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Synaptophysin Positive Glomus Tumor of Trachea Simulating Typical Carcinoid: A Potential trap

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Abstract

Glomus tumors (GTs) are uncommon benign tumors, accounting for <2% of all soft tissue tumors and usually occur within the dermis or subcutis of distal extremities. Primary tracheal GT is rare, and to date less than 40 tracheal GTs have been reported. Tracheal GT usually present as a polypoidal mass. They express smooth muscle markers, and are negative for cytokeratin (CK) and neuroendocrine markers on immunohistochemistry (IHC). We here report a case of tracheal GT showing diffuse strong aberrant immunoexpression for synaptophysin, initially construed as carcinoid. Focal synaptophysin expression has been described in few gastric GTs, and a nasal GT. Diligent histomorphological examination and careful selection of IHC panel helps in clinching the diagnosis. Complete resection is the standard treatment of modality.

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Authors and Affiliations

  1. Department of Histopathology and Cytopathology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India

    Meenakshi Kamboj, Garima Durga, Sunil Pasricha, Gurudutt Gupta, Anila Sharma & Anurag Mehta

  2. Department of Thoracic Oncosurgery, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India

    L. M. Darlong

  3. Department of Radiology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India

    Ankush Jajodia

  4. Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India

    Venkata Pradeep Babu Koyyala

Authors
  1. Meenakshi Kamboj
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  2. Garima Durga
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  3. Sunil Pasricha
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  4. L. M. Darlong
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  5. Ankush Jajodia
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  6. Gurudutt Gupta
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  7. Anila Sharma
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  8. Venkata Pradeep Babu Koyyala
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  9. Anurag Mehta
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Contributions

SP, MK, LMD and VPBK substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data. SP, GG, AS, GD and AJ drafting the article and revising it critically for important intellectual content. SP, MK and AM final approval of the version to be published. MK and SP agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Meenakshi Kamboj.

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Kamboj, M., Durga, G., Pasricha, S. et al. Synaptophysin Positive Glomus Tumor of Trachea Simulating Typical Carcinoid: A Potential trap. Head and Neck Pathol 15, 994–998 (2021). https://doi.org/10.1007/s12105-020-01230-3

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  • DOI: https://doi.org/10.1007/s12105-020-01230-3

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