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Cutaneous toxicities of new treatments for melanoma

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Abstract

New drugs against advanced melanoma have emerged during last decade. Target therapy and immunotherapy have changed the management of patients with metastatic disease. Along with its generalized use, drug toxicities have appeared and the skin is the target organ of a significant part of them. This revision summarizes the most common side effects and consensus management to improve the compliance of therapies and patients’ quality of life. Among the BRAF inhibitors, main cutaneous side effects are photosensitivity, plantar hyperkeratosis, and the appearance of verrucal keratosis or squamous cell carcinoma. Special attention must be paid to the development of new primary melanomas or changes on nevi during BRAF inhibitor therapy. The most common cutaneous side effects of immunotherapy are rash, pruritus, and vitiligo. It remains controversial the possible role of these toxicities as markers of response to therapy.

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Authors and Affiliations

  1. Dermatology Department, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Crta/Canyet s/n., Badalona, 08016, Barcelona, Spain

    A. Boada

  2. Melanoma Unit, Dermatology Department, Hospital Clinic, Institut d’investigacions biomèdiques August Pi i Sunyer (IDIBAPS), CIBERER, Universitat de Barcelona, Barcelona, Spain

    C. Carrera, S. Puig & J. Malvehy

  3. Dermatology Department, Hospital del Mar, Parc de Salut Mar, Fundació Institut Mar d’Investigacions Mèdiques, Barcelona, Spain

    S. Segura

  4. Sydney Melanoma Diagnostic Centre, Royal Prince Alfred Hospital, Sidney, Australia

    H. Collgros

  5. Dermatology Department, Pius Hospital Valls, Institut d’Investigació Sanitària Pere Virgili Valls, Tarragona, Spain

    P. Pasquali

  6. Dermatology Department, Hospital Universitari Vall d’Hebron, VHIR, Barcelona, Spain

    D. Bodet

Authors
  1. A. Boada
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  2. C. Carrera
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  3. S. Segura
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  4. H. Collgros
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  5. P. Pasquali
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  6. D. Bodet
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  7. S. Puig
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  8. J. Malvehy
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Corresponding author

Correspondence to A. Boada.

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Disclosure of potential conflicts of interest

Dr. Aram Boada has received speaker honorarium from Roche, Novartis, and BMS. Dr. Susana Puig has been consultant of Amgen, ISDIN, La Roche Posay, Leo Pharma, Almirall, Piere Fabre, BMS, and has received research grants from Leo Pharma, Almirall, and Novartis. Dr. Josep Malvehy has been consultant of Amgen, Novartis, BMS, Glaxo, Piere Fabre, Merk, MSD, Sanofi, Sunpharma, Incyte, Almirall, Leo Pharma, ISDIN, and has received research grants from Amgen, Novartis, Roche, BMS, Glaxo, Pierre Fabre, Merk, MSD, Sanofi, Sunpharma, Incyte, Almirall, and Leo Pharma. The remaining authors have no conflict of interest to declare.

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Boada, A., Carrera, C., Segura, S. et al. Cutaneous toxicities of new treatments for melanoma. Clin Transl Oncol 20, 1373–1384 (2018). https://doi.org/10.1007/s12094-018-1891-7

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  • DOI: https://doi.org/10.1007/s12094-018-1891-7

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