Skip to main content

Advertisement

SpringerLink
Log in

A Systematic Review of Adenoid Ameloblastoma: A Newly Recognized Entity

  • Research
  • Published:
Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Background

Recently, a new odontogenic tumor has been described, the so-called adenoid ameloblastoma (AdAM). The aim of this review was to determine the clinical and imaging features of AdAM and to describe its main histopathological findings.

Methods

The systematic review included published cases with a diagnosis of AdAM in the gnathic bones, which had sufficient clinical, imaging, and histopathological data to confirm its diagnosis. The following histopathological diagnostic criteria were adopted: presence of ameloblastoma-like components, duct-like structures, spiral cellular condensations, and a cribriform architecture.

Results

Fifteen articles, corresponding to 30 cases of AdAM, were selected. Most cases affected men (63.3%), with a slight preference for the mandible (16:14) and the posterior region of gnathic bones was the most commonly affected site. The mean age at diagnosis was 40.8 years. Clinically, the lesions usually presented as a swelling (53.3%) and, radiographically, as a well-defined radiolucency (33.4%). Surgical resection (40%) was the most frequently adopted treatment and recurrence occurred in 30% of cases. Microscopic examination showed cribriform areas in most AdAM cases (93.3%); duct-like structures and spiral cellular condensations were seen in 100% of the cases.

Conclusion

The small number of reported cases, the existence of erroneous diagnoses, and the adoption of initial conservative management make it difficult to determine whether AdAM has a higher risk of recurrence or more aggressive biological behavior than conventional ameloblastomas.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Laborde A, Nicot R, Wojcik T et al (2017) Ameloblastoma of the jaws: management and recurrence rate. Eur Ann Otorhinolaryngol Head Neck Dis 134:7–11. https://doi.org/10.1016/j.anorl.2016.09.004

    Article  CAS  PubMed  Google Scholar 

  2. Almeida RAC, Andrade ES, Barbalho JC et al (2016) Recurrence rate following treatment for primary multicystic ameloblastoma: systematic review and meta-analysis. Int J Oral Maxillofac Surg 45:359–367. https://doi.org/10.1016/j.ijom.2015.12.016

    Article  PubMed  Google Scholar 

  3. Oginni FO, Stoelinga PJ, Ajike SA et al (2015) A prospective epidemiological study on odontogenic tumours in a black african population, with emphasis on the relative frequency of ameloblastoma. Int J Oral Maxillofac Surg 44:1099–1105. https://doi.org/10.1016/j.ijom.2015.03.018

    Article  CAS  PubMed  Google Scholar 

  4. Hendra FN, Natsir Kalla DS, Van Cann EM et al (2019) Radical vs conservative treatment of intraosseous ameloblastoma: systematic review and meta-analysis. Oral Dis 25:1683–1696. https://doi.org/10.1111/odi.13014

    Article  PubMed  Google Scholar 

  5. Hendra FN, Van Cann EM, Helder MN et al (2020) Global incidence and profile of ameloblastoma: a systematic review and meta-analysis. Oral Dis 26:12–21. https://doi.org/10.1111/odi.13031

    Article  PubMed  Google Scholar 

  6. Yang R, Liu Z, Peng C et al (2017) Maxillary ameloblastoma: factors associated with risk of recurrence. Head Neck 39:996–1000. https://doi.org/10.1002/hed.24720

    Article  PubMed  Google Scholar 

  7. Kelppe J, Hagström J, Sorsa T (2019) Ameloblastoma: a retrospective single institute study of 34 subjects. Acta Odontol Scand 77:82–87. https://doi.org/10.1080/00016357.2018.1532530

    Article  CAS  PubMed  Google Scholar 

  8. El-Naggar AK, Chan JKC, Grandis JR et al (2017) Odontogenic and maxillofacial bone tumours. WHO classification of head and neck tumours, 4th edn. IARC, Lyon, pp 205–260

    Google Scholar 

  9. Kreppel M, Zöller J (2017) Ameloblastoma-Clinical, radiological, and therapeutic findings. Oral Dis 24:63–66. https://doi.org/10.1111/odi.12702

    Article  Google Scholar 

  10. Gneep DR, Bishop JA (2020) Gnepp’s diagnostic surgical pathology of the head and neck, 3rd edn. Elsevier, Amsterdam

    Google Scholar 

  11. Jayasooriya PR, Abeyasinghe WAMUL, Liyanage RLPR et al (2022) Diagnostic Enigma of Adenoid Ameloblastoma: Literature Review based evidence to consider it as a new sub type of Ameloblastoma. Head Neck Pathol 16:344–352. https://doi.org/10.1007/s12105-021-01358-w

    Article  PubMed  Google Scholar 

  12. WHO Classification of Tumours Editorial Board. Head and neck tumours (2022) Lyon (France): International Agency for Research on Cancer. WHO classification of tumours series, 5th ed. Vol. 9 https://publications.iarc.fr/

  13. Vered M, Wright JM (2022) Update from the 5th edition of the World Health Organization classification of head and neck tumors: odontogenic and maxillofacial bone tumours. Head Neck Pathol 16:63–75. https://doi.org/10.1007/s12105-021-01404-7

    Article  PubMed  PubMed Central  Google Scholar 

  14. Sweeney RT, McClary AC, Myers BR et al (2015) Identification of recurrent SMO and BRAF mutations in ameloblastomas. Nat Genet 47(1):97

    Article  CAS  Google Scholar 

  15. Soluk-Tekkesin M, Wright JM (2022) The World Health Organization classification of odontogenic lesions: a summary of the changes of the 2022, 5th Edn. Turk Patoloji Derg 38:168–184. https://doi.org/10.5146/tjpath.2022.01573

    Article  PubMed  PubMed Central  Google Scholar 

  16. Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151:264–269. https://doi.org/10.7326/0003-4819-151-4-200908180-00135

    Article  PubMed  Google Scholar 

  17. Gagnier JJ, Kienle G, Altman DG et al (2013) The CARE guidelines: consensus-based clinical case reporting guideline development. Glob Adv Health Med 2:38–43. https://doi.org/10.7453/gahmj.2013.008

    Article  PubMed  PubMed Central  Google Scholar 

  18. Adorno-Farias D, Muniz VRVM, Soares AP et al (2018) Ameloblastoma with adenoid features: a series of eight cases. Acta Histochem 120:468–476. https://doi.org/10.1016/j.acthis.2018.05.006

    Article  PubMed  Google Scholar 

  19. Jofre SA, Roth M, Lahouti AH et al (2022) Ameloblastoma with adenoid features: case report with cyto-histopathologic correlation and molecular findings. Diagn Cytopathol 50:E140–E145. https://doi.org/10.1002/dc.24929

    Article  PubMed  Google Scholar 

  20. Khalele BAO, Al-Shiaty RA (2016) Adenoid ameloblastoma with dentinoid and cellular atypia: a rare case report. Ital J Med 10:238–240. https://doi.org/10.4081/itjm.2016.639

    Article  Google Scholar 

  21. Loyola AM, Cardoso SV, de Faria PR et al (2015) Adenoid ameloblastoma: clinicopathologic description of five cases and systematic review of the current knowledge. Oral Surg Oral Med Oral Pathol Oral Radiol 120:368–377. https://doi.org/10.1016/j.oooo.2015.05.011

    Article  PubMed  Google Scholar 

  22. Coura BP, Dos Santos JN, Fonseca FP et al (2021) Adenoid ameloblastoma with dentinoid is molecularly different from ameloblastomas and adenomatoid odontogenic tumors. J Oral Pathol Med 50:1067–1071. https://doi.org/10.1111/jop.13243

    Article  CAS  PubMed  Google Scholar 

  23. Tajima Y, Sakamoto E, Yamamoto Y (1992) Odontogenic cyst giving rise to an adenomatoid odontogenic tumor: report of a case with peculiar features. J Oral Maxillofac Surg 50:190–193. https://doi.org/10.1016/0278-2391(92)90370-f

    Article  CAS  PubMed  Google Scholar 

  24. Matsumoto Y, Mizoue K, Seto K (2001) Atypical plexiform ameloblastoma with dentinoid: adenoid ameloblastoma with dentinoid. J Oral Pathol Med 30:251–254. https://doi.org/10.1034/j.1600-0714.2001.300410.x

    Article  CAS  PubMed  Google Scholar 

  25. Evans BL, Carr RF, Phillipe LJ (2004) Adenoid ameloblastoma with dentinoid: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:583–588. https://doi.org/10.1016/j.tripleo.2004.02.077

    Article  PubMed  Google Scholar 

  26. Ide F, Mishima K, Saito I, Kusama K (2009) Diagnostically challenging epithelial odontogenic tumors: a selective review of 7 jawbone lesions. Head Neck Pathol 3:18–26. https://doi.org/10.1007/s12105-009-0107-4

    Article  PubMed  PubMed Central  Google Scholar 

  27. Saxena K, Jose M, Chatra LK, Sequiera J (2012) Adenoid ameloblastoma with dentinoid. J Oral Maxillofac Pathol 16:272–276. https://doi.org/10.4103/jomfp.JOMFP_53_15

    Article  PubMed  PubMed Central  Google Scholar 

  28. Pandiar D, Gopinath D (2022) Adenoid ameloblastoma: the histological paradox. Head Neck Pathol 16:538–539. https://doi.org/10.1007/s12105-021-01372-y

    Article  PubMed  Google Scholar 

  29. Brown NA, Rolland D, McHugh JB et al (2014) Activating FGFR2-RAS-BRAF mutations in ameloblastoma. Clin Cancer Res 20:5517–5526. https://doi.org/10.1158/1078-0432.CCR-14-1069

    Article  CAS  PubMed  Google Scholar 

  30. Sweeney RT, McClary AC, Myers BR et al (2014) Identification of recurrent SMO and BRAF mutations in ameloblastomas. Nat Genet 46:722–725. https://doi.org/10.1038/ng.2986

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Gondak RO, Mariano FV, de Sousa SF et al (2020) CTNNB1 and APC mutations in odontogenic carcinoma with dentinoid. Oral Surg Oral Med Oral Pathol Oral Radiol 129:e249–e256. https://doi.org/10.1016/j.oooo.2019.08.017

    Article  PubMed  Google Scholar 

  32. Gomes CC, de Sousa SF, de Menezes GH et al (2016) Recurrent KRAS G12V pathogenic mutation in adenomatoid odontogenic tumours. Oral Oncol 56:e3–e5. https://doi.org/10.1016/j.oraloncology.2016.03.001

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

This study was not supported by any funding.

Author information

Authors and Affiliations

  1. Department of Oral Pathology, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, CEP 59056-000, Brazil

    Hannah Gil de Farias Morais, Rani Iani Costa Gonçalo, Carla Samily de Oliveira Costa, Hévila de Figueiredo Pires, Rodrigo Porpino Mafra, Márcia Cristina da Costa Miguel & Roseana de Almeida Freitas

  2. Piracicaba School of Dentistry, State University of Campinas, Piracicaba, São Paulo, Brazil

    Everton Freitas de Morais

Authors
  1. Hannah Gil de Farias Morais
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rani Iani Costa Gonçalo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carla Samily de Oliveira Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hévila de Figueiredo Pires
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rodrigo Porpino Mafra
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Everton Freitas de Morais
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Márcia Cristina da Costa Miguel
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Roseana de Almeida Freitas
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

HGFM: conceptualization, data curation, formal analysis, investigation, methodology resources, software, validation, visualization, roles/writing—original draft, and writing—review and editing. RICG: data curation, formal analysis, visualization, and roles/writing—original draft. CSOC: data curation, formal analysis, visualization, and roles/writing—original draft. HFP: investigation and roles/writing—original draft. RPM: writing—review and editing, investigation, and roles/writing—original draft. EFM: writing—review and editing, investigation, and roles/writing—original draft. MCCM: project administration, visualization, and writing—review and editing. RAF: formal analysis, investigation, methodology resources, visualization, and writing—review and editing.

Corresponding author

Correspondence to Roseana de Almeida Freitas.

Ethics declarations

Competing Interests

The authors declare no competing interests.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

For this type of study informed consent is not required.

Consent for Publication

For this type of study consent for publication is not required.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary Table 1. Summary of clinical data of the studies included in the systematic review (DOCX 29.3 kb)

12105_2023_1574_MOESM2_ESM.docx

Supplementary Table 2.Summary of histopathological and molecular data of the studies included in thesystematic review (DOCX 31.6 kb)

Supplementary Table 3.Summary of scores for CARE checklist items (DOCX 21.7 kb)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

de Farias Morais, H.G., Gonçalo, R.I.C., de Oliveira Costa, C.S. et al. A Systematic Review of Adenoid Ameloblastoma: A Newly Recognized Entity. Head and Neck Pathol 17, 688–696 (2023). https://doi.org/10.1007/s12105-023-01574-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12105-023-01574-6

Keywords

Search

Navigation