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Liver Involvement in Congenital Hypopituitarism

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Abstract

Objective

Cholestatic jaundice in early infancy is a complex diagnostic challenge. Cholestasis caused by endocrine disease is rare and poorly recognized. The aim of this paper is to report patients with liver dysfunctions resulting from hypopituitarism.

Methods

Six patients with liver dysfunction diagnosed as hypopituitarism were studied and followed up at Uludag University Faculty of Medicine.

Results

The median age of the patients at first presentation was 2.5 mo. Three patients were diagnosed with congenital hypopituitarism at the first visit, and the other three were diagnosed during follow-up. Serum aminotransferase levels were very high in two patients and only moderately elevated in the others. Combined adrenal, thyroid, and growth hormone deficiencies were diagnosed in two patients, while remaining 4 patients had various combinations of adrenal, thyroid, and growth hormone deficiencies. Liver function abnormalities resolved between 10 d and 2 mo follow-up after hormone replacement therapy.

Conclusions

Abnormal liver biochemical test results due to hormonal deficiencies in infants should be considered in the differential diagnosis by pediatricians. Hormone replacement therapy is the basis of treatment.

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Authors and Affiliations

  1. Department of Pediatric Gastroenterology, Hepatology and Nutrition, Erciyes University Faculty of Medicine, Kayseri, Turkey

    Derya Altay

  2. Department of Pediatric Endocrinology, Uludag University Faculty of Medicine, Bursa, Turkey

    Erdal Eren & Omer Tarım

  3. Department of Pediatric Gastroenterology, Hepatology and Nutrition, Uludag University Faculty of Medicine, Bursa, Turkey

    Tanju Basarır Ozkan & Taner Ozgur

Authors
  1. Derya Altay
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  2. Erdal Eren
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  3. Tanju Basarır Ozkan
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  4. Taner Ozgur
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  5. Omer Tarım
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Correspondence to Derya Altay.

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Altay, D., Eren, E., Ozkan, T.B. et al. Liver Involvement in Congenital Hypopituitarism. Indian J Pediatr 86, 412–416 (2019). https://doi.org/10.1007/s12098-018-2833-7

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  • DOI: https://doi.org/10.1007/s12098-018-2833-7

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