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Elderly Japanese Standard Data of Echocardiography; From J-LONG study

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Abstract

Background

Age-related changes in cardiac morphology and function have not been unknown in the elderly. The Japanese eLderly data Of Normal echocardioGraphy (J-LONG) study is a prospective multicenter cohort study and aimed to investigate the echocardiographic data in the healthy Japanese elderly.

Methods

Thirty domestic facilities participated in this study, and 130 healthy subjects (57 men, 73 women, 79.6 ± 4.7 years, range 75–98 years, interquartile range 76–82 years) were enrolled in this cohort. Echocardiographic and clinical data sets were obtained in each facility, and total analyses were performed in the University of Tsukuba.

Results

Almost all cardiac morphological data were significantly larger in men than those in women. However, corrected data by body surface area (BSA) were similar or closer between genders. As a gender difference, the negative correlation between BSA and age was observed in women only (r = − 0.46, p < 0.001), showing the independent determinant of women’s left ventricular end-diastolic volume (LVEDV) was age (β = − 0.29, p = 0.01), but not BSA. In men, LVEDV was significantly correlated with BSA (β = 0.42, p = 0.001), but not with age (p = 0.10).

Also, women had higher LV ejection fraction (70 ± 7.1 vs. 68 ± 4.9%, p = 0.02), lower E/A (0.67 ± 0.16 vs. 0.75 ± 0.21, p = 0.02), and higher E/eʹ (10 ± 2.7 vs. 8.9 ± 2.5, p = 0.03) as compared to men.

Conclusions

The J-LONG study suggested that correction by the physique was needed to interpret echocardiographic data of the elderly. Also, gender differences and age-related changes in cardiac morphology and function were observed, and further studies are needed to confirm the clinical significance.

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Acknowledgements

The J-LONG Study investigators are as follows: Masako Asakawa (JR Tokyo General Hospital, Tokyo), Chikage Oshita (JR Hiroshima Hospital, Hiroshima), Masanori Takada (Kawasaki Hospital, Hyogo), Mitsufumi Furuya (Koyama Memorial Hospital, Ibaraki), Fumiko Sakamaki, Hitomi Hashimoto (Tsukuba Central Hospital, Ibaraki), Takako Minami (Nagasaki University Hospital, Nagasaki), Harutoshi Tamura (Yamagata University School of Medicine, Yamagata), Akiko Okunaga, Yuichi Oshima (Kinki Central Hospital, Hyogo), Yoshie Omori (Nikko Memorial Hospital, Hokkaido), Takuma Aoyama (Kizawa Memorial Hospital, Gifu), Takako Iino (Akita University Graduate School of Medicine, Akita), Makoto Saito (Kitaishikai Hospital, Ehime), Tetsuya Kasuga (Nanpeidai Medical Clinic, Ibaraki), Taro Minagawa (Minagawa Clinic, Gifu), Satoshi Kibira (Kibira Medical Clinic, Akita), Hidekazu Tanaka (Kobe University Graduate School of Medicine, Hyogo), Yoshihisa Horizoe (Ebino City Hospital, Miyazaki), Hiroyoshi Yamamoto, Shintaro Beppu (Osaka Minato Central Hospital), Misun Pak (Shimane University Faculty of Medicine, Shimane), Miyako Nagumo (National Hospital Organization Saitama Hospital, Saitama), Masaki Izumo (St. Marianna University School of Medicine, Kanagawa), Atsushi Kobayashi (Fukushima Medical University, Fukushima), Shohei Kikuchi (Nagoya City University Graduate School of Medical Sciences, Aichi), Noriaki Iwahashi (Yokohama City University Medical Center, Kanagawa), Kotaro Numaguchi (National Hospital Orga nization Kyushu Medical Center, Fukuoka), Toshinari Onishi (Osaka University Graduate School of Medicine, Osaka), Yuki Izumi (Nippon Medical School, Tokyo), Hirotsugu Yamada, Kenya Kusunose (Tokushima University Graduate School of Biomedical Sciences, Tokushima), Hideo Kawakami (Ehime Prefectural Imabari Hospital, Ehime), and Hiroyuki Iwano (Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido).

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Authors and Affiliations

  1. Department of Cardiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan

    Yoshihiro Seo & Nobuyuki Ohte

  2. Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Tomoko Ishizu & Masaki Ieda

Authors
  1. Yoshihiro Seo
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  2. Tomoko Ishizu
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  3. Masaki Ieda
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  4. Nobuyuki Ohte
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Consortia

J-LONG Study Investigators

  • Masako Asakawa
  • , Chikage Oshita
  • , Masanori Takada
  • , Mitsufumi Furuya
  • , Fumiko Sakamaki
  • , Hitomi Hashimoto
  • , Takako Minami
  • , Harutoshi Tamura
  • , Akiko Okunaga
  • , Yuichi Oshima
  • , Yoshie Omori
  • , Takuma Aoyama
  • , Takako Iino
  • , Makoto Saito
  • , Tetsuya Kasuga
  • , Taro Minagawa
  • , Satoshi Kibira
  • , Hidekazu Tanaka
  • , Yoshihisa Horizoe
  • , Hiroyoshi Yamamoto
  • , Shintaro Beppu
  • , Misun Pak
  • , Miyako Nagumo
  • , Masaki Izumo
  • , Atsushi Kobayashi
  • , Shohei Kikuchi
  • , Noriaki Iwahashi
  • , Kotaro Numaguchi
  • , Toshinari Onishi
  • , Yuki Izumi
  • , Hirotsugu Yamada
  • , Kenya Kusunose
  • , Hideo Kawakami
  •  & Hiroyuki Iwano

Corresponding author

Correspondence to Yoshihiro Seo.

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Conflict of interest

This study was approved as an academic project of the Japanese Society of Echocardiography and was supported by a grant from the Japanese Society of Echocardiography. Besides, this study was supported by JSPS KAKENHI Grant Number JP16K09417.

Human rights statements and informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients for being included in the study.

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The members of J-LONG Study investigators are listed in the Acknowledgements section.

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Seo, Y., Ishizu, T., Ieda, M. et al. Elderly Japanese Standard Data of Echocardiography; From J-LONG study. J Echocardiogr 18, 175–182 (2020). https://doi.org/10.1007/s12574-020-00469-7

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  • DOI: https://doi.org/10.1007/s12574-020-00469-7

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