Skip to main content
SpringerLink
Log in

Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord

  • RESEARCH HIGHLIGHT
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Finnerup NB, Kuner R, Jensen TS. Neuropathic pain: From mechanisms to treatment. Physiol Rev 2021, 101: 259–301.

    Article  CAS  Google Scholar 

  2. Price TJ, Basbaum AI, Bresnahan J, Chambers JF, de Koninck Y, Edwards RR. Transition to chronic pain: Opportunities for novel therapeutics. Nat Rev Neurosci 2018, 19: 383–384.

    Article  CAS  Google Scholar 

  3. Kohno K, Shirasaka R, Yoshihara K, Mikuriya S, Tanaka K, Takanami K, et al. A spinal microglia population involved in remitting and relapsing neuropathic pain. Science 2022, 376: 86–90.

    Article  CAS  Google Scholar 

  4. Inoue K, Tsuda M. Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci 2018, 19: 138–152.

    Article  CAS  Google Scholar 

  5. Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR. Microglia in pain: Detrimental and protective roles in pathogenesis and resolution of pain. Neuron 2018, 100: 1292–1311.

    Article  CAS  Google Scholar 

  6. Shemer A, Erny D, Jung S, Prinz M. Microglia plasticity during health and disease: An immunological perspective. Trends Immunol 2015, 36: 614–624.

    Article  CAS  Google Scholar 

  7. Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, et al. Microglial control of astrocytes in response to microbial metabolites. Nature 2018, 557: 724–728.

    Article  CAS  Google Scholar 

  8. Sideris-Lampretsas G, Malcangio M. Microglial heterogeneity in chronic pain. Brain Behav Immun 2021, 96: 279–289.

    Article  CAS  Google Scholar 

  9. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, et al. Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci 2016, 19: 94–101.

    Article  CAS  Google Scholar 

  10. Huang Y, Happonen KE, Burrola PG, O’Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol 2021, 22: 586–594.

    Article  CAS  Google Scholar 

  11. Mogil JS. Qualitative sex differences in pain processing: Emerging evidence of a biased literature. Nat Rev Neurosci 2020, 21: 353–365.

    Article  CAS  Google Scholar 

  12. Krieger CC, Neumann S, Gershengorn MC. TSH/IGF1 receptor crosstalk: Mechanism and clinical implications. Pharmacol Ther 2020, 209: 107502.

    Article  CAS  Google Scholar 

  13. Tansley S, Uttam S, Ureña Guzmán A, Yaqubi M, Pacis A, Parisien M, et al. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nat Commun 2022, 13: 843.

    Article  CAS  Google Scholar 

  14. Niehaus JK, Taylor-Blake B, Loo L, Simon JM, Zylka MJ. Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury. Neuron 2021, 109: 1274-1282.e6.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This research highlight was supported by the National Key R&D Program of China (2021ZD0202703), Zhejiang Provincial Natural Science Foundation (LZ18C090002), and the National Natural Science Foundation of China (81971050 and 82171206).

Author information

Authors and Affiliations

  1. Department of Anesthesiology and Department of Neurobiology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China

    Jing Yang, Shulan Xie, Shengmei Zhu & Zhen-Zhong Xu

  2. NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain–Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China

    Zhen-Zhong Xu

Authors
  1. Jing Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shulan Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shengmei Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhen-Zhong Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Shengmei Zhu or Zhen-Zhong Xu.

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yang, J., Xie, S., Zhu, S. et al. Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord. Neurosci. Bull. 39, 173–175 (2023). https://doi.org/10.1007/s12264-022-00932-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-022-00932-8

Search

Navigation