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Pallidal Activity in Cervical Dystonia with and Without Head Tremor

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Abstract

The relationship between two common movement disorders, dystonia and tremor, is controversial. Both deficits have correlates in the network that includes connections between the cerebellum and the basal ganglia. In order to assess the physiological relationship between tremor and dystonia, we measured the activity of 727 pallidal single-neurons during deep brain stimulation surgery in patients with cervical dystonia without head oscillations, cervical dystonia plus jerky oscillations, and cervical dystonia with sinusoidal oscillations. Cluster analyses of spike-train recordings allowed classification of the pallidal activity into burst, pause, and tonic. Burst neurons were more common, and number of spikes within spike and inter-burst intervals was shorter in pure dystonia and jerky oscillation groups compared to the sinusoidal oscillation group. Pause neurons were more common and irregular in pure tremor group compared to pure dystonia and jerky oscillation groups. There was bihemispheric asymmetry in spontaneous firing discharge in pure dystonia and jerky oscillation groups, but not in sinusoidal oscillation group. These results demonstrate that the physiology of pallidal neurons in patients with pure cervical dystonia is similar to those who have cervical dystonia combined with jerky oscillations, but different from those who have cervical dystonia combined with sinusoidal oscillations. These results imply distinct mechanistic underpinnings for different types of head oscillations in cervical dystonia.

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Funding

The study was funded by the Russian Science Foundation project 18-15-00009 (Sedov) for data collection and analysis; The Russian Foundation for Basic Research project 18-315-00202 and 20-015-00438 (Semenova) for estimation of head oscillation; The Career Development Grant from the American Academy of Neurology (Shaikh); George C. Cotzias Memorial Fellowship from American Parkinson’s Disease Association (Shaikh), Network Models in Dystonia grant from the Dystonia Medical Research Foundation (Shaikh), philanthropic funds to the department of neurology at University Hospitals (Shaikh). NIH U54 TR001456 (Jinnah).

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Authors and Affiliations

  1. Semenov Institute of chemical physics, Russian Academy of Sciences, Moscow, Russia

    Alexey Sedov, Svetlana Usova & Ulia Semenova

  2. Moscow Institute of physics and technology, Moscow, Dolgoprudny, Russia

    Alexey Sedov

  3. N .N. Burdenko National Scientific and Practical Center for Neurosurgery, Moscow, Russia

    Anna Gamaleya & Alexey Tomskiy

  4. Departments of Neurology and Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA

    Sinem B. Beylergil & Aasef G. Shaikh

  5. Department of Neurology, Pediatrics, and Genetics, Emory University, Atlanta, GA, USA

    H.A. Jinnah

  6. Neurological Institute, University Hospitals, Cleveland, OH, USA

    Aasef G. Shaikh

  7. Neurology Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA

    Aasef G. Shaikh

  8. Department of Neurology, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA

    Aasef G. Shaikh

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  1. Alexey Sedov
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  2. Svetlana Usova
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Sedov, A., Usova, S., Semenova, U. et al. Pallidal Activity in Cervical Dystonia with and Without Head Tremor. Cerebellum 19, 409–418 (2020). https://doi.org/10.1007/s12311-020-01119-5

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