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Exosomes as novel biomarkers in anticancer therapy

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Abstract

Extracellular vesicles, particularly small exosomes with a size between 40 and 120 nm, contain complex information. Most importantly, exosomes may transfer this information to recipient cells and alter their cellular programme. If decoded, this information reveals ongoing malignant processes within the organism such as drug resistance or metastases formation (functional biomarker). As this information is composed of RNA, DNA fragments, proteins and metabolites, these molecules may also serve as molecular biomarker. Exosomes are generated from parental cells, frequently under disease conditions. Thus, exosomes share significant information with their origin including mutations of the malignant lesion. Tumour characteristics can therefore be retrieved in circulating exosomes, which opens a complete new approach in cancer diagnosis: the liquid biopsy.

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References

  1. Yanez-Mo M, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015;4:27066.

    PubMed  Google Scholar 

  2. Andaloussi SEL, et al. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013;12(5):347–57.

    Article  Google Scholar 

  3. Corrado C, et al. Exosomes as intercellular signaling organelles involved in health and disease: basic science and clinical applications. Int J Mol Sci. 2013;14(3):5338–66.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  4. Kahlert C, Kalluri R. Exosomes in tumor microenvironment influence cancer progression and metastasis. J Mol Med (Berl). 2013;91(4):431–7.

    Article  CAS  Google Scholar 

  5. Turchinovich A, et al. Circulating miRNAs: cell-cell communication function? Front Genet. 2013;4:119.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  6. Thakur BK, et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res. 2014;24(6):766–9.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  7. Camussi G, et al. Exosomes/microvesicles as a mechanism of cell-to-cell communication. Kidney Int. 2010;78(9):838–48.

    Article  PubMed  CAS  Google Scholar 

  8. An T, et al. Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis. J Extracell Vesicles. 2015;4:27522.

    PubMed  Google Scholar 

  9. Peinado H, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012;18(6):883–91.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  10. Fong MY, et al. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015;17(2):183–94.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  11. Melo SA, et al. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell. 2014;26(5):707–21.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  12. O’Brien K, et al. Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells. Eur J Cancer. 2013;49(8):1845–59.

    Article  PubMed  Google Scholar 

  13. Zomer A, et al. In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior. Cell. 2015;161(5):1046–57.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  14. Senfter D, et al. Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro. Hum Mol Genet. 2015;24(13):3689–98.

    PubMed  CAS  Google Scholar 

  15. Corcoran C, et al. Docetaxel-resistance in prostate cancer: evaluating associated phenotypic changes and potential for resistance transfer via exosomes. PLoS One. 2012;7(12):e50999.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  16. Boelens MC, et al. Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. Cell. 2014;159(3):499–513.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  17. Rabinowits G, et al. Exosomal microRNA: a diagnostic marker for lung cancer. Clin Lung Cancer. 2009;10(1):42–6.

    Article  PubMed  CAS  Google Scholar 

  18. Bryant RJ, et al. Changes in circulating microRNA levels associated with prostate cancer. Br J Cancer. 2012;106(4):768–74.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  19. Takeshita N, et al. Serum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma. Br J Cancer. 2013;108(3):644–52.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  20. Melo SA, et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature. 2015;523(7559):177–82.

    Article  PubMed  CAS  Google Scholar 

  21. Marleau AM, et al. Exosome removal as a therapeutic adjuvant in cancer. J Transl Med. 2012;10:134.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  22. Tan A, De La Pena H, Seifalian AM. The application of exosomes as a nanoscale cancer vaccine. Int J Nanomedicine. 2010;5:889–900.

    PubMed  CAS  PubMed Central  Google Scholar 

  23. Morse MA, et al. A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J Transl Med. 2005;3(1):9.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Robert M. Mader.

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Senfter, D., Mader, R.M. Exosomes as novel biomarkers in anticancer therapy. memo 8, 231–234 (2015). https://doi.org/10.1007/s12254-015-0245-1

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  • DOI: https://doi.org/10.1007/s12254-015-0245-1

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