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High Sensitivity C Reactive Protein: An Adjunct Diagnosis in Ruling Out Pediatric Tuberculosis

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Abstract

The utility of C-reactive protein (CRP) as a marker of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 clinically diagnosed (clinical findings and radiography and/or contact history and/or Mantoux test) or microbiologically confirmed (smear and/or culture and/or Cartridge based Nucleic Acid Amplification test positive) pediatric tuberculosis cases ≤ 12 years. hs CRP levels were estimated in the cases and healthy controls using ELISA. Median levels of serum hs CRP were significantly higher in pediatric tuberculosis cases (25 mg/l) as compared to controls (0.530 mg/l). No significant correlation was found with age, gender, site of tuberculosis or presence of dissemination. Lower levels were found with palpable lymphadenopathy. Levels were not significantly different between microbiologically confirmed cases and those who were negative by one or more of the microbiological tests of staining, culture and cartridge based nucleic acid amplification test. hs CRP can be used in diagnostic algorithms of pediatric tuberculosis to rule out tuberculosis. Further studies could help in determining the prognostic and therapeutic response of hs CRP among children leading to better management.

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Authors and Affiliations

  1. Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, 110095, India

    Bineeta Kashyap, Neha Gupta & N. P. Singh

  2. Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, 110095, India

    Pooja Dewan

  3. DOTS Center, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, 110095, India

    Puneeta Hyanki

  4. Flat no. C-402, Vimal CGHS LTD, Plot-3, Sector-12, Dwarka, New Delhi, Delhi, 110078, India

    Bineeta Kashyap

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  1. Bineeta Kashyap
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  2. Neha Gupta
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  4. Puneeta Hyanki
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  5. N. P. Singh
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Correspondence to Bineeta Kashyap.

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Kashyap, B., Gupta, N., Dewan, P. et al. High Sensitivity C Reactive Protein: An Adjunct Diagnosis in Ruling Out Pediatric Tuberculosis. Ind J Clin Biochem 35, 211–217 (2020). https://doi.org/10.1007/s12291-018-0806-2

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  • DOI: https://doi.org/10.1007/s12291-018-0806-2

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