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The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

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Abstract

Objective

Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.

Method

We performed polysomnography (PSG) and Aβ imaging with [11C]-Pittsburgh compound B PET computed tomography (11C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h).

Results

The abnormal accumulation of enhanced 11C-PiB PET was observed only one patient with severe, but not the most severe.

Conclusions

The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.

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Acknowledgements

We sincerely appreciate Yukiko Kawamura, Psychiatric Social Worker, for her technical help and efforts.

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Authors and Affiliations

  1. Sleep Apnea Center, Kyushu University Hospital, Fukuoka, Japan

    Sakiko Shimizu Handa & Shinichi Ando

  2. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Shingo Baba

  3. Department of Neurology Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Kenichiro Yamashita

  4. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Mari Nishizaka

Authors
  1. Sakiko Shimizu Handa
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  2. Shingo Baba
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  3. Kenichiro Yamashita
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  4. Mari Nishizaka
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  5. Shinichi Ando
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Corresponding author

Correspondence to Shinichi Ando.

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Conflict of interest

Author Sakiko Shimizu Handa, Shingo Baba, Kenichiro Yamashita and Mari Nishizaka declare that they have no conflict of interest. Shinichi Ando obtained unrestricted research funding from Teijin Home Health and Philips Respironics.

Ethical committee permission

This study was approved by the Institutional Review Board of Kyushu University Hospital.

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Informed consent was obtained from all individual participants included in the study.

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Handa, S.S., Baba, S., Yamashita, K. et al. The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function. Ann Nucl Med 33, 541–544 (2019). https://doi.org/10.1007/s12149-019-01349-6

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  • DOI: https://doi.org/10.1007/s12149-019-01349-6

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