Abstract
Veterinary drugs (VDs) are regulated to prevent their abuse or misuse and protect humans that consume animal-based food products from exposure to VD residues. VD residues are managed according to the maximum residue limits (MRLs) or by prohibiting the use of VDs based on their residual properties and toxicities. However, all VD residues, even those that are not managed by MRLs, in animal-based food products will be regulated for public health improvement. Accordingly, herein, the applicability of an existing multiclass analytical method for the analysis of 59 VDs in fishery foods was validated. Applicability of this method to the analysis of VDs in livestock foods has already been confirmed. In this method, the sample was extracted with water:acetonitrile (1:4, v/v) followed by cooling, concentration, and analysis via liquid chromatography-mass spectrometry. Accuracies and precisions for three fishery foods (namely, flat fish, eel, and shrimp) were 63.7–120% and 1.9–30%, respectively, and a minimum of 63% (44/70) compounds could be quantified. This method is expected to improve the capabilities and efficiencies of monitoring VD residues in animal-based food products and will enhance food safety.
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Funding
This study was supported by a grant (22191MFDS337) from the Ministry of Food and Drug Safety in 2022.
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Sun-Young Park: conceptualization, writing—original draft.
Hyunjin Park: methodology, validation.
Ji-Young Kim: methodology, project administration, writing—review and editing.
Jang-Deok Choi: project administration, supervision.
Gui-Im Moon: project administration, supervision.
Dong Woo Shin: project administration, supervision.
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Sun-Young Park declares that she has no conflict of interest. Hyunjin Park declares that she has no conflict of interest. Ji-Young Kim declares that she has no conflict of interest. Jang-Deok Choi declares that he has no conflict of interest. Gui-Im Moon declares that she has no conflict of interest. Dong Woo Shin declares that he has no conflict of interest.
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Park, S., Park, H., Kim, JY. et al. Validation of a Method Based on Liquid Chromatography-Tandem Mass Spectrometry for Multiclass Screening and Analysis of 59 Veterinary Drugs in Fishery Foods. Food Anal. Methods 17, 61–82 (2024). https://doi.org/10.1007/s12161-023-02551-z
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DOI: https://doi.org/10.1007/s12161-023-02551-z