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Incidence and Analysis of 7 Years Adverse Transfusion Reaction: A Retrospective Analysis

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Safe blood transfusion is the primary need of all the health care delivery system. Though with the advances of transfusion medicine, the incidences of transfusion risk is gradually reduced, but the adverse transfusion reaction (ATR) of non hemolytic type still prevails. The purpose of this study was to estimate the incidence and pattern of transfusion-related adverse events at our centre. The present retrospective observational study was conducted in the Department of Transfusion Medicine from April 2011 to April 2018, at a multi-organ transplant centre in South India. All the Adverse transfusion reactions were investigated in detail in the blood bank for the clerical errors, immunohematology workup and classified according to their nature with imputability assessment. A total of 140 ATR were reported out of 100,569 blood components distributed during the study period. After the analysis and workup of the reported reactions, majority of the reactions were observed in males (71%, n = 99). Most common symptom presented was Itching/Rashes in 43.6% (n = 61) ATR. Allergic reactions (51.4%, n = 72), were the most commonly encountered ATR followed by FNHTR (25.7%, n = 36). FFP transfusions (0.2%) contributed to the majority of the reactions followed by Red cell transfusion (0.15%). ATR were observed maximum in Hepato-biliary disease and liver transplantation patients (62%) followed by oncology patients (15%). The overall incidence of ATR in our study is 0.14% which is comparatively low compared to other studies due to well established hemovigilance systems. Adoption of more equipped methods & sensitive technology in various areas of blood banking will help to bring down the unwanted adverse transfusion reactions.

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References

  1. Andreu G, Morel P, Forestier F, Debeir J, Rebibo D, Janvier G et al (2002) Hemovigilance network in France: organization and analysis of immediate transfusion incident reports from 1994 to 1998. Transfusion 42:1356–1364

    Article  Google Scholar 

  2. Robillard P, Karl Itaj N (2002) Incidence of adverse transfusion reactions in the Quebec Hemovigilance System. Vox Sang 83:120

    Google Scholar 

  3. Mazzezi CA, Popovsky MA, Kopko PM (2014) Non infectious complications of blood transfusion. In: Fung MK (ed) Technical manual, 18th edn. American Association of Blood Bank, Bethesda, pp 685–695

    Google Scholar 

  4. Philip J, Pawar A, Chatterjee T, Malhi RS, Biswas AK, Dimri U (2015) Non infectious complications related to blood transfusion: an 11 year retrospective analysis in a tertiary care hospital. Indian J Hematol Blood Transfus 32:292–298

    Article  Google Scholar 

  5. Fumiya H (2013) Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment. Br J Haematol 160(4):434–444

    Article  Google Scholar 

  6. Savage WJ, Tobian AA, Savage JH, Hamilton RG, Ness PM (2011) A topic predisposition of recipients in allergic transfusion reactions to apheresis platelets. Transfusion 51:2337–2342

    Article  Google Scholar 

  7. Domen RE, Hoeltge GA (2003) Allergic transfusion reactions: an evaluation of 273 consecutive reactions. Arch Pathol Lab Med 127:316–320

    PubMed  Google Scholar 

  8. Sandler SG, Mallory D, Malamut D, Eckrich R (1995) IgA anaphylactic transfusion reactions. Trans Med Rev 9(1):1–8

    Article  CAS  Google Scholar 

  9. Matsuyama N, Hirayama F, Wakamoto S, Yasui K, Furuta RA, Kimura T et al (2009) Application of the basophil activation test in the analysis of allergic transfusion reactions. Transfus Med 19:274–277

    Article  CAS  Google Scholar 

  10. Hirayama F (2010) Recent advances in laboratory assays for nonhemolytic transfusion reactions. Transfusion 50:252–263

    Article  CAS  Google Scholar 

  11. Sandler SG, Vassallo RR (2011) Anaphylactic transfusion reactions. Transfusion 51:2265–2266

    Article  Google Scholar 

  12. Burks AW, Sampson HA, Buckley RH (1986) Anaphylactic reactions after gamma globulin administration in patients with hypogammaglobulinemia. Detection of IgE antibodies to IgA. N Engl J Med 314:560–564

    Article  CAS  Google Scholar 

  13. Harper JL, Gill JC, Hopp RJ, Evans J, Haire WD (1995) Induction of immune tolerance in a 7-year-old hemophiliac with an anaphylactoid inhibitor. Thromb Haemost 74:1039–1041

    Article  CAS  Google Scholar 

  14. Kumar P, Thapliyal R, Coshic P, Chatterjee K (2013) Retrospective evaluation of adverse transfusion reactions following blood product transfusion from a tertiary care hospital: a preliminary step towards hemovigilance. Asian J Transfus Sci 7:109–115

    Article  Google Scholar 

  15. Bhattacharya P, Marwaha N, Dhawan HK, Roy P, Sharma RR (2011) Transfusion-related adverse events at the tertiary care center in North India: an institutional hemovigilance effort. Asian J Transfus Sci 5:164–170

    Article  Google Scholar 

  16. Sharma DK, Datta S, Gupta A (2015) Study of acute transfusion reactions in a teaching hospital of Sikkim: a hemovigilance initiative. Indian J Pharmacol 47:370–374

    Article  CAS  Google Scholar 

  17. Bassi R, Aggarwal S, Bhardwaj K, Thakur KK (2017) Patterns of adverse transfusion reactions in a tertiary care centre of North India: a step towards hemovigilance. Indian J Hematol Blood Transfus 33:248–253

    Article  Google Scholar 

  18. Pahuja S, Puri V, Mahajan G, Gupta P, Jain M (2017) Reporting adverse transfusion reactions: a retrospective study from tertiary care hospital from New Delhi, India. Asian J Transfus Sci 11:6–12

    Article  Google Scholar 

  19. Hendrickson JE, Roubinian NH, Chowdhury D, Brambilla D, Murphy EL, Wu Y et al (2016) Incidence of transfusion reactions: a multi-center study utilizing systematic active surveillance and expert adjudication. Transfusion 56:2587–2596

    Article  Google Scholar 

  20. Blumberg N, Heal JM, Gettings KF, Phipps RP, Masel D, Refaai MA et al (2010) An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions. Transfusion 50:2738–2744

    Article  Google Scholar 

  21. Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, The National Heart Lung and Blood Institute Working Group on TRALI et al (2005) Transfusion-related acute lung injury: definition and review. Crit Care Med 33:721–726

    Article  Google Scholar 

  22. Goldman M, Webert KE, Arnold DM, Freedman J, Hannon J, Blajchman MA (2005) Proceedings of a consensus conference: towards and understanding of TRALI 2005. Transfus Med Rev 19:2–31

    Article  Google Scholar 

  23. Triulzi DJ (2009) Transfusion-related acute lung injury: current concepts for the clinician. Anesth Analg 108:770–776

    Article  Google Scholar 

  24. Erwin S (2008) Hemolytic transfusion reactions. Transfus Med Hemother 35:346–353

    Article  Google Scholar 

  25. Beauregard P, Blajchman MA (1994) Hemolytic and pseudo-hemolytic transfusion reactions: an overview of the hemolytic transfusion reactions and the clinical conditions that mimic them. Transfus Med Rev 8(3):184–199

    Article  CAS  Google Scholar 

  26. Payandeh M, Zare ME, Kansestani AN et al (2013) Descriptions of acute transfusion reactions in the teaching Hospitals of Kermanshah University of Medical Sciences, Iran. Int J Hematol Oncol Stem cell Res 7:11–16

    PubMed  PubMed Central  Google Scholar 

  27. Mafirakureva N, Khoza S, Mvere DA, Chitiyo ME, Postma MJ, Van Hulst M (2014) Incidence and pattern of 12 years of reported transfusion adverse events in Zimbabwe: a retrospective analysis. Blood Transfus. 12:362–367

    PubMed  PubMed Central  Google Scholar 

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Author notes

  1. Suryatapa Saha

    Present address: Department of Transfusion Medicine, Apollo Gleneagles Hospital, Calcutta, India

  2. Deepti Sachan

    Present address: Department of Transfusion Medicine, Dr. Rela Institute and Medical Centre, No. 7, CLC Works Road, Chromepet, Chennai, Tamil Nadu, 600044, India

Authors and Affiliations

  1. Department of Transfusion Medicine, Gleneagles Global Health City, Chennai, 600100, India

    Suryatapa Saha, Deepthi Krishna, Raghuram Prasath & Deepti Sachan

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  1. Suryatapa Saha
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  2. Deepthi Krishna
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  3. Raghuram Prasath
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  4. Deepti Sachan
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Correspondence to Deepti Sachan.

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All procedures were done in accordance of ethical standards. Informed Consent was taken from the patient before blood transfusion.

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Saha, S., Krishna, D., Prasath, R. et al. Incidence and Analysis of 7 Years Adverse Transfusion Reaction: A Retrospective Analysis. Indian J Hematol Blood Transfus 36, 149–155 (2020). https://doi.org/10.1007/s12288-019-01174-x

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  • DOI: https://doi.org/10.1007/s12288-019-01174-x

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