Abstract
Deafness is the prevailing sensory impairment among humans, impacting every aspect of one's existence. Half of congenital deafness cases are attributed to genetic factors. Studies have shown that Luzp2 is expressed in hair cells (HCs) and supporting cells of the inner ear, but its specific role in hearing remains unclear. To determine the importance of Luzp2 in auditory function, we generated mice deficient in Luzp2. Our results revealed that Luzp2 has predominant expression within the HCs and pillar cells. However, the loss of Luzp2 did not result in any changes in auditory threshold. HCs or synapse number and HC stereocilia morphology in Luzp2 knockout mice did not show any notable distinctions. This was the first study of the role of Luzp2 in hearing in mice, and our results provide important guidance for the screening of deafness genes.
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Data Availability Statement
The data sets used and analyzed during the present study are available from the corresponding author upon reasonable request.
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Acknowledgments
This work was supported by grants from the National Natural Science Foundation of China (81970884, 81900941, 81970885, 82371157, 82171145, 82271173, and 81771019), the Natural Science Foundation of Jiangsu Province (BK20190121 and BK20200133), the China Postdoctoral Science Foundation (2020M681555), and a Distinguished Young Scholarship supported by the Medical Science and Technology Development Foundation, Nanjing Department of Health (JQX20003).
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Cheng, C., Zhu, G., Wang, K. et al. Deletion of Luzp2 Does Not Cause Hearing Loss in Mice. Neurosci. Bull. (2024). https://doi.org/10.1007/s12264-024-01202-5
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DOI: https://doi.org/10.1007/s12264-024-01202-5