Skip to main content

Advertisement

SpringerLink
Log in

Surgical Management of Breast Cancer in Turkey: a 30-Year Single-Center Retrospective Study of 2531 Patients

  • Original Article
  • Published:
Indian Journal of Surgery Aims and scope Submit manuscript

Abstract

Mastectomy and lumpectomy are well-established surgical methods for the surgical treatment of breast cancer. The comparison of these methods within the 30-year period in terms of clinicopathological characteristics, recurrence, and survival patterns is required in order to provide aid in clinical decision-making. A total of 2531 women who underwent mastectomy or lumpectomy between 1982 and 2012 for primary invasive breast tumors were compared. Starting from 2003, similar variables for patients with primary invasive breast tumors who underwent sentinel node biopsy (SNB) were presented. Mastectomy was performed in 1870 patients and lumpectomy in 661. The median follow-up was 38 months for all patients. The ratio of mastectomy was lower for the patients who underwent SNB. There was no significant difference in breast cancer-related survival or disease-free survival between lumpectomy and mastectomy even after adjusting for the clinicopathological variables. Lumpectomy and mastectomy demonstrate similar survival rates for patients with invasive breast carcinoma. Tumor grade, stage, hormone receptor status, lymphovascular invasion, and distant recurrence have an impact on breast cancer-related survival.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Cardoso F, Costa A, Senkus E, Aapro M, André F, Barrios CH, Bergh J, Bhattacharyya G, Biganzoli L, Cardoso MJ, Carey L, Corneliussen-James D, Curigliano G, Dieras V, el Saghir N, Eniu A, Fallowfield L, Fenech D, Francis P, Gelmon K, Gennari A, Harbeck N, Hudis C, Kaufman B, Krop I, Mayer M, Meijer H, Mertz S, Ohno S, Pagani O, Papadopoulos E, Peccatori F, Pernault-Llorca F, Piccart MJ, Pierga JY, Rugo H, Shockney L, Sledge G, Swain S, Thomssen C, Tutt A, Vorobiof D, Xu B, Norton L, Winer E (2017 Jan 1) 3rd ESO–ESMO international consensus guidelines for advanced breast Cancer (ABC 3). Ann Oncol 28(1):16–33. https://doi.org/10.1093/annonc/mdw544

    Article  CAS  PubMed  Google Scholar 

  2. Winters S, Martin C, Murphy D, Shokar NK (2017) Chapter one- breast cancer epidemiology, prevention, and screening. Prog Mol Biol Transl Sci 151:1–32

    Article  CAS  Google Scholar 

  3. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359–E386

    Article  CAS  Google Scholar 

  4. Merino Bonilla JA, Torres Tabanera M, Ros Mendoza LH (2017) Breast cancer in the 21st century: From early detection to new therapies. Radiologia 59(5):368–379. https://doi.org/10.1016/j.rx.2017.06.003

    Article  CAS  PubMed  Google Scholar 

  5. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N (2002) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347(16):1233–1241

    Article  Google Scholar 

  6. Huang NS, Liu MY, Chen JJ, Yang BL, Xue JY, Quan CL, Mo M, Liu GY, Shen ZZ, Shao ZM, Wu J (2016) Surgical management of breast cancer in China: a 15-year single-center retrospective study of 18,502 patients. Medicine (Baltimore) 95(45):e4201

    Article  Google Scholar 

  7. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E (2002) Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347(16):1227–1232

    Article  Google Scholar 

  8. van Dongen JA, Voogd AC, Fentiman IS, Legrand C, Sylvester RJ, Tong D et al (2000) Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. Natl Cancer Inst 92(14):1143–1150

    Article  Google Scholar 

  9. Hartmann-Johnsen OJ, Kåresen R, Schlichting E, Nygård JF (2017) Better survival after breast-conserving therapy compared to mastectomy when axillary node status is positive in early-stage breast cancer: a registry-based follow-up study of 6387 Norwegian women participating in screening, primarily operated between 1998 and 2009. World J Surg Oncol 15(1):118. https://doi.org/10.1186/s12957-017-1184-6

    Article  PubMed  PubMed Central  Google Scholar 

  10. Saadatmand S, Bretveld R, Siesling S, Tilanus-Linthorst MA (2015) Influence of tumour stage at breast cancer detection on survival in modern times: population based study in 173 797 patients. BMJ (Clin Res Ed) 351(h4901). https://doi.org/10.1136/bmj.h4901

  11. Blichert-Toft M, Nielsen M, Düring M, Møller S, Rank F, Overgaard M, Mouridsen HT (2008) Long-term results of breast conserving surgery vs. mastectomy for early stage invasive breast cancer: 20-year follow-up of the Danish randomized DBCG-82TM protocol. Acta Oncol 47(4):672–681. https://doi.org/10.1080/02841860801971439

    Article  PubMed  Google Scholar 

  12. de Boniface J, Frisell J, Bergkvist L, Andersson Y (2017) Swedish Breast Cancer Group and the Swedish Society of Breast Surgery. Ten-year report on axillary recurrence after negative sentinel node biopsy for breast cancer from the Swedish Multicentre Cohort Study. Br J Surg 104(3):238–247. https://doi.org/10.1002/bjs.10411

    Article  PubMed  Google Scholar 

  13. Harris JR, Lippman ME, Veronesi U, Willett W (1992) Breast cancer. N Engl J Med 327(5):319–328. https://doi.org/10.1056/nejm199207303270505

    Article  CAS  PubMed  Google Scholar 

  14. Berry DA, Cronin KA, Plevritis SK, Fryback DG, Clarke L, Zelen M, Mandelblatt JS, Yakovlev AY, Habbema JD, Feuer EJ, Cancer Intervention and Surveillance Modeling Network (CISNET) Collaborators (2005) Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med 353:1784–1792

    Article  CAS  Google Scholar 

  15. Horiguchi J, Iino Y, Koibuchi Y, Yokoe T, Takei H, Yamakawa M, Nakajima T, Oyama T, Ando T, Ishida T, Endo K, Takai Y, Suzuki H, Fujii T, Yokomori T, Morishita Y (2002) Breast-conserving therapy versus modified radical mastectomy in the treatment of early breast cancer in Japan. Breast Cancer 9(2):160–165

    Article  Google Scholar 

  16. Maishman T, Cutress RI, Hernandez A, Gerty S, Copson ER, Durcan L et al (2016) Local recurrence and breast oncological surgery in young women with breast cancer: the POSH Observational Cohort Study. Ann Surg 266(1):165–172

    Article  Google Scholar 

  17. Miller AB, Wall C, Baines CJ, Sun P, To T, Narod SA (2014) Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. BMJ 348. https://doi.org/10.1136/bmj.g366

  18. Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, Bannon F, Ahn JV, Johnson CJ, Bonaventure A, Marcos-Gragera R, Stiller C, Azevedo e Silva G, Chen WQ, Ogunbiyi OJ, Rachet B, Soeberg MJ, You H, Matsuda T, Bielska-Lasota M, Storm H, Tucker TC, Coleman MP, CONCORD Working Group (2014) Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet. 385(9972):977–1010

    Article  Google Scholar 

  19. Veronesi U, Galimberti V, Paganelli G, Maisonneuve P, Viale G, Orecchia R, Luini A, Intra M, Veronesi P, Caldarella P, Renne G, Rotmensz N, Sangalli C, de Brito Lima L, Tullii M, Zurrida S (2009) Axillary metastases in breast cancer patients with negative sentinel nodes: a follow-up of 3548 cases. Eur J Cancer 45(8):1381–1388. https://doi.org/10.1016/j.ejca.2008.11.041

    Article  PubMed  Google Scholar 

  20. Poodt IGM, Walstra CJEF, Vugts G, Maaskant-Braat AJG, Voogd AC, Schipper RJ et al (2019) Low risk of development of a regional recurrence after an unsuccessful repeat sentinel lymph node biopsy in patients with ipsilateral breast tumor recurrence. Ann Surg Oncol 26(8):2417–2427. https://doi.org/10.1245/s10434-019-07272-4

    Article  PubMed  Google Scholar 

  21. Galimberti V, Manika A, Maisonneuve P, Corso G, Salazar Moltrasio L, Intra M, Gentilini O, Veronesi P, Pagani G, Rossi E, Bottiglieri L, Viale G, Rotmensz N, de Cicco C, Grana CM, Sangalli C, Luini A (2014) Long-term follow-up of 5262 breast cancer patients with negative sentinel node and no axillary dissection confirms low rate of axillary disease. Eur J Surg Oncol 40(10):1203–1208. https://doi.org/10.1016/j.ejso.2014.07.041

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Health Sciences, Bilgi University, Istanbul, Turkey

    Fatih Can Karaca

  2. Department of General Surgery, Okmeydanı Education and Research Hospital, Istanbul, Turkey

    Ali Pusane

  3. Department of Medical Oncology, Istanbul University Cerrahpaşa-Cerrahpaşa Medical Faculty, Istanbul, Turkey

    Hande Zeynep Turna

  4. Department of General Surgery, Istanbul University Cerrahpaşa-Cerrahpaşa Medical Faculty, Istanbul, Turkey

    Varol Çelik & Ceyhun Oral

Authors
  1. Fatih Can Karaca
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ali Pusane
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hande Zeynep Turna
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Varol Çelik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ceyhun Oral
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fatih Can Karaca.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic Supplementary Material

ESM 1

(DOC 29 kb)

ESM 2

(DOC 101 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Karaca, F.C., Pusane, A., Turna, H.Z. et al. Surgical Management of Breast Cancer in Turkey: a 30-Year Single-Center Retrospective Study of 2531 Patients. Indian J Surg 83, 28–37 (2021). https://doi.org/10.1007/s12262-019-01954-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12262-019-01954-9

Keywords

Search

Navigation