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Molecular probes for cardiovascular imaging

  • Molecular Imaging Corner
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

Molecular probes provide imaging signal and contrast for the visualization, characterization, and measurement of biological processes at the molecular level. These probes can be designed to target the cell or tissue of interest and must be retained at the imaging site until they can be detected by the appropriate imaging modality. In this article, we will discuss the basic design of molecular probes, differences among the various types of probes, and general strategies for their evaluation of cardiovascular disease.

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Abbreviations

CT:

Computed tomography

18F-FDG:

18 F-Fluorodeoxyglucose

HMPAO:

Hexamethylpropyleneamine oxime

HSV-TK:

Herpes simplex virus type I thymidine kinase

MR:

Magnetic resonance

PET:

Positron emission tomography

SPECT:

Single photon emission tomography

SPIO:

Superparamagnetic iron oxide particles

99mTc:

Technetium 99 M

VCAM-1:

Vascular adhesion molecule-1

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Acknowledgements

We would like to thank Ian Chen, MD, PhD and Joseph Wu, MD, PhD for their assistance in editing this manuscript. We would like to thank Amy Morris for her contribution to the figures. We would also like to thank the Stanford Cardiovascular Institute, American Heart Association, and the Veterans Affairs for their support.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, Department of Medicine, Stanford University, 3801 Miranda Ave, Stanford, CA, 94304, USA

    Grace Liang BS & Patricia K. Nguyen MD

  2. Cardiology Section, VA Palo Alto Health Care System, Palo Alto, CA, USA

    Grace Liang BS & Patricia K. Nguyen MD

Authors
  1. Grace Liang BS
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  2. Patricia K. Nguyen MD
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Corresponding author

Correspondence to Patricia K. Nguyen MD.

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Liang, G., Nguyen, P.K. Molecular probes for cardiovascular imaging. J. Nucl. Cardiol. 23, 783–789 (2016). https://doi.org/10.1007/s12350-016-0501-8

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  • DOI: https://doi.org/10.1007/s12350-016-0501-8

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