Abstract
Toxocariasis is an underestimated geohelminthic infection which shows respiratory changes concurrent with larval migration. The purpose of the present study was to detect Toxocara seropositivity in asthmatic and pneumonic children, and in turn to evaluate its association with the children clinical manifestations, laboratory test results, and sociodemographic risk factors. A total of 50 asthmatic, 50 pneumonic children and 50 healthy controls were subjected to stool analysis by direct wet mount and concentration techniques to exclude possible cross reactivity. Blood samples were collected for complete blood count and assessment of eosinophil count. Sera were examined for anti-Toxocara IgG antibodies, and measurement of total IgE level. Anti Toxocara IgG was detected in 27.3% (41/150) of the studied children. It was significantly higher in asthmatic group compared to controls (26%. p value = 0.033) and significantly highest in pneumonia group compared to both bronchial asthma group (46%. p value = 0.030) and control group (10%. p value = 0.001). There was a significant association between anti Toxocara IgG seroprevalence and each of eosinophilia, total IgE and both combined. Anti Toxocara IgG showed significant higher percentage in asthmatic children who recorded history of soil contact and pets contact as compared to control and pneumonic groups. Toxocara IgG seropositivity was highly associated with fever, cough, wheezes and dyspnea with statistical significance. Toxocara seropositivity has to be considered as a vital associated factor for asthmatic and pneumonic children, and eventually better to be considered in differential diagnosis by pediatricians. Further studies are still needed to explore the correlation between toxocariasis and different patient categories.
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The study was approved by Research Ethical Committee of Beni-Suef University, Faculty of Medicine, Egypt. Ethical approval certificate is registered under number FMBSUREC/08052022. Written informed consent was obtained from children's parents/guardians after detailed description of the study's purpose. Pediatricians were informed with children positive results to describe appropriate treatment.
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Abd El Wahab, W.M., Ali, M.I., Ibrahim, S.S. et al. Toxocariasis: potential association with bronchial asthma, and pneumonia among pediatric children. J Parasit Dis 47, 93–100 (2023). https://doi.org/10.1007/s12639-022-01543-w
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DOI: https://doi.org/10.1007/s12639-022-01543-w