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A study on neuroprotective effects of curcumin on the diabetic rat brain

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The journal of nutrition, health & aging

Abstract

The present study was aimed to study the neuroprotective therapeutic effect of curcumin on the male albino rat brain. Subarachnoid hemorrhage leads to severe mortality rate and morbidity, and oxidative stress is a crucial factor in subarachnoid hemorrhage. Therefore, we investigated the effect of curcumin on oxidative stress and glutamate and glutamate transporter-1 on a subarachnoid hemorrhage-induced male albino rats. The curcumin commonly used for the treatment and saline used for the control. Curcumin (10 mg/kg bwt) dissolved in saline and administered orally to the rats for one week. Glutamate, glutamate transporter-1, malondialdehyde (MDA), superoxide dismutase (SOD), catalase, glutathione reductase and lactate dehydrogenase (LDH) activities were determined. Glutamate level was lower in the curcumin-treated rats compared to their respective controls. Glutamate transporter-1 did not alter in the curcumin-treated rats compared to their controls. Glutamate transporter-1 protein expression is significantly reduced in the curcumin-treated rats. MDA levels decreased 18 and 29 % in the hippocampus and the cortex region respectively. SOD (17% and 32%), and catalase (19% and 24%) activities were increased in the curcumin-treated hippocampus and the cortex region respectively. Glutathione reductase (13% and 19%) and LDH (21% and 30%) activities were increased in the treated hippocampus and the cortex region respectively. The mRNA expression of NK-kB and TLR4 was significantly reduced following curcumin treatment. Taking all these data together, the curcumin found to be effective against oxidative stress and glutamate neurotoxicity in the male albino rats.

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Authors and Affiliations

  1. Department of Clinical Laboratory, Cangzhou Central Hospital of Hebei Province, No.16 Xinhuaxi Road, Cangzhou City, 061001, Hebei Province, P.R. China

    L. Zhang & Yi-Tang Zhu

  2. Department of Central Laboratory, Cangzhou Central Hospital, Cangzhou, 061001, China

    X.-J. Kong

  3. Department of Neurology, Cangzhou People’s Hospital, Cangzhou, 061001, China

    Z.-Q. Wang

  4. Department of Clinical Laboratory, Huanghua People’s Hospital, Huanghua, 061100, China

    F.-S. Xu

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  1. L. Zhang
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  2. X.-J. Kong
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  3. Z.-Q. Wang
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  4. F.-S. Xu
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  5. Yi-Tang Zhu
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Correspondence to Yi-Tang Zhu.

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These two authors contributed equally to this article.

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Zhang, L., Kong, XJ., Wang, ZQ. et al. A study on neuroprotective effects of curcumin on the diabetic rat brain. J Nutr Health Aging 20, 835–840 (2016). https://doi.org/10.1007/s12603-016-0723-0

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  • DOI: https://doi.org/10.1007/s12603-016-0723-0

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