou, N., Soleymani, J., & Jouyban, A. (2019). A novel paper based immunoassay of breast cancer specific carbohydrate (CA 15.3) using silver nanoparticles-reduced graphene oxide nano-ink technology: A new platform to construction of microfluidic paper-based analytical devices (μPADs) towards biomedical analysis. Microchemical Journal, 146, 345–358. https://doi.org/10.1016/j.microc.2019.01.018
Zouari, M., Campuzano, S., Pingarron, J. M., & Raouafi, N. (2017). Competitive RNA-RNA hybridization-based integrated nanostructured-disposable electrode for highly sensitive determination of miRNAs in cancer cells. Biosensors & Bioelectronics, 91, 40–45. https://doi.org/10.1016/j.bios.2016.12.033
Wu, L., Ji, H. W., Guan, Y. J., Ran, X., Ren, J. S., & Qu, X. G. (2017). A graphene-based chemical nose/tongue approach for the identification of normal, cancerous and circulating tumor cells. Npg Asia Materials, 9(3), e356–e356. https://doi.org/10.1038/am.2017.11
Wang, G., Xu, Q., Liu, L., Su, X., Lin, J., Xu, G., & Luo, X. (2017). Mixed self-assembly of polyethylene glycol and aptamer on polydopamine surface for highly sensitive and low-fouling detection of adenosine triphosphate in complex media. ACS Applied Materials & Interfaces, 9(36), 31153–31160. https://doi.org/10.1021/acsami.7b09529
Akter, R., Jeong, B., Choi, J. S., & Rahman, M. A. (2016). Ultrasensitive Nanoimmunosensor by coupling non-covalent functionalized graphene oxide platform and numerous ferritin labels on carbon nanotubes. Biosensors & Bioelectronics, 80, 123–130. https://doi.org/10.1016/j.bios.2016.01.035
Kaplan, M., Kilic, T., Guler, G., Mandli, J., Amine, A., & Ozsoz, M. (2017). A novel method for sensitive microRNA detection: Electropolymerization based doping. Biosensors & Bioelectronics, 92, 770–778. https://doi.org/10.1016/j.bios.2016.09.050
Shi, K., Dou, B., Yang, J., Yuan, R., & Xiang, Y. (2016). Cascaded strand displacement for non-enzymatic target recycling amplification and label-free electronic detection of microRNA from tumor cells. Analytica Chimica Acta, 916, 1–7. https://doi.org/10.1016/j.aca.2016.02.034
Qiu, Y., Wen, Q., Zhang, L., & Yang, P. (2016). Label-free and dynamic evaluation of cell-surface epidermal growth factor receptor expression via an electrochemiluminescence cytosensor. Talanta, 150, 286–295. https://doi.org/10.1016/j.talanta.2015.12.019
Alikhani, A., Gharooni, M., Abiri, H., Farokhmanesh, F., & Abdolahad, M. (2018). Tracing the pH dependent activation of autophagy in cancer cells by silicon nanowire-based impedance biosensor. Journal of Pharmaceutical and Biomedical Analysis, 154, 158–165. https://doi.org/10.1016/j.jpba.2018.02.040
Povedano, E., Vargas, E., Montiel, V. R., Torrente-Rodriguez, R. M., Pedrero, M., Barderas, R., Segundo-Acosta, P. S., Pelaez-Garcia, A., Mendiola, M., Hardisson, D., Campuzano, S., & Pingarron, J. M. (2018). Electrochemical affinity biosensors for fast detection of gene-specific methylations with no need for bisulfite and amplification treatments. Science and Reports, 8(1), 6418. https://doi.org/10.1038/s41598-018-24902-1
Wang, K., He, M. Q., Zhai, F. H., He, R. H., & Yu, Y. L. (2017). A novel electrochemical biosensor based on polyadenine modified aptamer for label-free and ultrasensitive detection of human breast cancer cells. Talanta, 166, 87–92. https://doi.org/10.1016/j.talanta.2017.01.052
Nawaz MA, Rauf S, Catanante G, Nawaz MH, Nunes G, Marty JL, Hayat A (2016) One step assembly of thin films of carbon nanotubes on screen printed interface for electrochemical aptasensing of breast cancer biomarker. Sensors (Basel) 16 (10). https://doi.org/10.3390/s16101651
Ahirwar, R., Dalal, A., Sharma, J. G., Yadav, B. K., Nahar, P., Kumar, A., & Kumar, S. (2019). An aptasensor for rapid and sensitive detection of estrogen receptor alpha in human breast cancer. Biotechnology and Bioengineering, 116(1), 227–233. https://doi.org/10.1002/bit.26819
Mouffouk, F., Aouabdi, S., Al-Hetlani, E., Serrai, H., Alrefae, T., & Leo Chen, L. (2017). New generation of electrochemical immunoassay based on polymeric nanoparticles for early detection of breast cancer. International Journal of Nanomedicine, 12, 3037–3047. https://doi.org/10.2147/IJN.S127086
Kieninger, J., Tamari, Y., Enderle, B., Jobst, G., Sandvik, J. A., Pettersen, E. O., & Urban, G. A. (2018). Sensor access to the cellular microenvironment using the sensing cell culture flask. Biosensors (Basel), 8(2), 1–11. https://doi.org/10.3390/bios8020044
Jolly, P., Batistuti, M. R., Miodek, A., Zhurauski, P., Mulato, M., Lindsay, M. A., & Estrela, P. (2016). Highly sensitive dual mode electrochemical platform for microRNA detection. Science and Reports, 6, 36719. https://doi.org/10.1038/srep36719
Lim, J. M., Ryu, M. Y., Yun, J. W., Park, T. J., & Park, J. P. (2017). Electrochemical peptide sensor for diagnosing adenoma-carcinoma transition in colon cancer. Biosensors & Bioelectronics, 98, 330–337. https://doi.org/10.1016/j.bios.2017.07.013
Lin, C. W., Wei, K. C., Liao, S. S., Huang, C. Y., Sun, C. L., Wu, P. J., Lu, Y. J., Yang, H. W., & Ma, C. C. (2015). A reusable magnetic graphene oxide-modified biosensor for vascular endothelial growth factor detection in cancer diagnosis. Biosensors & Bioelectronics, 67, 431–437. https://doi.org/10.1016/j.bios.2014.08.080
Gajasinghe, R., Jones, M., Ince, T. A., & Tigli, O. (2018). Label and immobilization free detection and differentiation of tumor cells. Ieee Sensors Journal, 18(9), 3486–3493. https://doi.org/10.1109/Jsen.2018.2813975
Dong, W., Ren, Y., Bai, Z., Yang, Y., Wang, Z., Zhang, C., & Chen, Q. (2018). Trimetallic AuPtPd nanocomposites platform on graphene: Applied to electrochemical detection and breast cancer diagnosis. Talanta, 189, 79–85. https://doi.org/10.1016/j.talanta.2018.06.067
Benvidi, A., Tezerjani, M. D., Jahanbani, S., Mazloum Ardakani, M., & Moshtaghioun, S. M. (2016). Comparison of impedimetric detection of DNA hybridization on the various biosensors based on modified glassy carbon electrodes with PANHS and nanomaterials of RGO and MWCNTs. Talanta, 147, 621–627. https://doi.org/10.1016/j.talanta.2015.10.043
Pallela, R., Chandra, P., Noh, H. B., & Shim, Y. B. (2016). An amperometric nanobiosensor using a biocompatible conjugate for early detection of metastatic cancer cells in biological fluid. Biosensors & Bioelectronics, 85, 883–890. https://doi.org/10.1016/j.bios.2016.05.092
Marques, R. C. B., Costa-Rama, E., Viswanathan, S., Nouws, H. P. A., Costa-Garcia, A., Delerue-Matos, C., & Gonzalez-Garcia, B. (2018). Voltammetric immunosensor for the simultaneous analysis of the breast cancer biomarkers CA 15–3 and HER2-ECD. Sensors and Actuators B-Chemical, 255, 918–925. https://doi.org/10.1016/j.snb.2017.08.107
Zhang, Y., Deng, D., Zhu, X., Liu, S., Zhu, Y., Han, L., & Luo, L. (2018). Electrospun bimetallic Au-Ag/Co3O4 nanofibers for sensitive detection of hydrogen peroxide released from human cancer cells. Analytica Chimica Acta, 1042, 20–28. https://doi.org/10.1016/j.aca.2018.07.065
Chocholova, E., Bertok, T., Lorencova, L., Holazova, A., Farkas, P., Vikartovska, A., Bella, V., Velicova, D., Kasak, P., Eckstein, A. A., Mosnacek, J., Hasko, D., & Tkac, J. (2018). Advanced antifouling zwitterionic layer based impedimetric HER2 biosensing in human serum: Glycoprofiling as a novel approach for breast cancer diagnostics. Sensors and Actuators B-Chemical, 272, 626–633. https://doi.org/10.1016/j.snb.2018.07.029
Ebrahimi, A., Nikokar, I., Zokaei, M., & Bozorgzadeh, E. (2018). Design, development and evaluation of microRNA-199a-5p detecting electrochemical nanobiosensor with diagnostic application in triple negative breast cancer. Talanta, 189, 592–598. https://doi.org/10.1016/j.talanta.2018.07.016
Hasanzadeh, M., Razmi, N., Mokhtarzadeh, A., Shadjou, N., & Mahboob, S. (2018). Aptamer based assay of plated-derived grow factor in unprocessed human plasma sample and MCF-7 breast cancer cell lysates using gold nanoparticle supported alpha-cyclodextrin. International Journal of Biological Macromolecules, 108, 69–80. https://doi.org/10.1016/j.ijbiomac.2017.11.149
Lin, C. E., Hiraka, K., Matloff, D., Johns, J., Deng, A., Sode, K., & La Belle, J. (2018). Development toward a novel integrated tear lactate sensor using Schirmer test strip and engineered lactate oxidase. Sensors and Actuators B-Chemical, 270, 525–529. https://doi.org/10.1016/j.snb.2018.05.061
Wang, Y., Ali, M. A., Chow, E. K. C., Dong, L., & Lu, M. (2018). An optofluidic metasurface for lateral flow-through detection of breast cancer biomarker. Biosensors & Bioelectronics, 107, 224–229. https://doi.org/10.1016/j.bios.2018.02.038
Ribeiro, J. A., Pereira, C. M., Silva, A. F., & Sales, M. G. F. (2018). Disposable electrochemical detection of breast cancer tumour marker CA 15–3 using poly(Toluidine Blue) as imprinted polymer receptor. Biosensors & Bioelectronics, 109, 246–254. https://doi.org/10.1016/j.bios.2018.03.011
Shahrokhian, S., & Salimian, R. (2018). Ultrasensitive detection of cancer biomarkers using conducting polymer/electrochemically reduced graphene oxide-based biosensor: Application toward BRCA1 sensing. Sensors and Actuators B-Chemical, 266, 160–169. https://doi.org/10.1016/j.snb.2018.03.120
Ou, D., Sun, D. P., Liang, Z. X., Chen, B. W., Lin, X. G., & Chen, Z. G. (2019). A novel cytosensor for capture, detection and release of breast cancer cells based on metal organic framework PCN-224 and DNA tetrahedron linked dual-aptamer. Sensors and Actuators B-Chemical, 285, 398–404. https://doi.org/10.1016/j.snb.2019.01.079
Shamsipur, M., Emami, M., Farzin, L., & Saber, R. (2018). A sandwich-type electrochemical immunosensor based on in situ silver deposition for determination of serum level of HER2 in breast cancer patients. Biosensors & Bioelectronics, 103, 54–61. https://doi.org/10.1016/j.bios.2017.12.022
Tang, Y. H., Lin, H. C., Lai, C. L., Chen, P. Y., & Lai, C. H. (2018). Mannosyl electrochemical impedance cytosensor for label-free MDA-MB-231 cancer cell detection. Biosensors & Bioelectronics, 116, 100–107. https://doi.org/10.1016/j.bios.2018.05.002
Tian, L., Qi, J. X., Qian, K., Oderinde, O., Liu, Q. Y., Yao, C., Song, W., & Wang, Y. H. (2018). Copper (II) oxide nanozyme based electrochemical cytosensor for high sensitive detection of circulating tumor cells in breast cancer. Journal of Electroanalytical Chemistry, 812, 1–9. https://doi.org/10.1016/j.jelechem.2017.12.012
Uliana, C. V., Peverari, C. R., Afonso, A. S., Cominetti, M. R., & Faria, R. C. (2018). Fully disposable microfluidic electrochemical device for detection of estrogen receptor alpha breast cancer biomarker. Biosensors & Bioelectronics, 99, 156–162. https://doi.org/10.1016/j.bios.2017.07.043
Azimzadeh, M., Rahaie, M., Nasirizadeh, N., Ashtari, K., & Naderi-Manesh, H. (2016). An electrochemical nanobiosensor for plasma miRNA-155, based on graphene oxide and gold nanorod, for early detection of breast cancer. Biosensors & Bioelectronics, 77, 99–106. https://doi.org/10.1016/j.bios.2015.09.020
Cardoso, A. R., Moreira, F. T. C., Fernandes, R., & Sales, M. G. F. (2016). Novel and simple electrochemical biosensor monitoring attomolar levels of miRNA-155 in breast cancer. Biosensors & Bioelectronics, 80, 621–630. https://doi.org/10.1016/j.bios.2016.02.035
Cui, M., Wang, Y., Wang, H. P., Wu, Y. M., & Luo, X. L. (2017). A label-free electrochemical DNA biosensor for breast cancer marker BRCA1 based on self-assembled antifouling peptide monolayer. Sensors and Actuators B-Chemical, 244, 742–749. https://doi.org/10.1016/j.snb.2017.01.060
Ghazizadeh, E., Naseri, Z., Jaafari, M. R., Forozandeh-Moghadam, M., & Hosseinkhani, S. (2018). A fires novel report of exosomal electrochemical sensor for sensing micro RNAs by using multi covalent attachment p19 with high sensitivity. Biosensors & Bioelectronics, 113, 74–81. https://doi.org/10.1016/j.bios.2018.04.023
Tabrizi, M. A., Shamsipur, M., Saber, R., Sarkar, S., & Zolfaghari, N. (2017). An ultrasensitive sandwich-type electrochemical immunosensor for the determination of SKBR-3 breast cancer cell using rGO-TPA/FeHCFnano labeled Anti-HCT as a signal tag. Sensors and Actuators B-Chemical, 243, 823–830. https://doi.org/10.1016/j.snb.2016.12.061
Zanghelini, F., Frias, I. A. M., Rego, M., Pitta, M. G. R., Sacilloti, M., Oliveira, M. D. L., & Andrade, C. A. S. (2017). Biosensing breast cancer cells based on a three-dimensional TIO2 nanomembrane transducer. Biosensors & Bioelectronics, 92, 313–320. https://doi.org/10.1016/j.bios.2016.11.006
Benvidi, A., & Jahanbani, S. (2016). Self-assembled monolayer of SH-DNA strand on a magnetic bar carbon paste electrode modified with Fe 3 O 4 @Ag nanoparticles for detection of breast cancer mutation. Journal of Electroanalytical Chemistry, 768, 47–54. https://doi.org/10.1016/j.jelechem.2016.02.038
Chen, L. H., Liu, X., & Chen, C. F. (2017). Impedimetric biosensor modified with hydrophilic material of tannic acid/polyethylene glycol and dopamine-assisted deposition for detection of breast cancer-related BRCA1 gene. Journal of Electroanalytical Chemistry, 791, 204–210. https://doi.org/10.1016/j.jelechem.2017.03.001
Saeed, A. A., Sanchez, J. L. A., O’Sullivan, C. K., & Abbas, M. N. (2017). DNA biosensors based on gold nanoparticles-modified graphene oxide for the detection of breast cancer biomarkers for early diagnosis. Bioelectrochemistry, 118, 91–99. https://doi.org/10.1016/j.bioelechem.2017.07.002
Fu, X. M., Liu, Z. J., Cai, S. X., Zhao, Y. P., Wu, D. Z., Li, C. Y., & Chen, J. H. (2016). Electrochemical aptasensor for the detection of vascular endothelial growth factor (VEGF) based on DNA-templated Ag/Pt bimetallic nanoclusters. Chinese Chemical Letters, 27(6), 920–926. https://doi.org/10.1016/j.cclet.2016.04.014
Rafiee-Pour, H. A., Behpour, M., & Keshavarz, M. (2016). A novel label-free electrochemical miRNA biosensor using methylene blue as redox indicator: Application to breast cancer biomarker miRNA-21. Biosensors & Bioelectronics, 77, 202–207. https://doi.org/10.1016/j.bios.2015.09.025
Li, S., Liu, C., Gong, H., Chen, C., Chen, X., & Cai, C. (2018). Simple G-quadruplex-based 2-aminopurine fluorescence probe for highly sensitive and amplified detection of microRNA-21. Talanta, 178, 974–979. https://doi.org/10.1016/j.talanta.2017.10.023
Eletxigerra, U., Martinez-Perdiguero, J., Merino, S., Barderas, R., Ruiz-Valdepeñas Montiel, V., Villalonga, R., Pingarrón, J. M., & Campuzano, S. (2016). Estrogen receptor α determination in serum, cell lysates and breast cancer cells using an amperometric magnetoimmunosensing platform. Sensing and Bio-Sensing Research, 7, 71–76. https://doi.org/10.1016/j.sbsr.2016.01.005
Nsabimana, A., Lan, Y. X., Du, F. X., Wang, C., Zhang, W., & Xu, G. B. (2019). Alkaline phosphatase-based electrochemical sensors for health applications. Analytical Methods, 11(15), 1996–2006. https://doi.org/10.1039/c8ay02793e
Augustine, S., Joshi, A. G., Yadav, B. K., Mehta, A., Kumar, P., Renugopalakrishanan, V., & Malhotra, B. D. (2018). An emerging nanostructured molybdenum trioxide-based biocompatible sensor platform for breast cancer biomarker detection. MRS Communications, 8(3), 668–679. https://doi.org/10.1557/mrc.2018.182
Hasanzadeh, M., Feyziazar, M., Solhi, E., Moichtarzadeh, A., Soleymani, J., Shadjou, N., Jouyban, A., & Mahboob, S. (2019). Ultrasensitive immunoassay of breast cancer type 1 susceptibility protein (BRCA1) using poly (dopamine-beta cyclodextrine-Cetyl trimethylammonium bromide) doped with silver nanoparticles: A new platform in early stage diagnosis of breast cancer and efficient management. Microchemical Journal, 145, 778–783. https://doi.org/10.1016/j.microc.2018.11.029
Ikhsan NI, Pandikumar A (2019) Doped-graphene modified electrochemical sensors. In: Graphene-Based Electrochemical Sensors for Biomolecules. pp 67–87. https://doi.org/10.1016/b978-0-12-815394-9.00003-0
Nasiri N, Clarke C (2019) Nanostructured Chemiresistive Gas Sensors for Medical Applications. Sensors (Basel) 19 (3). https://doi.org/10.3390/s19030462
Yang, M., Yi, X., Wang, J., & Zhou, F. (2014). Electroanalytical and surface plasmon resonance sensors for detection of breast cancer and Alzheimer’s disease biomarkers in cells and body fluids. The Analyst, 139(8), 1814–1825. https://doi.org/10.1039/c3an02065g
Sharpe, J. C., Mitchell, J. S., Lin, L., Sedoglavich, H., & Blaikie, R. J. (2008). Gold nanohole array substrates as immunobiosensors. Analytical Chemistry, 80(6), 2244–2249. https://doi.org/10.1021/ac702555r
Yavas, O., Acimovic, S. S., Garcia-Guirado, J., Berthelot, J., Dobosz, P., Sanz, V., & Quidant, R. (2018). Self-calibrating on-chip localized surface plasmon resonance sensing for quantitative and multiplexed detection of cancer markers in human serum. ACS Sens, 3(7), 1376–1384. https://doi.org/10.1021/acssensors.8b00305
Aadil, K. R., Barapatre, A., Meena, A. S., & Jha, H. (2016). Hydrogen peroxide sensing and cytotoxicity activity of Acacia lignin stabilized silver nanoparticles. International Journal of Biological Macromolecules, 82, 39–47. https://doi.org/10.1016/j.ijbiomac.2015.09.072
Gool, E. L., Stojanovic, I., Schasfoort, R. B. M., Sturk, A., van Leeuwen, T. G., Nieuwland, R., Terstappen, L., & Coumans, F. A. W. (2017). Surface plasmon resonance is an analytically sensitive method for antigen profiling of extracellular vesicles. Clinical Chemistry, 63(10), 1633–1641. https://doi.org/10.1373/clinchem.2016.271049
Chen, S. N., Zhao, Q., Zhang, L. Y., Wang, L. Q., Zeng, Y. L., & Huang, H. W. (2015). Combined detection of breast cancer biomarkers based on plasmonic sensor of gold nanorods. Sensors and Actuators B-Chemical, 221, 1391–1397. https://doi.org/10.1016/j.snb.2015.08.023
Washburn, A. L., Shia, W. W., Lenkeit, K. A., Lee, S. H., & Bailey, R. C. (2016). Multiplexed cancer biomarker detection using chip-integrated silicon photonic sensor arrays. The Analyst, 141(18), 5358–5365. https://doi.org/10.1039/c6an01076h
Sina, A. A., Vaidyanathan, R., Dey, S., Carrascosa, L. G., Shiddiky, M. J., & Trau, M. (2016). Real time and label free profiling of clinically relevant exosomes. Science and Reports, 6, 30460. https://doi.org/10.1038/srep30460
Eletxigerra, U., Martinez-Perdiguero, J., Barderas, R., Pingarron, J. M., Campuzano, S., & Merino, S. (2016). Surface plasmon resonance immunosensor for ErbB2 breast cancer biomarker determination in human serum and raw cancer cell lysates. Analytica Chimica Acta, 905, 156–162. https://doi.org/10.1016/j.aca.2015.12.020
Vergara, D., Bianco, M., Pagano, R., Priore, P., Lunetti, P., Guerra, F., Bettini, S., Carallo, S., Zizzari, A., Pitotti, E., Giotta, L., Capobianco, L., Bucci, C., Valli, L., Maffia, M., Arima, V., & Gaballo, A. (2018). An SPR based immunoassay for the sensitive detection of the soluble epithelial marker E-cadherin. Nanomedicine, 14(7), 1963–1971. https://doi.org/10.1016/j.nano.2018.05.018
Chen, H. X., Jia, S. S., Qi, F. J., Zou, F., Hou, Y. F., Koh, K., & Yin, Y. M. (2016). Fabrication of a simple and convenient surface plasmon resonance cytosensor based on oriented peptide on calix[4]arene crownether monolayer. Sensors and Actuators B-Chemical, 225, 504–509. https://doi.org/10.1016/j.snb.2015.11.046
Cai, B. J., Guo, S., & Li, Y. (2018). MoS2-based sensor for the detection of miRNA in serum samples related to breast cancer. Analytical Methods, 10(2), 230–236. https://doi.org/10.1039/c7ay02329d
Tang, Y., Wang, Z., Yang, X., Chen, J., Liu, L., Zhao, W., Le, X. C., & Li, F. (2015). Constructing real-time, wash-free, and reiterative sensors for cell surface proteins using binding-induced dynamic DNA assembly. Chemical Science, 6(10), 5729–5733. https://doi.org/10.1039/c5sc01870f
Hessels, A. M., Taylor, K. M., & Merkx, M. (2016). Monitoring cytosolic and ER Zn(2+) in stimulated breast cancer cells using genetically encoded FRET sensors. Metallomics, 8(2), 211–217. https://doi.org/10.1039/c5mt00257e
Xu, Q., Yuan, H., Dong, X., Zhang, Y., Asif, M., Dong, Z., He, W., Ren, J., Sun, Y., & Xiao, F. (2018). Dual nanoenzyme modified microelectrode based on carbon fiber coated with AuPd alloy nanoparticles decorated graphene quantum dots assembly for electrochemical detection in clinic cancer samples. Biosensors & Bioelectronics, 107, 153–162. https://doi.org/10.1016/j.bios.2018.02.026
Tiwari, D. K., Tanaka, S., Inouye, Y., Yoshizawa, K., Watanabe, T. M., & Jin, T. (2009). Synthesis and characterization of anti-HER2 Antibody conjugated CdSe/CdZnS quantum dots for fluorescence imaging of breast cancer cells. Sensors (Basel), 9(11), 9332–9364. https://doi.org/10.3390/s91109332
Elakkiya V, Menon MP, Nataraj D, Biji P, Selvakumar R (2017) Optical detection of CA 15.3 breast cancer antigen using CdS quantum dot. IET Nanobiotechnol 11 (3):268–276. https://doi.org/10.1049/iet-nbt.2016.0012
Li, K., Zhan, R., Feng, S. S., & Liu, B. (2011). Conjugated polymer loaded nanospheres with surface functionalization for simultaneous discrimination of different live cancer cells under single wavelength excitation. Analytical Chemistry, 83(6), 2125–2132. https://doi.org/10.1021/ac102949u
Yang, H., Liang, H. J., Xie, Y. W., & Chen, Q. Y. (2018). A cancer cell turn-on protein-CuSMn nanoparticle as the sensor of breast cancer cell and CH3O-PEG-phosphatide. Chinese Chemical Letters, 29(10), 1528–1532. https://doi.org/10.1016/j.cclet.2018.02.011
Hemmi, M., Ikeda, Y., Shindo, Y., Nakajima, T., Nishiyama, S., Oka, K., Sato, M., Hiruta, Y., Citterio, D., & Suzuki, K. (2018). Highly sensitive bioluminescent probe for thiol detection in living cells. Chemistry - An Asian Journal, 13(6), 648–655. https://doi.org/10.1002/asia.201701774
Tao, Y., & Auguste, D. T. (2016). Array-based identification of triple-negative breast cancer cells using fluorescent nanodot-graphene oxide complexes. Biosensors & Bioelectronics, 81, 431–437. https://doi.org/10.1016/j.bios.2016.03.033
Nguyen, P. D., Cong, V. T., Baek, C., & Min, J. (2017). Fabrication of peptide stabilized fluorescent gold nanocluster/graphene oxide nanocomplex and its application in turn-on detection of metalloproteinase-9. Biosensors & Bioelectronics, 89(Pt 1), 666–672. https://doi.org/10.1016/j.bios.2015.12.031
Chang, T. H., Tsai, M. F., Gow, C. H., Wu, S. G., Liu, Y. N., Chang, Y. L., Yu, S. L., Tsai, H. C., Lin, S. W., Chen, Y. W., Kuo, P. Y., Yang, P. C., & Shih, J. Y. (2017). Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2C. Cancer Letters, 402, 190–202. https://doi.org/10.1016/j.canlet.2017.06.002
Hizir, M. S., Robertson, N. M., Balcioglu, M., Alp, E., Rana, M., & Yigit, M. V. (2017). Universal sensor array for highly selective system identification using two-dimensional nanoparticles. Chemical Science, 8(8), 5735–5745. https://doi.org/10.1039/c7sc01522d
Xue, Z., Xiao, L., Chen, H., Zhou, T., Qian, Y., Suo, J., Hua, Q., Zhou, B., Ye, R., Bao, X., & Zhu, J. (2018). Synthesis and evaluation of a novel ‘off-on’ chemical sensor based on rhodamine B and the 2,5-pyrrolidinedione moiety for selective discrimination of glutathione and its bioimaging in living cells. Bioorganic & Medicinal Chemistry, 26(8), 1823–1831. https://doi.org/10.1016/j.bmc.2018.02.030
Lee, A., Kim, S. H., Lee, H., Kim, B., Kim, Y. S., & Key, J. (2018). Visualization of MMP-2 activity using dual-probe nanoparticles to detect potential metastatic cancer cells. Nanomaterials (Basel), 8(2), 1–12. https://doi.org/10.3390/nano8020119
Miura, T., Mikami, H., Isozaki, A., Ito, T., Ozeki, Y., & Goda, K. (2018). On-chip light-sheet fluorescence imaging flow cytometry at a high flow speed of 1 m/s. Biomedical Optics Express, 9(7), 3424–3433. https://doi.org/10.1364/BOE.9.003424
Densil, S., Chang, C. H., Chen, C. L., Mathavan, A., Ramdass, A., Sathish, V., Thanasekaran, P., Li, W. S., & Rajagopal, S. (2018). Aggregation-induced emission enhancement of anthracene-derived Schiff base compounds and their application as a sensor for bovine serum albumin and optical cell imaging. Luminescence, 33(4), 780–789. https://doi.org/10.1002/bio.3477
Geng, Y., Goel, H. L., Le, N. B., Yoshii, T., Mout, R., Tonga, G. Y., Amante, J. J., Mercurio, A. M., & Rotello, V. M. (2018). Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays. Nanomedicine, 14(6), 1931–1939. https://doi.org/10.1016/j.nano.2018.05.009
Choi, Y. E., Kwak, J. W., & Park, J. W. (2010). Nanotechnology for early cancer detection. Sensors (Basel), 10(1), 428–455. https://doi.org/10.3390/s100100428
Panesar, S., Weng, X., & Neethirajan, S. (2017). Toward point-of-care diagnostics of breast cancer: Development of an optical biosensor using quantum dots. IEEE Sensors Letters, 1(4), 1–4. https://doi.org/10.1109/lsens.2017.2727983
Borghei, Y. S., Hosseini, M., Ganjali, M. R., & Hosseinkhani, S. (2018). A novel BRCA1 gene deletion detection in human breast carcinoma MCF-7 cells through FRET between quantum dots and silver nanoclusters. Journal of Pharmaceutical and Biomedical Analysis, 152, 81–88. https://doi.org/10.1016/j.jpba.2018.01.014
Motaghi, H., Ziyaee, S., Mehrgardi, M. A., Kajani, A. A., & Bordbar, A. K. (2018). Electrochemiluminescence detection of human breast cancer cells using aptamer modified bipolar electrode mounted into 3D printed microchannel. Biosensors & Bioelectronics, 118, 217–223. https://doi.org/10.1016/j.bios.2018.07.066
Sharma, V., Kaur, N., Tiwari, P., & Mobin, S. M. (2018). Full color emitting fluorescent carbon material as reversible pH sensor with multicolor live cell imaging. Journal of Photochemistry and Photobiology B: Biology, 182, 137–145. https://doi.org/10.1016/j.jphotobiol.2018.04.006
Ke, H., Zhang, X., Huang, C., & Jia, N. (2018). Electrochemiluminescence evaluation for carbohydrate antigen 15–3 based on the dual-amplification of ferrocene derivative and Pt/BSA core/shell nanospheres. Biosensors & Bioelectronics, 103, 62–68. https://doi.org/10.1016/j.bios.2017.12.032
Xu, S., Gao, T., Feng, X., Fan, X., Liu, G., Mao, Y., Yu, X., Lin, J., & Luo, X. (2017). Near infrared fluorescent dual ligand functionalized Au NCs based multidimensional sensor array for pattern recognition of multiple proteins and serum discrimination. Biosensors & Bioelectronics, 97, 203–207. https://doi.org/10.1016/j.bios.2017.06.007
Zhang, Y., Xiao, J., Lv, Q., Wang, L., Dong, X., Asif, M., Ren, J., He, W., Sun, Y., Xiao, F., & Wang, S. (2017). In situ electrochemical sensing and real-time monitoring live cells based on freestanding nanohybrid paper electrode assembled from 3D functionalized graphene framework. ACS Applied Materials & Interfaces, 9(44), 38201–38210. https://doi.org/10.1021/acsami.7b08781
Liang, O., Wang, P., Xia, M., Augello, C., Yang, F., Niu, G., Liu, H., & Xie, Y. H. (2018). Label-free distinction between p53+/+ and p53 -/- colon cancer cells using a graphene based SERS platform. Biosensors & Bioelectronics, 118, 108–114. https://doi.org/10.1016/j.bios.2018.07.038
Fang, L., Trigiante, G., Kousseff, C. J., Crespo-Otero, R., Philpott, M. P., & Watkinson, M. (2018). Biotin-tagged fluorescent sensor to visualize ‘mobile’ Zn(2+) in cancer cells. Chemical Communications (Cambridge, England), 54(69), 9619–9622. https://doi.org/10.1039/c8cc05425h
Deshmukh, P. P., Navalkar, A., Maji, S. K., & Manjare, S. T. (2019). Phenylselenyl containing turn-on dibodipy probe for selective detection of superoxide in mammalian breast cancer cell line. Sensors and Actuators B-Chemical, 281, 8–13. https://doi.org/10.1016/j.snb.2018.10.072
Wang, Z. Y., Wang, L. J., Zhang, Q., Tang, B., & Zhang, C. Y. (2018). Single quantum dot-based nanosensor for sensitive detection of 5-methylcytosine at both CpG and non-CpG sites. Chemical Science, 9(5), 1330–1338. https://doi.org/10.1039/c7sc04813k
Mohammadinejad, A., Taghdisi, S. M., Es’haghi, Z., Abnous, K., & Mohajeri, S. A. (2019). Targeted imaging of breast cancer cells using two different kinds of aptamers -functionalized nanoparticles. European Journal of Pharmaceutical Sciences, 134, 60–68. https://doi.org/10.1016/j.ejps.2019.04.012
Kannan, S., Begoyan, V. V., Fedie, J. R., Xia, S., Weselinski, L. J., Tanasova, M., & Rao, S. (2018). Metabolism-driven high-throughput cancer identification with GLUT5-specific molecular probes. Biosensors (Basel), 8(2), 1–12. https://doi.org/10.3390/bios8020039
Fedie J, Kannan S, Begoyan V, Xia S, Shaikh S, Tanasova M, Rao S (2017) Fructose uptake-based rapid detection of breast cancer. 2017 IEEE Life Sciences Conference (LSC):162–165. https://doi.org/10.1109/LSC.2017.8268168
Hakimian, F., Ghourchian, H., Hashemi, A. S., Arastoo, M. R., & Behnam Rad, M. (2018). Ultrasensitive optical biosensor for detection of miRNA-155 using positively charged Au nanoparticles. Science and Reports, 8(1), 2943. https://doi.org/10.1038/s41598-018-20229-z
Peng, J., Lai, Y., Chen, Y., Xu, J., Sun, L., & Weng, J. (2017). Sensitive detection of carcinoembryonic antigen using stability-limited few-layer black phosphorus as an electron donor and a reservoir. Small (Weinheim an der Bergstrasse, Germany), 13(15), 1–11. https://doi.org/10.1002/smll.201603589
Miao, X., Ning, X., Li, Z., & Cheng, Z. (2016). Sensitive detection of miRNA by using hybridization chain reaction coupled with positively charged gold nanoparticles. Science and Reports, 6, 32358. https://doi.org/10.1038/srep32358
Feng, J., Wu, X., Ma, W., Kuang, H., Xu, L., & Xu, C. (2015). A SERS active bimetallic core–satellite nanostructure for the ultrasensitive detection of Mucin-1. Chemical Communications, 51(79), 14761–14763.
Zeng, L., Pan, Y., Wang, S., Wang, X., Zhao, X., Ren, W., Lu, G., & Wu, A. (2015). Raman Reporter-Coupled Ag(core)@Au(shell) Nanostars for in Vivo improved surface enhanced raman scattering imaging and near-infrared-triggered photothermal therapy in breast cancers. ACS Applied Materials & Interfaces, 7(30), 16781–16791. https://doi.org/10.1021/acsami.5b04548
Kaminska, A., Winkler, K., Kowalska, A., Witkowska, E., Szymborski, T., Janeczek, A., & Waluk, J. (2017). SERS-based immunoassay in a microfluidic system for the multiplexed recognition of interleukins from blood plasma: Towards picogram detection. Science and Reports, 7(1), 10656. https://doi.org/10.1038/s41598-017-11152-w
Zheng, Z., Wu, L., Li, L., Zong, S., Wang, Z., & Cui, Y. (2018). Simultaneous and highly sensitive detection of multiple breast cancer biomarkers in real samples using a SERS microfluidic chip. Talanta, 188, 507–515. https://doi.org/10.1016/j.talanta.2018.06.013
Zhang, X., Xu, S., Jiang, S., Wang, J., Wei, J., Xu, S., Gao, S., Liu, H., Qiu, H., Li, Z., Liu, H., Li, Z., & Li, H. (2015). Growth graphene on silver–copper nanoparticles by chemical vapor deposition for high-performance surface-enhanced Raman scattering. Applied Surface Science, 353, 63–70. https://doi.org/10.1016/j.apsusc.2015.06.084
Rong, Z., Wang, C., Wang, J., Wang, D., Xiao, R., & Wang, S. (2016). Magnetic immunoassay for cancer biomarker detection based on surface-enhanced resonance Raman scattering from coupled plasmonic nanostructures. Biosensors & Bioelectronics, 84, 15–21. https://doi.org/10.1016/j.bios.2016.04.006
Lee, J. U., Kim, W. H., Lee, H. S., Park, K. H., & Sim, S. J. (2019). Quantitative and specific detection of exosomal miRNAs for accurate diagnosis of breast cancer using a surface-enhanced raman scattering sensor based on plasmonic head-flocked gold nanopillars. Small (Weinheim an der Bergstrasse, Germany), 15(17), e1804968. https://doi.org/10.1002/smll.201804968
Sun, D., Ran, Y., & Wang, G. (2017). Label-free detection of cancer biomarkers using an in-line taper fiber-optic interferometer and a fiber bragg grating. Sensors (Basel), 17(11), 2559. https://doi.org/10.3390/s17112559
Akbari Khorami, H., Wild, P., Brolo, A. G., & Djilali, N. (2016). pH-dependent response of a hydrogen peroxide sensing probe. Sensors and Actuators B: Chemical, 237, 113–119. https://doi.org/10.1016/j.snb.2016.06.094
Ayyanar, N., Raja, G. T., Sharma, M., & Kumar, D. S. (2018). Photonic crystal fiber-based refractive index sensor for early detection of cancer. Ieee Sensors Journal, 18(17), 7093–7099. https://doi.org/10.1109/Jsen.2018.2854375
Sharma P, Deshmukh P (2015) A photonic crystal sensor for analysis and detection of cancer cells. 2
Faragasso, A., Bimbo, J., Stilli, A., Wurdemann, H. A., Althoefer, K., & Asama, H. (2018). Real-Time Vision-Based Stiffness Mapping (dagger). Sensors (Basel), 18(5), 1–13. https://doi.org/10.3390/s18051347
Etayash, H., Jiang, K., Azmi, S., Thundat, T., & Kaur, K. (2015). Real-time detection of breast cancer cells using peptide-functionalized microcantilever arrays. Science and Reports, 5, 13967. https://doi.org/10.1038/srep13967
Rasheed, P. A., & Sandhyarani, N. (2017). Electrochemical DNA sensors based on the use of gold nanoparticles: A review on recent developments. Microchimica Acta, 184(4), 981–1000. https://doi.org/10.1007/s00604-017-2143-1
Crivianu-Gaita, V., Aamer, M., Posaratnanathan, R. T., Romaschin, A., & Thompson, M. (2016). Acoustic wave biosensor for the detection of the breast and prostate cancer metastasis biomarker protein PTHrP. Biosensors & Bioelectronics, 78, 92–99. https://doi.org/10.1016/j.bios.2015.11.031
Xu, X., Chung, Y., Brooks, A. D., Shih, W. H., & Shih, W. Y. (2016). Development of array piezoelectric fingers towards in vivo breast tumor detection. Review of Scientific Instruments, 87(12), 124301. https://doi.org/10.1063/1.4971325
Pohanka M (2018) Overview of piezoelectric biosensors, immunosensors and DNA sensors and their applications. materials (Basel) 11 (3). https://doi.org/10.3390/ma11030448
Laufer, S., Rasske, K., Stopfer, L., Kurzynski, C., Abbott, T., Platner, M., Towles, J., & Pugh, C. M. (2016). Fabric force sensors for the clinical breast examination simulator. Stud Health Technol Inform, 220, 193–198. https://doi.org/10.3233/978-1-61499-625-5-193
Arcarisi L, Di Pietro L, Carbonaro N, Tognetti A, Ahluwalia A, De Maria C (2019) Palpreast—A new wearable device for breast self-examination. Applied Sciences 9 (3). https://doi.org/10.3390/app9030381
Strauch, M., Ludke, A., Munch, D., Laudes, T., Galizia, C. G., Martinelli, E., Lavra, L., Paolesse, R., Ulivieri, A., Catini, A., Capuano, R., & Di Natale, C. (2014). More than apples and oranges–detecting cancer with a fruit fly’s antenna. Science and Reports, 4, 3576. https://doi.org/10.1038/srep03576
Toneff, M. J., Sreekumar, A., Tinnirello, A., Hollander, P. D., Habib, S., Li, S., Ellis, M. J., Xin, L., Mani, S. A., & Rosen, J. M. (2016). The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biology, 14, 47. https://doi.org/10.1186/s12915-016-0269-y
Foroutan F, Nikolova NK (2018) Active sensor for microwave tissue imaging with Bias-Switched Arrays. Sensors (Basel) 18 (5). https://doi.org/10.3390/s18051447
Bahramiabarghouei, H., Porter, E., Santorelli, A., Gosselin, B., Popovic, M., & Rusch, L. A. (2015). Flexible 16 antenna array for microwave breast cancer detection. IEEE Transactions on Biomedical Engineering, 62(10), 2516–2525. https://doi.org/10.1109/TBME.2015.2434956
Mirza, A. F., See, C. H., Danjuma, I. M., Asif, R., Abd-Alhameed, R. A., Noras, J. M., Clarke, R. W., & Excell, P. S. (2017). An active microwave sensor for near field imaging. Ieee Sensors Journal, 17(9), 2749–2757. https://doi.org/10.1109/Jsen.2017.2673961
Khan M, Chatterjee D (2015) UWB microwave sensor array characterization for early detection of breast cancer.4–5
Afyf, A., Bellarbi, L., Yaakoubi, N., Gaviot, E., Camberlein, L., Latrach, M., & Sennouni, M. A. (2016). Novel antenna structure for early breast cancer detection. Procedia Engineering, 168, 1334–1337. https://doi.org/10.1016/j.proeng.2016.11.365
Santorelli, A., Porter, E., Kang, E., Piske, T., Popovic, M., & Schwartz, J. D. (2015). A Time-Domain microwave system for breast cancer detection using a flexible circuit board. Ieee Transactions on Instrumentation and Measurement, 64(11), 2986–2994. https://doi.org/10.1109/Tim.2015.2440565
Garduno-Ramon MA, Vega-Mancilla SG, Morales-Henandez LA, Osornio-Rios RA (2017) Supportive noninvasive tool for the diagnosis of breast cancer using a thermographic camera as sensor. Sensors (Basel) 17 (3). https://doi.org/10.3390/s17030497
Kaufman, Z., Paran, H., Haas, I., Malinger, P., Zehavi, T., Karni, T., Pappo, I., Sandbank, J., Diment, J., & Allweis, T. (2016). Mapping breast tissue types by miniature radio-frequency near-field spectroscopy sensor in ex-vivo freshly excised specimens. BMC Medical Imaging, 16(1), 57. https://doi.org/10.1186/s12880-016-0160-x
Liu, D., Liu, X., Zhang, Y., Wang, Q., & Lu, J. (2016). Tissue phantom-based breast cancer detection using continuous near-infrared sensor. Bioengineered, 7(5), 321–326. https://doi.org/10.1080/21655979.2016.1197747
Farag O, Mohamed M, Abd El Ghany M, Hofmann K (2018) Integrated sensors for early breast cancer diagnostics. 2018 IEEE 21st International Symposium on Design and Diagnostics of Electronic Circuits & Systems (DDECS):153–157. https://doi.org/10.1109/DDECS.2018.00034
Izumi S, Yamamura S, Hayashi N, Toma M, Tawa K (2017) Dual-color fluorescence imaging of EpCAM and EGFR in breast cancer cells with a bull’s eye-type plasmonic chip. Sensors (Basel) 17 (12). https://doi.org/10.3390/s17122942
Han, C., Zhang, A., Kong, Y., Yu, N., Xie, T., Dou, B., Li, K., Wang, Y., Li, J., & Xu, K. (2019). Multifunctional iron oxide-carbon hybrid nanoparticles for targeted fluorescent/MR dual-modal imaging and detection of breast cancer cells. Analytica Chimica Acta, 1067, 115–128. https://doi.org/10.1016/j.aca.2019.03.054
Funding
None.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of Interest
None.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Tiwari, A., Chaskar, J., Ali, A. et al. Role of Sensor Technology in Detection of the Breast Cancer. BioNanoSci. 12, 639–659 (2022). https://doi.org/10.1007/s12668-021-00921-7
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12668-021-00921-7