Skip to main content

Advertisement

Log in

Left ventricular hypertrophy and spontaneous rupture of the Achilles tendon after anabolic steroids in bodybuilder

  • Case Report
  • Published:
European Orthopaedics and Traumatology

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Ahlgrim C, Guglin M (2009) Anabolics and cardiomyopathy in a bodybuilder: case report and literature review. J Card Fail 15(6):496–500

    Article  PubMed  Google Scholar 

  2. Giannotti S, Bottai V, Ghilardi M, Dell’osso G, Fazzi R, Trombi L, Petrini M, Guido G (2013) Treatment of pseudoarthrosis of the upper limb using expanded mesenchymal stem cells: a pilot study. Eur Rev Med Pharmacol Sci 17:224–227

    CAS  PubMed  Google Scholar 

  3. Freeman BJC, Rooker GD (1995) Spontaneous rupture of the anterior cruciate ligament after anabolic steroids. Br J Sports Med 29:274–275

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Wood TO, Cooke PH, Goodship AE (1988) The effect of exercise and anabolic steroids on the mechanical properties and crimp morphology of the rat tendon. Am J Sports Med 16:153–158

    Article  CAS  PubMed  Google Scholar 

  5. Haines JF (1983) Bilateral rupture of the Achilles tendon in patients on steroid therapy. Ann Rheum Dis 42:652–654

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Jarvinen T, Kannus P, Mafulli N et al (2005) Achilles tendon disorders: etiology and epidemiology. Foot Ankle Clin 10:255–266

    Article  PubMed  Google Scholar 

  7. Clement DB, Tauntonn JE, Smart GW (1984) Achilles tendonitis and peritendinitis: etiology and treatment. Am J Sports Med 12:179–184

    Article  CAS  PubMed  Google Scholar 

  8. Van der Linden PD, Sturkenboom MC, Herings RM, Leufkens HM, Rowlands S, Stricker BH (2003) Increased risk of Achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids. Arch Intern Med 163:1801–1807

    Article  PubMed  Google Scholar 

  9. Kelly M, Dodds M, Huntley JS, Robinson CM (2004) Bilateral concurrent rupture of the Achilles tendon in the absence of risk factors. Hosp Med 65:310–311

    Article  CAS  PubMed  Google Scholar 

  10. Khanzada et al (2011) Bilateral spontaneous non-traumatic rupture of the Achilles tendon: a case report. J Med Case Reports 5:263

    Article  PubMed Central  Google Scholar 

  11. Parmar C, Meda KP (2007 Dec) Achilles tendon rupture associated with combination therapy of levofloxacin and steroid in four patients and a review of the literature. Foot Ankle Int 28(12):1287–1289. doi:10.3113/FAI.2007.1287

  12. Battista V, Combs J, Warme WJ (2003) Asynchronous bilateral Achilles tendon ruptures and androstenediol use. Am J Sports Med 31(6):1007–1009

    PubMed  Google Scholar 

  13. Marqueti RC, Prestes J, Wang CC, Ramos OH, Perez SE, Nakagaki WR, Carvalho HF, Selistre-de-Araujo HS (2011) Biomechanical responses of different rat tendons to nandrolone decanoate and load exercise. Scand J Med Sci Sports 21(6):e91–e99. doi:10.1111/j.1600-0838.2010.01162.x, Epub 2010 Jul 29

    Article  CAS  PubMed  Google Scholar 

  14. Marqueti RC, Parizotto NA, Chriguer RS, Perez SE, Selistre-de-Araujo HS (2006) Androgenic-anabolic steroids associated with mechanical loading inhibit matrix metallopeptidase activity and affect the remodeling of the Achilles tendon in rats. Am J Sports Med 34(8):1274–1280

    Article  PubMed  Google Scholar 

  15. Seynnes OR, Kamandulis S, Kairaitis R, Helland C, Campbell EL, Brazaitis M, Skurvydas A, Narici MV (2013) Effect of androgenic-anabolic steroids and heavy strength training on patellar tendon morphological and mechanical properties. J Appl Physiol 115(1):84–89. doi:10.1152/japplphysiol.01417.2012

    Article  PubMed  Google Scholar 

  16. Isenberg J, Prokop A, Skouras E (2008) Successive ruptures of patellar and Achilles tendons. Anabolic steroids in competitive sports. Unfallchirurg 111(1):46–49

    Article  CAS  PubMed  Google Scholar 

  17. Bispo M, Valente A, Maldonado R, Palma R, Glória H, Nóbrega J, Alexandrino P (2009 June 21) Anabolic steroid-induced cardiomyopathy underlying acute liver failure in a young bodybuilder. World J Gastroenterol 15(23):2920–2922

    Google Scholar 

  18. Dickerman RD, Schaller F, Prather I, McConathy WJ (1995) Sudden cardiac death in a 20-year-old bodybuilder using anabolic steroids. Cardiology 86:172–173. doi:10.1159/000176867

    Article  CAS  PubMed  Google Scholar 

  19. Ferrera PC, Putnam DL, Verdile VP (1997) Anabolic steroid use as the possible precipitant of dilated cardiomyopathy. Cardiology 88(2):218–220

    Article  CAS  PubMed  Google Scholar 

  20. Hassan AF, Kamal MM (2013 Jan) Effect of exercise training and anabolic androgenic steroids on hemodynamics, glycogen content, angiogenesis and apoptosis of cardiac muscle in adult male rats. Int J Health Sci (Qassim) 7(1):47–60

    Google Scholar 

  21. Schollert PV, Bendixen PM (1993) Dilated cardiomyopathy in a user of anabolic steroids. Ugeskr Laeger 155(16):1217–1218

    CAS  PubMed  Google Scholar 

  22. Marsh et al (1998) Androgen receptors mediate hypertrophy in cardiac myocytes. Circulation 98:256

    Article  CAS  PubMed  Google Scholar 

  23. McKillop G, Ballantyne D (1987) Lipoprotein analysis in bodybuilders. Int J Cardiol 17:281–288

    Article  CAS  PubMed  Google Scholar 

  24. Melchert RB, Welder AA (1995) Cardiovascular effects of androgenic-anabolic steroids. Med Sci Sports Exerc 27:1252–1262

    Article  CAS  PubMed  Google Scholar 

  25. D’Andrea A, Caso P, Salerno G, Scarafile R, De Corato G, Mita C, Di Salvo G, Severino S, Cuomo S, Liccardo B et al (2007) Left ventricular early myocardial dysfunction after chronic misuse of anabolic androgenic steroids: a Doppler myocardial and strain imaging analysis. Br J Sports Med 41:149–155

    Article  PubMed Central  PubMed  Google Scholar 

  26. Nieminen MS, Rämo MP, Viitasalo M et al (1996) Serious cardiovascular side effects of large doses of anabolic steroids in weight lifters. Eur Heart J 17:1576–1583

    Article  CAS  PubMed  Google Scholar 

  27. Krieg M, Smith K, Bartsch W (1978) Demonstration of a specific androgen receptor in rat heart muscle: relationship between binding, metabolism, and tissue levels of androgens. Endocrinology 103:1686–1694

    Article  CAS  PubMed  Google Scholar 

  28. Di Paolo M, Agozzino M, Toni C, Bassi LA, Molendini L, Scaglione M, Inzani F, Pasotti M, Buzzi F, Arbustini E (2007) Sudden anabolic steroid abuse-related death in athletes. Int J Cardiol 114:114–117

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

None of the authors has any conflict of interests to disclose.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stefano Giannotti.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Giannotti, S., Ghilardi, M., Dell’Osso, G. et al. Left ventricular hypertrophy and spontaneous rupture of the Achilles tendon after anabolic steroids in bodybuilder. Eur Orthop Traumatol 5, 363–365 (2014). https://doi.org/10.1007/s12570-013-0242-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12570-013-0242-y

Keywords

Navigation