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Cell-based drug delivery systems for biomedical applications

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Abstract

Spurred by numerous achievements in nanoscience and nanotechnology, the evolution of nanoparticulate drug delivery systems (nano-DDSs) is in its rapid growth period and attracting considerable attention due to their unique advantages in biomedical applications. Natural particulates ranging from mammalian cells to bacteria possess their own distinctive delivery processes and mechanisms, which inspires more design and development of cell-based DDSs by integrating the innate functions of cells with the nanoscale characteristics of nanoparticles. In this review article, we focus on the recent advances in cell-based DDSs for site-specific delivery of therapeutics and enhanced treatment of diseases. The promise and perils of cell-based DDSs are also discussed.

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Acknowledges

This work was supported by the National Natural Science Foundation of China (No. 81673381), the Natural Science Foundation of Jiangsu Province of China for Distinguished Young Scholars (No. BK20150029), the Program for Jiangsu Province Innovative Research Talents, and the Program for Jiangsu Province Innovative Research Team.

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  1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, China

    Teng Li, He Dong, Can Zhang & Ran Mo

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  1. Teng Li
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  2. He Dong
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Correspondence to Can Zhang or Ran Mo.

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Li, T., Dong, H., Zhang, C. et al. Cell-based drug delivery systems for biomedical applications. Nano Res. 11, 5240–5257 (2018). https://doi.org/10.1007/s12274-018-2179-5

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