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Development of Novel Doxorubicin Loaded Biodegradable Polymeric Nanofibers as the Anticancer Drug Delivery Systems

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Abstract

Through the present research, for the first time, doxorubicin hydrochloride (DOX)-loaded poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) (PCL-PEG-PCL, PCEC) nanofibers were obtained by blending electrospinning method. The physicochemical characteristics of the DOX/PCEC nanofibers were fully evaluated. Nanofibers had homogeneous morphology with mean diameters ranging from 80 to 300 nm. The drug releasing behavior showed the faster release rate by increasing the drug content in nanofibers. The in vitro release profile and release kinetics from the DOX/PCEC nanofibers confirmed that the release profile followed Korsmeyer–Peppas model suggesting a Fickian diffusion as a major drug release mechanism.

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Acknowledgments

This work was financially supported by the “Department of Medical Nanotechnology, Faculty of Advanced Medical Science of Tabriz University” of Tabriz University of Medical Sciences. The authors thank the Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, for all support provided.

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Authors and Affiliations

  1. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Mohsen Bakhtiari

  2. Department of Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Mohsen Bakhtiari, Roya Salehi & Abolfazl Akbarzadeh

  3. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Roya Salehi

  4. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Abolfazl Akbarzadeh & Soodabeh Davaran

  5. Universal Scientific Education and Research Network (USERN), Tabriz, Iran

    Abolfazl Akbarzadeh

  6. Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems, Drohobych, Ukraine

    Abolfazl Akbarzadeh

Authors
  1. Mohsen Bakhtiari
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  2. Roya Salehi
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  3. Abolfazl Akbarzadeh
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  4. Soodabeh Davaran
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Corresponding authors

Correspondence to Abolfazl Akbarzadeh or Soodabeh Davaran.

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The authors declare that they have no conflict of interest.

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Bakhtiari, M., Salehi, R., Akbarzadeh, A. et al. Development of Novel Doxorubicin Loaded Biodegradable Polymeric Nanofibers as the Anticancer Drug Delivery Systems. BioNanoSci. 8, 60–66 (2018). https://doi.org/10.1007/s12668-017-0421-3

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  • DOI: https://doi.org/10.1007/s12668-017-0421-3

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