Skip to main content
SpringerLink
Log in

Sense to Tune: Engaging Microglia with Dynamic Neuronal Activity

  • Insight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Borst K, Dumas AA, Prinz M. Microglia: Immune and non-immune functions. Immunity 2021, 54: 2194–2208.

    Article  CAS  PubMed  Google Scholar 

  2. Umpierre AD, Wu LJ. How microglia sense and regulate neuronal activity. Glia 2021, 69: 1637–1653.

    Article  CAS  PubMed  Google Scholar 

  3. Wang Y, Huang Z. Microglia interact with neurons by forming somatic junctions. Neurosci Bull 2020, 36: 1085–1088.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Umpierre AD, Bystrom LL, Ying Y, Liu YU, Worrell G, Wu LJ. Microglial calcium signaling is attuned to neuronal activity in awake mice. eLife 2020, 9: e56502.

  5. Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V. Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation. Nat Neurosci 2021, 24: 355–367.

    Article  CAS  PubMed  Google Scholar 

  6. Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, et al. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science 2020, 367: 528–537.

    Article  PubMed  Google Scholar 

  7. Kettenmann H, Hanisch UK, Noda M, Verkhratsky A. Physiology of microglia. Physiol Rev 2011, 91: 461–553.

    Article  CAS  PubMed  Google Scholar 

  8. Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ. Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. J Neurosci 2014, 34: 10528–10540.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Wu LJ, Vadakkan KI, Zhuo M. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia 2007, 55: 810–821.

    Article  PubMed  Google Scholar 

  10. Liu YU, Ying Y, Li Y, Eyo UB, Chen T, Zheng J, et al. Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling. Nat Neurosci 2019, 22: 1771–1781.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Stowell RD, Sipe GO, Dawes RP, Batchelor HN, Lordy KA, Whitelaw BS, et al. Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex. Nat Neurosci 2019, 22: 1782–1792.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Gyoneva S, Traynelis SF. Norepinephrine modulates the motility of resting and activated microglia via different adrenergic receptors*. J Biol Chem 2013, 288: 15291–15302.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Hayashi Y, Koyanagi S, Kusunose N, Takayama F, Ryo Okada1 , Wu Z, et al. Diurnal spatial rearrangement of microglial processes through the rhythmic expression of P2Y12 receptors. J Neurol Disord 2013. Doi: https://doi.org/10.4172/2329-6895.1000120.

  14. Liu H, Wang X, Chen L, Chen L, Tsirka SE, Ge S, et al. Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice. Nat Commun 2021, 12: 4646.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Corsi G, Picard K, Castro MAD, Garofalo S, Tucci F, Chece G, et al. Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle. Glia 2022, 70: 89–105.

    Article  CAS  PubMed  Google Scholar 

  16. Holden SS, Grandi FC, Aboubakr O, Higashikubo B, Cho FS, Chang AH, et al. Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury. Science 2021, 373: eabj2685.

  17. Bi Q, Wang C, Cheng G, Chen N, Wei B, Liu X, et al. Microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity and limit hypertension. Immunity 2022, 55: 1466–1482.e9.

    Article  CAS  PubMed  Google Scholar 

  18. Victor MB, Leary N, Luna X, Meharena HS, Scannail AN, Bozzelli PL, et al. Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity. Cell Stem Cell 2022, 29: 1197–1212.e8.

    Article  CAS  PubMed  Google Scholar 

  19. Lin R, Zhou Y, Yan T, Wang R, Li H, Wu Z, et al. Directed evolution of adeno-associated virus for efficient gene delivery to microglia. Nat Methods 2022, 19: 976–985.

    Article  CAS  PubMed  Google Scholar 

  20. Dumas AA, Borst K, Prinz M. Current tools to interrogate microglial biology. Neuron 2021, 109: 2805–2819.

    Article  CAS  PubMed  Google Scholar 

  21. Binning W, Hogan-Cann AE, Yae Sakae D, Maksoud M, Ostapchenko V, Al-Onaizi M, et al. Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice. Brain Behav Immun 2020, 88: 791–801.

    Article  CAS  PubMed  Google Scholar 

  22. Yi MH, Liu YU, Umpierre AD, Chen T, Ying Y, Zheng J, et al. Optogenetic activation of spinal microglia triggers chronic pain in mice. PLoS Biol 2021, 19: e3001154.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This insight was supported by the National Key Research and Development Program of China (2017YFA0104200), the National Natural Science Foundation of China (82090033), Leading Talents in Scientific and Technological Innovation in Zhejiang Province (2021R52021), and a China Postdoctoral Science Foundation grant (2020M671693).

Author information

Authors and Affiliations

  1. Department of Neurobiology and Department of Neurology of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China

    Kelei Cao, Yaling Hu & Zhihua Gao

  2. Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University Medical Center, Zhejiang University, Hangzhou, 311121, China

    Kelei Cao, Yaling Hu & Zhihua Gao

  3. NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, 310058, China

    Kelei Cao, Yaling Hu & Zhihua Gao

Authors
  1. Kelei Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yaling Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zhihua Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yaling Hu or Zhihua Gao.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cao, K., Hu, Y. & Gao, Z. Sense to Tune: Engaging Microglia with Dynamic Neuronal Activity. Neurosci. Bull. 39, 553–556 (2023). https://doi.org/10.1007/s12264-022-01010-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-022-01010-9

Search

Navigation