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Immunohistochemical Coexpression of MUC1 and MUC4 in Oral Leukoplakia and Oral Squamous Cell Carcinoma

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Abstract

MUC1 and MUC4 are two transmembranous proteins, which have been seen to express aberrantly in various human neoplasms and advocated as independent prognostic markers. Till now no extensive studies have been carried out on combined expression of MUC1 and MUC4 in oral leukoplakia and Oral squamous cell carcinoma. This study is an endeavour to evaluate Immunohistochemical coexpression of MUC1 and MUC4 in Oral Leukoplakia and Oral squamous cell carcinoma and furthr establish them as prognostic markers. Immunohistochemical analysis of MUC1 and MUC4 was done on 24 cases of Oral squamous cell carcinoma, 24 cases of leukoplakia and 12 normal oral mucosal tissues. Chi square test and one way ANOVA test were employed for statistical analysis. Normal oral mucosa and leukoplakia group showed higher frequency of negative immunoexpression compared to oral squamous cell carcinoma group. Furthur in Oral squamous cell carcinoma group, higher frequency of double positive coexpression in well and moderately differentiated oral squamous cell carcinoma and single positive coexpression in poorly differentiated oral squamous cell carcinoma was obtained. A definite rise of immunoexpression of MUC1 and MUC4 was observed from normal oral mucosa to leukoplakia to oral squamous cell carcinoma indicative of their contribution as diagnostic and prognostic markers.

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Authors and Affiliations

  1. Department of Oral Pathology and Microbiology, Post Graduate Institute of Dental Sciences, Pt.BD. Sharma University, Rohtak, Haryana, India

    Renu Rathee, Anju Devi, Anjali Narwal & Mala Kamboj

  2. Department of Pathology, Post Graduate Institute of Medical Sciences, Pt.BD. Sharma University, Rohtak, Haryana, India

    Sunita Singh

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  1. Renu Rathee
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  2. Anju Devi
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  3. Anjali Narwal
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  4. Mala Kamboj
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  5. Sunita Singh
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Correspondence to Renu Rathee.

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This study protocol was submitted to Institutional ethical committee for evaluation and clearance. The ethical clearance number was obtained vide Letter No. PGIDS/IEC/2018/15 dated 30.11.18.

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Rathee, R., Devi, A., Narwal, A. et al. Immunohistochemical Coexpression of MUC1 and MUC4 in Oral Leukoplakia and Oral Squamous Cell Carcinoma. Head and Neck Pathol 15, 831–842 (2021). https://doi.org/10.1007/s12105-021-01291-y

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  • DOI: https://doi.org/10.1007/s12105-021-01291-y

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