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Down Syndrome with Different Hematological Manifestations: A Short Series of 3 Cases with Review of Literature

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Abstract

Children with Down syndrome (DS) present with a spectrum of hematolymphoid malignancies ranging from transient myeloproliferative disorder (TMD) which regress spontaneously to frank acute leukemia of both myeloid and lymphoid lineage. Here we present a series of three cases with different manifestation in DS. Three cases of DS presented with TMD, acute myeloid leukemia (AML–M2) and acute megakaryoblastic leukemia (AMKL), respectively. This case series displays the spectrum of hematological manifestations in children with DS. Although TMD and AMKL are strongly associated with DS, other AML subtypes can also be seen in such patients.

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References

  1. Rabin KR, Whitlock JA (2009) Malignancy in children with trisomy 21. Oncologist 14:164–173

    Article  PubMed  Google Scholar 

  2. Massey GV, Zipursky A, Chang MN, Doyle JJ, Nasim S, Taub JW et al (2006) A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children Oncology Group (COG) study POG-9481. Blood 107:4606–4613

    Article  PubMed  CAS  Google Scholar 

  3. Baumann I, Niemeyer CM, Brunning RD, Arber DA, Porwit A (2008) Myeloid proliferations related to Down syndrome. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. IARC, Lyon, pp 142–144

    Google Scholar 

  4. Roizen NJ, Patterson D (2003) Down’s syndrome. Lancet 361:1281–1289

    Article  PubMed  Google Scholar 

  5. Zipursky A, Brown EJ, Christensen H, Doyle J (1999) Transient myeloproliferative disorder (transient leukemia) and hematologic manifestations of Down syndrome. Clin Lab Med 19:157–167

    PubMed  CAS  Google Scholar 

  6. Zipursky A, Brown E, Christensen H, Sutherland R, Doyle J (1997) Leukemia and/or myeloproliferative syndrome in neonates with Down syndrome. Semin Perinatol 21:97–101

    Article  PubMed  CAS  Google Scholar 

  7. Bhatt S, Schreck R, Graham JM et al (1995) Transient leukemia with trisomy 21. Am J Med Genet 58:310–314

    Article  PubMed  CAS  Google Scholar 

  8. Aier M, Zadeng T, Basu D, Biswal N, Nalini P (2002) Congenital leukemia in Down syndrome–a case report. Indian J Pathol Microbiol 45:355–357

    PubMed  Google Scholar 

  9. Homans AC, Verissimo AM, Vlacha V (1993) Transient abnormal myelopoiesis of infancy associated with trisomy 21. Am J Pediatr Hematol Oncol 15:392–397

    PubMed  CAS  Google Scholar 

  10. Karandikar NJ, Aquino DB, McKenna RW, Kroft SH (2001) Transient myeloproliferative disorder and acute myeloid leukemia in Down syndrome. Am J Clin Pathol 116:204–210

    Article  PubMed  CAS  Google Scholar 

  11. Ahmed M, Sternberg A, Hall G, Thomas A, Smith O, O’Marcaigh A et al (2004) Natural history of GATA 1 mutations in Down syndrome. Blood 103:2480–2489

    Article  PubMed  CAS  Google Scholar 

  12. Ge Y, Stout ML, Tatman DA, Jensen TL, Buck S, Thomas RL (2005) GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia. J Natl Cancer Inst 97:226–231

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, JIPMER, Puducherry, 605 006, India

    Prabhu Manivannan, Priavadhana Rajan Prasaad, Rakhee Kar & Debdatta Basu

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  1. Prabhu Manivannan
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  2. Priavadhana Rajan Prasaad
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  3. Rakhee Kar
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  4. Debdatta Basu
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Correspondence to Rakhee Kar.

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Manivannan, P., Prasaad, P.R., Kar, R. et al. Down Syndrome with Different Hematological Manifestations: A Short Series of 3 Cases with Review of Literature. Indian J Hematol Blood Transfus 29, 31–34 (2013). https://doi.org/10.1007/s12288-011-0134-7

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  • DOI: https://doi.org/10.1007/s12288-011-0134-7

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