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Successful pregnancy by vitrified–warmed embryo transfer for a woman with Kallmann syndrome

  • Case Report
  • Published:
Reproductive Medicine and Biology

Abstract

Purpose

Kallmann syndrome is a genetic disorder characterized by hypogonadotropic hypogonadism and anosmia. We report the case of a 31-year-old woman with Kallmann syndrome who successfully gave birth after intracytoplasmic sperm injection (ICSI) and vitrified–warmed embryo transfer, despite relatively ineffective ovarian stimulation.

Method

A 30 year-old woman with primary amenorrhea wished to achieve pregnancy. Diagnostic testing results were consistent with Kallmann syndrome. Follicular stimulation was started with human menopausal gonadotropin (hMG; 150 IU/day). After 28 days of treatment, 4 follicles were observed (total hMG; 4200 IU), with a dominant follicle diameter of 23 mm. Ovum pick-up was performed and 2 oocytes, one at metaphase II (MII) and one at the germinal vesicle stage, were obtained. Piezo-ICSI was performed on the MII oocyte and an 8-cell stage embryo was cryopreserved on day 3. Subsequently, embryo transfer was performed after endometrial preparation.

Result

A gestational sac and embryo heart activity were confirmed by ultrasonographic monitoring, and a healthy male infant weighing 3246 g was delivered by Caesarean section after 41 weeks 3 days of gestation.

Conclusion

This is the first report of a healthy delivery after vitrified–warmed embryo transfer for a woman with Kallmann syndrome. Our experience suggests that ICSI and vitrified–warmed embryo transfer are effective for women with Kallmann syndrome.

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Acknowledgments

We received no financial support for this research.

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Authors and Affiliations

  1. Yamashita Ladies’ Clinic, 7-1-8 Isogami-dori, Chuo-ku, Kobe-shi, Hyogo, 651-0086, Japan

    Misato Shimoda, Hiroshi Iwayama, Mai Ishiyama, Ayano Nakatani & Masanori Yamashita

Authors
  1. Misato Shimoda
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  2. Hiroshi Iwayama
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  3. Mai Ishiyama
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  4. Ayano Nakatani
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  5. Masanori Yamashita
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Corresponding author

Correspondence to Misato Shimoda.

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Conflict of interest

Misato Shimoda, Hiroshi Iwayama, Mai Ishiyama, Ayano Nakatani, and Masanori Yamashita declare that they have no conflict of interest related to this report.

Human rights statements and informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and the Helsinki Declaration of 1975, as revised in 2000(5). Informed consent was obtained from the patient before inclusion in the study.

Animal studies

This article does not contain any report of studies with animal subjects performed by any of the authors.

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Shimoda, M., Iwayama, H., Ishiyama, M. et al. Successful pregnancy by vitrified–warmed embryo transfer for a woman with Kallmann syndrome. Reprod Med Biol 15, 45–49 (2016). https://doi.org/10.1007/s12522-015-0214-8

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  • DOI: https://doi.org/10.1007/s12522-015-0214-8

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