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High free fatty acid levels are associated with stroke recurrence and poor functional outcome in Chinese patients with ischemic stroke

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The journal of nutrition, health & aging

Abstract

Background

The aim of this study is to investigate whether serum and cerebrospinal fluid (CSF) free fatty acid (FFA) levels are associated with outcome and recurrence in a cohort of patients with an acute ischemic stroke (AIS).

Methods

From December 2013 to May 2015, patients with first-ever AIS were included. FFA level and NIH stroke scale (NIHSS) were measured at the time of admission. Logistic regression analysis was used to evaluate the stroke outcome and recurrence according to FFA level. Clinical follow-up was performed at 6 month.

Results

In our study, we studied 296 patients (52.7% male). We have found a positive correlation between serum and CSF levels of FFA. Patients with a poor outcome and recurrence had significantly increased FFA serum and CSF levels on admission (all p<0.0001). Multivariate logistic regression analysis adjusted for common risk factors showed that FFA was an independent predictor of poor functional outcome and recurrence. Odds ratios (OR) values were more significant for the higher levels of FFA.

Conclusion

In summary, baseline serum and CSF FFA level were associated with stroke poor function outcome and recurrence, suggesting an effect of FFA on disease course in AIS.

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Authors and Affiliations

  1. Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine and Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, 310016, China

    Z. Niu & H. Hu

  2. Department of neurology, Shaoxing center Hospital, No.1, huayu Road, Shaoxing, 312030, China

    Fengyun Tang

Authors
  1. Z. Niu
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  2. H. Hu
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  3. Fengyun Tang
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Correspondence to Fengyun Tang.

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Niu, Z., Hu, H. & Tang, F. High free fatty acid levels are associated with stroke recurrence and poor functional outcome in Chinese patients with ischemic stroke. J Nutr Health Aging 21, 1102–1106 (2017). https://doi.org/10.1007/s12603-016-0852-5

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  • DOI: https://doi.org/10.1007/s12603-016-0852-5

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