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Factors associated with a positive occupational outcome during long-term central stimulant treatment in adult ADHD

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ADHD Attention Deficit and Hyperactivity Disorders

Abstract

There is a lack of long-term studies of central stimulant (CS) treatment in adult attention-deficit/hyperactivity disorder (ADHD), and studies on functional outcomes like occupational status are rare. The current study investigated occupational status in adult ADHD patients before and after long-term CS treatment (median duration of treatment 33 months) and aimed to identify variables associated with improvement in occupational status. The collection of data was based on a naturalistic, retrospective approach using the medical records of a sample of all 117 adult ADHD patients consecutively starting treatment with CS in a specific catchment area in Norway in the period 1997 to May 2005. Most patients did not improve in occupational status during long-term CS treatment. The improved group had significantly higher baseline ADHD symptoms as measured by the general adult ADD symptom checklist (83.7 vs. 76.2, p = 0.024) and had a significantly shorter period from the first contact with adult psychiatry until they got the ADHD diagnosis (11.7 vs. 50.9 months, p = 0.001). The results indicate that long-term CS treatment itself may have limited effect on occupational status in functionally impaired and highly comorbid patients with adult ADHD. A high baseline ADHD symptom level may be related to a superior outcome in occupational status.

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References

  • Adamou M, Arif M, Asherson P, Aw TC, Bolea B, Coghill D et al (2013) Occupational issues of adults with ADHD. BMC Psychiatry 13:59

    Article  PubMed Central  PubMed  Google Scholar 

  • Airaksinen O, Brox JI, Cedraschi C, Hildebrandt J, Klaber-Moffett J, Kovacs F et al (2006) Chapter 4. European guidelines for the management of chronic nonspecific low back pain. Eur Spine J 15(Suppl 2):S192–S300

    Article  PubMed Central  PubMed  Google Scholar 

  • Amen DG (1997) General adult ADD symptom checklist. In: Clark CG (ed) ADHD throughout the lifespan. Random Clark, Las Vegas

    Google Scholar 

  • American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders (DSM-IV), 4th edn. American Psychiatric Association, Washington

  • Barkley RA, Murphy K, Fischer M (2008) Educational and occupational functioning. In: Barkley RA, Murphy K, Fischer M (eds) ADHD in adults. What science says. The Guilford Press, New York, pp 245–290

    Google Scholar 

  • Bejerot S, Ryden EM, Arlinde CM (2010) Two-year outcome of treatment with central stimulant medication in adult attention-deficit/hyperactivity disorder: a prospective study. J Clin Psychiatry 71:1590–1597

    Article  CAS  PubMed  Google Scholar 

  • Biederman J, Faraone SV, Spencer T, Wilens T, Norman D, Lapey KA et al (1993) Patterns of psychiatric comorbidity, cognition, and psychosocial functioning in adults with attention deficit hyperactivity disorder. Am J Psychiatry 150:1792–1798

    CAS  PubMed  Google Scholar 

  • Biederman J, Monuteaux MC, Spencer T, Wilens TE, Macpherson HA, Faraone SV (2008) Stimulant therapy and risk for subsequent substance use disorders in male adults with ADHD: a naturalistic controlled 10-year follow-up study. Am J Psychiatry 165:597–603

    Article  PubMed  Google Scholar 

  • Biederman J, Petty CR, Ball SW, Fried R, Doyle AE, Cohen D et al (2009) Are cognitive deficits in attention deficit/hyperactivity disorder related to the course of the disorder? A prospective controlled follow-up study of grown up boys with persistent and remitting course. Psychiatry Res 170:177–182

    Article  PubMed Central  PubMed  Google Scholar 

  • Buitelaar JK, Kooij JJ, Ramos-Quiroga JA, Dejonckheere J, Casas M, van Oene JC et al (2011) Predictors of treatment outcome in adults with ADHD treated with OROS(R) methylphenidate. Prog Neuropsychopharmacol Biol Psychiatry 35:554–560

    Article  CAS  PubMed  Google Scholar 

  • Cumyn L, French L, Hechtman L (2009) Comorbidity in adults with attention-deficit hyperactivity disorder. Can J Psychiatry 54:673–683

    PubMed  Google Scholar 

  • de Graaf R, Kessler RC, Fayyad J, ten HM, Alonso J, Angermeyer M et al (2008) The prevalence and effects of adult attention-deficit/hyperactivity disorder (ADHD) on the performance of workers: results from the WHO World Mental Health Survey Initiative. Occup Environ Med 65:835–842

    Article  PubMed Central  PubMed  Google Scholar 

  • De Ridder KA, Pape K, Johnsen R, Westin S, Holmen TL, Bjorngaard JH (2012) School dropout: a major public health challenge: a 10-year prospective study on medical and non-medical social insurance benefits in young adulthood, the Young-HUNT 1 Study (Norway). J Epidemiol Community Health 66:995–1000

    Article  PubMed  Google Scholar 

  • Derogatis LR, Lipman RS, Rickels K, Uhlenhuth EH, Covi L (1974) The Hopkins Symptom Checklist (HSCL): a self-report symptom inventory. Behav Sci 19:1–15

    Article  CAS  PubMed  Google Scholar 

  • Faraone SV, Glatt SJ (2010) A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes. J Clin Psychiatry 71:754–763

    Article  PubMed  Google Scholar 

  • Fischer M, Barkley RA, Smallish L, Fletcher K (2002) Young adult follow-up of hyperactive children: self-reported psychiatric disorders, comorbidity, and the role of childhood conduct problems and teen CD. J Abnorm Child Psychol 30:463–475

    Article  PubMed  Google Scholar 

  • Fredriksen M, Halmoy A, Faraone SV, Haavik J (2013) Long-term efficacy and safety of treatment with stimulants and atomoxetine in adult ADHD: a review of controlled and naturalistic studies. Eur Neuropsychopharmacol 23(6):508–527

    Google Scholar 

  • Ginsberg L, Katic A, Adeyi B, Dirks B, Babcock T, Lasser R et al (2011) Long-term treatment outcomes with lisdexamfetamine dimesylate for adults with attention-deficit/hyperactivity disorder stratified by baseline severity. Curr Med Res Opin 27:1097–1107

    Article  CAS  PubMed  Google Scholar 

  • Gjervan B, Torgersen T, Nordahl HM, Rasmussen K (2012) Functional impairment and occupational outcome in adults with ADHD. J Atten Disord 16:544–552

    Article  PubMed  Google Scholar 

  • Goodman DW (2013) Sustained treatment effect in attention-deficit/hyperactivity disorder: focus on long-term placebo-controlled randomized maintenance withdrawal and open-label studies. Ther Clin Risk Manag 9:121–130

    Article  PubMed Central  PubMed  Google Scholar 

  • Halmoy A, Fasmer OB, Gillberg C, Haavik J (2009) Occupational outcome in adult ADHD: impact of symptom profile, comorbid psychiatric problems, and treatment: a cross-sectional study of 414 clinically diagnosed adult ADHD patients. J Atten Disord 13:175–187

    Article  PubMed  Google Scholar 

  • Hechtman L, Weiss G, Perlman T (1984) Young adult outcome of hyperactive children who received long-term stimulant treatment. J Am Acad Child Psychiatry 23:261–269

    Article  CAS  PubMed  Google Scholar 

  • Jensen PS, Arnold LE, Swanson JM, Vitiello B, Abikoff HB, Greenhill LL et al (2007) 3-year follow-up of the NIMH MTA study. J Am Acad Child Adolesc Psychiatry 46:989–1002

    Article  PubMed  Google Scholar 

  • Koesters M, Becker T, Kilian R, Fegert JM, Weinmann S (2009) Limits of meta-analysis: methylphenidate in the treatment of adult attention-deficit hyperactivity disorder. J Psychopharmacol 23:733–744

    Article  CAS  PubMed  Google Scholar 

  • Krokstad S, Johnsen R, Westin S (2002) Social determinants of disability pension: a 10-year follow-up of 62,000 people in a Norwegian county population. Int J Epidemiol 31:1183–1191

    Article  PubMed  Google Scholar 

  • Kupper T, Haavik J, Drexler H, Ramos-Quiroga JA, Wermelskirchen D, Prutz C et al (2012) The negative impact of attention-deficit/hyperactivity disorder on occupational health in adults and adolescents. Int Arch Occup Environ Health 85:837–847

    Article  PubMed  Google Scholar 

  • Lensing MB, Zeiner P, Sandvik L, Opjordsmoen S (2013) Four-year outcome in psychopharmacologically treated adults with attention-deficit/hyperactivity disorder: a questionnaire survey. J Clin Psychiatry 74:e87–e93

    Article  PubMed  Google Scholar 

  • Mannuzza S, Klein RG, Bessler A, Malloy P, LaPadula M (1993) Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status. Arch Gen Psychiatry 50:565–576

    Article  CAS  PubMed  Google Scholar 

  • Marwaha S, Johnson S (2004) Schizophrenia and employment—a review. Soc Psychiatry Psychiatr Epidemiol 39:337–349

    Article  PubMed  Google Scholar 

  • Molina BS, Flory K, Hinshaw SP, Greiner AR, Arnold LE, Swanson JM et al (2007) Delinquent behavior and emerging substance use in the MTA at 36 months: prevalence, course, and treatment effects. J Am Acad Child Adolesc Psychiatry 46:1028–1040

    Article  PubMed  Google Scholar 

  • Murphy K, Barkley RA (1996) Attention deficit hyperactivity disorder adults: comorbidities and adaptive impairments. Compr Psychiatry 37:393–401

    Article  CAS  PubMed  Google Scholar 

  • OECD (2012) Employment rate % of working age population. OECDiLibrary July 11. doi:10.1787/20752342-table4

  • Peterson K, McDonagh MS, Fu R (2008) Comparative benefits and harms of competing medications for adults with attention-deficit hyperactivity disorder: a systematic review and indirect comparison meta-analysis. Psychopharmacology 197:1–11

    Article  CAS  PubMed  Google Scholar 

  • Rasmussen K, Levander S (2009) Untreated ADHD in adults: are there sex differences in symptoms, comorbidity, and impairment? J Atten Disord 12:353–360

    Article  PubMed  Google Scholar 

  • Reimherr FW, Williams ED, Strong RE, Mestas R, Soni P, Marchant BK (2007) A double-blind, placebo-controlled, crossover study of osmotic release oral system methylphenidate in adults with ADHD with assessment of oppositional and emotional dimensions of the disorder. J Clin Psychiatry 68:93–101

    Article  CAS  PubMed  Google Scholar 

  • Safren SA, Sprich SE, Cooper-Vince C, Knouse LE, Lerner JA (2010) Life impairments in adults with medication-treated ADHD. J Atten Disord 13:524–531

    Article  PubMed Central  PubMed  Google Scholar 

  • Satterfield JH, Faller KJ, Crinella FM, Schell AM, Swanson JM, Homer LD (2007) A 30-year prospective follow-up study of hyperactive boys with conduct problems: adult criminality. J Am Acad Child Adolesc Psychiatry 46:601–610

    Article  PubMed  Google Scholar 

  • Shaw M, Hodgkins P, Caci H, Young S, Kahle J, Woods AG et al (2012) A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment. BMC Med 10:99

    Article  PubMed Central  PubMed  Google Scholar 

  • Sobanski E, Bruggemann D, Alm B, Kern S, Deschner M, Schubert T et al (2007) Psychiatric comorbidity and functional impairment in a clinically referred sample of adults with attention-deficit/hyperactivity disorder (ADHD). Eur Arch Psychiatry Clin Neurosci 257:371–377

    Article  PubMed  Google Scholar 

  • Tandberg M, Ueland T, Andreassen OA, Sundet K, Melle I (2012) Factors associated with occupational and academic status in patients with first-episode psychosis with a particular focus on neurocognition. Soc Psychiatry Psychiatr Epidemiol 47:1763–1773

    Article  PubMed  Google Scholar 

  • Torgersen T, Gjervan B, Rasmussen K (2008) Treatment of adult ADHD: is current knowledge useful to clinicians? Neuropsychiatr Dis Treat 4:177–186

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Torgersen T, Gjervan B, Nordahl HM, Rasmussen K (2012) Predictive factors for more than 3 years’ duration of central stimulant treatment in adult attention-deficit/hyperactivity disorder: a retrospective, naturalistic study. J Clin Psychopharmacol 32:645–652

    Article  PubMed  Google Scholar 

  • Torgersen T, Gjervan B, Rasmussen K, Vaaler A, Nordahl HM (2013) Prevalence of comorbid substance use disorder during long-term central stimulant treatment in adult ADHD. Atten Defic Hyperact Disord 5:59–67

    Article  PubMed  Google Scholar 

  • Trivedi MH, Morris DW, Wisniewski SR, Lesser I, Nierenberg AA, Daly E et al (2013) Increase in work productivity of depressed individuals with improvement in depressive symptom severity. Am J Psychiatry 170:633–641

    Article  PubMed  Google Scholar 

  • Waddell G, Burton AK (2005) Concepts of rehabilitation for the management of low back pain. Best Pract Res Clin Rheumatol 19:655–670

    Article  PubMed  Google Scholar 

  • Weiss G (1985) Hyperactivity. Overview and new directions. Psychiatr Clin N Am 8:737–753

    CAS  Google Scholar 

  • Weiss M, Hechtman L (2006) A randomized double-blind trial of paroxetine and/or dextroamphetamine and problem-focused therapy for attention-deficit/hyperactivity disorder in adults. J Clin Psychiatry 67:611–619

    Article  CAS  PubMed  Google Scholar 

  • Wender PH, Reimherr FW, Marchant BK, Sanford ME, Czajkowski LA, Tomb DA (2011) A one year trial of methylphenidate in the treatment of ADHD. J Atten Disord 15:36–45

    Article  PubMed  Google Scholar 

  • Wigal T, Brams M, Gasior M, Gao J, Squires L, Giblin J (2010) Randomized, double-blind, placebo-controlled, crossover study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder: novel findings using a simulated adult workplace environment design. Behav Brain Funct 6:34

    Article  PubMed Central  PubMed  Google Scholar 

  • Wilens TE (2003) Does the medicating ADHD increase or decrease the risk for later substance abuse? Rev Br Psiquiatr 25:127–128

    Article  Google Scholar 

  • Wilens TE, Biederman J, Faraone SV, Martelon M, Westerberg D, Spencer TJ (2009) Presenting ADHD symptoms, subtypes, and comorbid disorders in clinically referred adults with ADHD. J Clin Psychiatry 70:1557–1562

    Article  PubMed Central  PubMed  Google Scholar 

  • World Health Organization (1992) International classification of diseases, 10th revision. Criteria for research, Geneva

    Google Scholar 

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Correspondence to Terje Torgersen.

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Torgersen, T., Krokstad, S. & Vaaler, A.E. Factors associated with a positive occupational outcome during long-term central stimulant treatment in adult ADHD. ADHD Atten Def Hyp Disord 6, 281–290 (2014). https://doi.org/10.1007/s12402-014-0135-0

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