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Fresh Frozen Plasma and Platelet Transfusion Practices in Neonatal Intensive Care Unit of a Tertiary Care Hospital

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Abstract

Blood transfusion is an indispensable part of modern medical and surgical practices. More than 35% of critically ill patients receive transfusion of blood components during their intensive care unit stay. The aim of study is to obtain an information regarding the relationship of platelet concentrate (PC) and fresh frozen plasma (FFP) transfusion on clinical outcome of neonates admitted in neonatal ICU (NICU). This prospective cohort study was conducted from 1st November 2011 to 30th April 2013. The clinical history, blood component details and laboratory parameters were evaluated with clinical outcome. The neonates requiring PC and FFP transfusion were followed up in blood bank for laboratory parameters. Clinical parameters were noted from case file. During the study period, 291 neonates were admitted in NICU. 2 neonates had congenital malformations and thus, were excluded from the study. Of the remaining 289 neonates, 49 neonates received transfusion of platelets and/or FFP. The combined mean donor exposure for all components was found to be 1.48. The mean volume of PC and FFP transfused was 20 ml and 30 ml respectively. The mean pre- and post-transfusion platelet count was 34,000 µl and 42,000 µl respectively. The mean pre- and post-transfusion INR was 2.37 and 1.53 respectively. There was a significant increase in platelet count and decrease in INR in transfused neonates. However, no clinical benefit of PC and FFP transfusion seen on bleeding. Transfusion of PC and FFP has significant effect on laboratory parameters as compared to clinical parameter.

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References

  1. Vincent JL, Baron JF, Reinhart K, Gattinoni L, Thijs L, Webb A et al (2002) Anemia and blood transfusion in critically ill patients. JAMA 288:1499–1507

    Article  Google Scholar 

  2. Hensch LA, Indrikovs AJ, Shattuck KE (2015) Transfusion in extremely low-birth-weight premature neonates: current practice trends, risks, and early interventions to decrease the need for transfusion. NeoReviews 16:e287–e296

    Article  Google Scholar 

  3. Christensen RD, Henry E, Wiedmeier SE, Stoddard RA, Sola-Visner MC, Lambert DK et al (2006) Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system. J Perinatol Off J Calif Perinat Assoc 26:348–353

    CAS  Google Scholar 

  4. Josephson CD (2014) Neonatal and pediatric transfusion practice. In: Roback JD, Combs MR, Grossman BJ, Hillyer CD (eds) AABB technical manual, 18th edn. AABB Press, Bethesda, pp 580–583

    Google Scholar 

  5. von Lindern JS, van den Bruele T, Lopriore E, Walther FJ (2011) Thrombocytopenia in neonates and the risk of intraventricular hemorrhage: a retrospective cohort study. BMC Pediatr 11:16

    Article  Google Scholar 

  6. Motta M, Del Vecchio A, Chirico G (2015) Fresh frozen plasma administration in the neonatal intensive care unit: evidence-based guidelines. Clin Perinatol 42:639–650

    Article  Google Scholar 

  7. Veljkovic D (2011) Use fresh-frozen plasma in newborns, older infants and adolescents on the outcome of bleeding. ISBT Sci Ser 6:198–205

    Article  Google Scholar 

  8. Murray NA, Howarth LJ, McCloy MP, Letsky EA, Roberts IA (2002) Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients. Transfus Med 12:35–41

    Article  CAS  Google Scholar 

  9. Sparger KA, Assmann SF, Granger S, Winston A, Christensen RD, Widness JA et al (2016) Platelet transfusion practices among very-low-birth-weight infants. JAMA Pediatr 170:687–694

    Article  Google Scholar 

  10. Stanworth SJ, Clarke P, Watts T, Ballard S, Coo L, Morris T et al (2009) Prospective, observational study of outcomes in neonates with severe thrombocytopenia. Pediatrics 124:e826–e834

    Article  Google Scholar 

  11. Carra R, Kelly AM, Williamson LM (2015) Neonatal thrombocytopenia and platelet transfusion—a UK perspective. Neonatology 107:1–7

    Article  Google Scholar 

  12. Josephson CD, Su LL, Christensen RD, Hillyer CD, Castillejo MI, Emory MR et al (2009) Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey. Pediatrics 123:278–285

    Article  Google Scholar 

  13. Kenton AB, Hegemier S, Smith B, O’Donovan DJ, Brandt ML, Cass DL et al (2005) Platelet transfusions in infants with necrotizing enterocolitis do not lower mortality but may increase morbidity. J Perinatol 25:173–177

    Article  Google Scholar 

  14. Contreras M, Ala FA, Greaves M, Jones J, Levin M, Machin SJ et al (1992) Guidelines for the use of fresh frozen plasma. British committee for standards in haematology, working party of the blood transfusion task force. Transfus Med 2:57–63

    Article  CAS  Google Scholar 

  15. Northern Neonatal Nursing Initiative Trial Group (1996) Randomised trial of prophylactic early fresh-frozen plasma or gelatin or glucose in preterm babies: outcome at 2 years. Lancet 348:229–232

    Article  Google Scholar 

  16. Motta M, Del Vecchio A, Perrone B, Ghirardello S, Radicioni M (2014) Fresh frozen plasma use in the NICU: a prospective, observational, multicentred study. Arch Dis Child Fetal Neonatal 99:303–308

    Article  Google Scholar 

  17. Altuntas N, Yenicesu I, Beken S, Kulali F, Burcu Belen F, Hirfanoglu IM et al (2012) Clinical use of fresh-frozen plasma in neonatal intensive care unit. Transfus Apher Sci 47:91–94

    Article  Google Scholar 

  18. Stanworth SJ, Grant-Casey J, Lowe D, Laffan M, New H, Murphy MF et al (2011) The use of fresh-frozen plasma in England: high levels of inappropriate use in adults and children. Transfusion. 51:62–70

    Article  Google Scholar 

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Transfusion Medicine, AIIMS, New Delhi, India

    Kanchan Dogra

  2. Department of Transfusion Medicine, GMCH, Sector-32, Chandigarh, India

    Gagandeep Kaur

  3. Tata Medical Center, Kolkota, India

    Sabita Basu

  4. Department of Paediatrics, GMCH, Sector-32, Chandigarh, India

    Deepak Chawla

Authors
  1. Kanchan Dogra
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  2. Gagandeep Kaur
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  3. Sabita Basu
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  4. Deepak Chawla
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Contributions

KD, GK wrote the manuscript, KD collected and analysed the data, SB, DC revised the article critically for important intellectual content, DC also took care of the patients. All authors have read and approved the manuscript being submitted, and agree to its submission to this journal.

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Correspondence to Gagandeep Kaur.

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Dogra, K., Kaur, G., Basu, S. et al. Fresh Frozen Plasma and Platelet Transfusion Practices in Neonatal Intensive Care Unit of a Tertiary Care Hospital. Indian J Hematol Blood Transfus 36, 141–148 (2020). https://doi.org/10.1007/s12288-019-01164-z

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  • DOI: https://doi.org/10.1007/s12288-019-01164-z

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