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Oral Vitamin B12 Versus Intra-Nasal Vitamin B12 in Transient Neurosensory Disturbances Following Third Molar Surgery: A Prospective Cohort Study

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Abstract

Purpose

The aim was to evaluate the clinical efficacy of intra-nasal vitamin B12 spray compared to oral B12 in the recovery of transient neurosensory disturbances of the lingual nerve post-mandibular third molar surgery.

Methods

Thirty patients, who experienced paresthesia of the tongue a day after mandibular third molar surgery, participated in this study. They were randomly divided into two groups: Group 1 (intra-nasal vitamin B12 spray) and Group 2 (oral vitamin B12). Clinical neurosensory tests were conducted at various intervals, and the Fisher's exact test was performed for group comparisons based on recovery.

Results

Out of the 30 patients (18 females and 12 males) with transient lingual neurosensory disturbances, after third molar extraction, 15 used the intra-nasal vitamin B12 spray, while the other 15 took oral vitamin B12 tablets. Significant recovery was observed in the nasal group compared to the oral group at POD 16 (p = 0.005) and POD 24 (p = 0.003)."

Conclusion

Intra-nasal vitamin B12 sprays were found to be conducive adjuvants to treat transient neurosensory disturbances following third molar surgery. Further studies on its routine application post-neurosensory complications are recommended.

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Abbreviations

IAN:

Inferior alveolar nerve

CNST/CNT:

Clinical neurosensory testing

BDNF:

Bone-derived neurotropic factors

VAS:

Visual analog scale

LNI:

Lingual nerve injury

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Funding

No funding was received for the study.

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Authors and Affiliations

  1. Meenakshi Cleft and Craniofacial Centre, Chennai, Tamil Nadu, India

    Jayanthi Lingaraj

  2. Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India

    D. Prabhu Shankar, Anantanarayanan Parameswaran & T. Srinivasa Prasad

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  1. Jayanthi Lingaraj
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  2. D. Prabhu Shankar
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  3. Anantanarayanan Parameswaran
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  4. T. Srinivasa Prasad
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Contributions

Jayanthi Lingaraj  was involved in conception, drafting of manuscript and writing—original draft. D. Prabhu Shankar  and T. Srinivasa Prasad  helped with review of manuscript. Anantanarayanan Parameswaran helped with statistics.

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Correspondence to D. Prabhu Shankar.

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Lingaraj, J., Prabhu Shankar, D., Parameswaran, A. et al. Oral Vitamin B12 Versus Intra-Nasal Vitamin B12 in Transient Neurosensory Disturbances Following Third Molar Surgery: A Prospective Cohort Study. J. Maxillofac. Oral Surg. (2024). https://doi.org/10.1007/s12663-024-02155-y

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