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ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer

  • Original Article
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Pathology & Oncology Research

Abstract

N6-methyladenosine (m6A) demethylase ALKBH5 is best known for modulating transcript modification in plenty of human malignancies, but its role in the progression of colon cancer is not well understood. In the present study, we identified the tumor repressive role of ALKBH5 in colon cancer. ALKBH5 was downregulated in human colon cancer tissues, where its decreased expression significantly correlated with distant metastasis and American Joint Committee on Cancer (AJCC) stage. ALKBH5 was also an independent prognostic indicator of overall survival and disease-free survival in colon cancer patients. Furthermore, functional studies established that overexpression of ALKBH5 inhibited colon cancer cells invasion in vitro and metastasis in vivo. These results indicated that ALKBH5 significantly inhibits tumor progression and serves as a potential therapeutic target for colon cancer.

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Acknowledgements

This work was supported by Science and Technology Project of Chongqing Education Committee (No.KJ1600210) and Shandong Province Natural Science Foundation of China (No. ZR2013HL054).

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Author notes

  1. Peipei Yang and Qian Wang contributed equally to this work.

Authors and Affiliations

  1. Department of General Surgery, The First Affiliated Hospital of Anhui University of Science and Technology, No. 203, huaibin road, Huainan, 232000, Anhui Province, China

    Peipei Yang

  2. Department of General Surgery, Huainan First People’s Hospital, No. 203, huaibin road, Huainan, 232000, Anhui Province, China

    Peipei Yang

  3. Department of Central Laboratory, Taian City Central Hospital, Shandong First Medical University & Shangdong Academy of Medical Sciences, 29 Longtan Road, Taishan District, Taian,, 271000, Shandong Province, China

    Qian Wang & Aihua Liu

  4. Hang Zhou Di’an Medical Laboratory, 329 Jinpeng Road, Xihu District, Hangzhou, 310030, Zhejiang Province, China

    Jun Zhu

  5. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China

    Jinzhou Feng

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  1. Peipei Yang
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  2. Qian Wang
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  3. Aihua Liu
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  4. Jun Zhu
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Correspondence to Jinzhou Feng.

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Yang, P., Wang, Q., Liu, A. et al. ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer. Pathol. Oncol. Res. 26, 1615–1623 (2020). https://doi.org/10.1007/s12253-019-00737-7

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  • DOI: https://doi.org/10.1007/s12253-019-00737-7

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